Search Results - "Sahu, Alexandria K."
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SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target
Published in Molecular cell (16-07-2015)“…Protein acylation links energetic substrate flux with cellular adaptive responses. SIRT5 is a NAD+-dependent lysine deacylase and removes both succinyl and…”
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SIRT5 Regulates the Mitochondrial Lysine Succinylome and Metabolic Networks
Published in Cell metabolism (03-12-2013)“…Reversible posttranslational modifications are emerging as critical regulators of mitochondrial proteins and metabolism. Here, we use a label-free quantitative…”
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Protein acetylation dynamics in response to carbon overflow in Escherichia coli
Published in Molecular microbiology (01-12-2015)“…Summary In Escherichia coli, acetylation of proteins at lysines depends largely on a non‐enzymatic acetyl phosphate‐dependent mechanism. To assess the…”
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4
MS1 Peptide Ion Intensity Chromatograms in MS2 (SWATH) Data Independent Acquisitions. Improving Post Acquisition Analysis of Proteomic Experiments[S]
Published in Molecular & cellular proteomics (01-09-2015)“…Quantitative analysis of discovery-based proteomic workflows now relies on high-throughput large-scale methods for identification and quantitation of proteins…”
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Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows
Published in Analytical chemistry (Washington) (20-10-2015)“…Recent advances in commercial mass spectrometers with higher resolving power and faster scanning capabilities have expanded their functionality beyond…”
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Phosphoprotein Secretome of Tumor Cells as a Source of Candidates for Breast Cancer Biomarkers in Plasma
Published in Molecular & cellular proteomics (01-04-2014)“…Breast cancer is a heterogeneous disease whose molecular diversity is not well reflected in clinical and pathological markers used for prognosis and treatment…”
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The E. coli sirtuin CobB shows no preference for enzymatic and nonenzymatic lysine acetylation substrate sites
Published in MicrobiologyOpen (Weinheim) (01-02-2015)“…Nε‐lysine acetylation is an abundant posttranslational modification of thousands of proteins involved in diverse cellular processes. In the model bacterium…”
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A framework for installable external tools in Skyline
Published in Bioinformatics (Oxford, England) (01-09-2014)“…Skyline is a Windows client application for targeted proteomics method creation and quantitative data analysis. The Skyline document model contains extensive…”
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Iron promotes protein insolubility and aging in C. elegans
Published in Aging (Albany, NY.) (01-11-2014)“…Many late-onset proteotoxic diseases are accompanied by a disruption in homeostasis of metals (metallostasis) including iron, copper and zinc. Although aging…”
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Variation and quantification among a target set of phosphopeptides in human plasma by multiple reaction monitoring and SWATH-MS2 data-independent acquisition
Published in Electrophoresis (01-12-2014)“…Human plasma contains proteins that reflect overall health and represents a rich source of proteins for identifying and understanding disease pathophysiology…”
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Protein acetylation dynamics in response to carbon overflow in E scherichia coli
Published in Molecular microbiology (01-12-2015)“…Summary In E scherichia coli , acetylation of proteins at lysines depends largely on a non‐enzymatic acetyl phosphate‐dependent mechanism. To assess the…”
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