Search Results - "Sahra, I. Ben"

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level by Sahra, I Ben, Laurent, K, Loubat, A, Giorgetti-Peraldi, S, Colosetti, P, Auberger, P, Tanti, J F, Le Marchand-Brustel, Y, Bost, F

“…Metformin is a widely used antidiabetic agent, which regulates glucose homeostasis through inhibition of liver glucose production and an increase in muscle…”
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Oncogenic PI3K and K-Ras stimulate de novo lipid synthesis through mTORC1 and SREBP by Ricoult, S J H, Yecies, J L, Ben-Sahra, I, Manning, B D

“…An enhanced capacity for de novo lipid synthesis is a metabolic feature of most cancer cells that distinguishes them from their cells of origin. However, the…”
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Sestrin2 integrates Akt and mTOR signaling to protect cells against energetic stress-induced death by Ben-Sahra, I, Dirat, B, Laurent, K, Puissant, A, Auberger, P, Budanov, A, Tanti, J-F, Bost, F

“…The phosphoinositide-3 kinase/Akt (PI3K/Akt) pathway has a central role in cancer cell metabolism and proliferation. More importantly, it is one of the…”
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The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment by Contenti, J., Guo, Y., Mazzu, A., Irondelle, M., Rouleau, M., Lago, C., Leva, G., Tiberi, L., Ben-Sahra, I., Bost, F., Mazure, N. M.

“…Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four groups defined by molecular characteristics, Group 3, the least well…”
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Low-dose radiation exposure induces a HIF-1-mediated adaptive and protective metabolic response by Lall, R, Ganapathy, S, Yang, M, Xiao, S, Xu, T, Su, H, Shadfan, M, Asara, J M, Ha, C S, Ben-Sahra, I, Manning, B D, Little, J B, Yuan, Z-M

“…Because of insufficient understanding of the molecular effects of low levels of radiation exposure, there is a great uncertainty regarding its health risks. We…”
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HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma by Contenti, J., Guo, Y., Larcher, M., Mirabal-Ortega, L., Rouleau, M., Irondelle, M., Tiroille, V., Mazzu, A., Duranton-Tanneur, V., Pedeutour, F., Ben-Sahra, I., Lago, C., Leva, G., Tiberi, L., Robert, G., Pouponnot, C., Bost, F., Mazure, N. M.

“…Medulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most metastatic. Its…”
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Targeting Cancer Cell Metabolism: The Combination of Metformin and 2-Deoxyglucose Induces p53-Dependent Apoptosis in Prostate Cancer Cells by BEN SAHRA, Issam, LAURENT, Kathiane, DECKERT, Marcel, AUBERGER, Patrick, TANTI, Jean-François, BOST, Frédéric, GIULIANO, Sandy, LARBRET, Frédéric, PONZIO, Gilles, GOUNON, Pierre, LE MARCHAND-BRUSTEL, Yannick, GIORGETTI-PERALDI, Sophie, CORMONT, Mireille, BERTOLOTTO, Corine

“…Targeting cancer cell metabolism is a new promising strategy to fight cancer. Metformin, a widely used antidiabetic agent, exerts antitumoral and…”
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The mitochondrial NADH shuttle system is a targetable vulnerability for Group 3 medulloblastoma in a hypoxic microenvironment by Contenti, J., Guo, Y, Mazzu, A, Irondelle, M, Rouleau, M, Lago, C, Leva, G, Tiberi, L, Ben-Sahra, I., Bost, Frédéric, Mazure, N M

“…Medulloblastoma is a cancerous brain tumor that affects mostly children. Among the four groups defined by molecular characteristics, Group 3, the least well…”
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O49 L’hypoxie inhibe la voie de signalisation de l’insuline dans les adipocytes by Regazzetti, C, Peraldi, P, Ben-Sahra, I, Cormont, M, Bost, F, Le Marchand-Brustel, Y, Tanti, J.F, Giorgetti-Peraldi, S

“…Introduction L’obésité se caractérise par une croissance excessive du tissu adipeux qui pourrait être à l’origine de la formation de zones hypoxiques. Nous…”
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OS6.1 Targeting Purine Metabolism to Overcome Therapeutic Resistance in Glioblastoma by Ahmed, A U, Shireman, J, Atashi, F, Saathoff, M, Ali, E, Lee, G, Park, C, Savchuk, S, Rayyan, J, James, C, Ben-Sahra, I

“…Abstract BACKGROUND A distinguishing characteristic of all cancers is uncontrolled cell division, and they require additional nucleotide bases such as purines,…”
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The energy disruptor metformin targets mitochondrial integrity via modification of calcium flux in cancer cells by Loubiere, Camille, Clavel, Stephan, Gilleron, Jerome, Harisseh, Rania, Fauconnier, Jeremy, Ben-Sahra, Issam, Kaminski, Lisa, Laurent, Kathiane, Herkenne, Stephanie, Lacas-Gervais, Sandra, Ambrosetti, Damien, Alcor, Damien, Rocchi, Stephane, Cormont, Mireille, Michiels, Jean-François, Mari, Bernard, Mazure, Nathalie M., Scorrano, Luca, Lacampagne, Alain, Gharib, Abdallah, Tanti, Jean-François, Bost, Frederic

“…Mitochondrial integrity is critical for the regulation of cellular energy and apoptosis. Metformin is an energy disruptor targeting complex I of the…”
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O45 La metformine exerce un effet anti-tumoral et entraîne un arrêt du cycle cellulaire by Ben Sahra, I, Laurent, K, Loubat, A, Peraldi, S.G, Colosetti, P, Auberger, P, Tanti, J.F, Le Marchand-Brustel, Y, Bost, F

“…Introduction La metformine est un médicament couramment prescrit contre le diabète de type II, qui inhibe la production hépatique de glucose et augmente la…”
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HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma by Contenti, J., Guo, Y., Larcher, M., Mirabal-Ortega, L., Rouleau, M., Irondelle, M., Tiroille, V., Mazzu, A., Duranton-Tanneur, V., Pedeutour, F., Ben-Sahra, I., Lago, C., Leva, G., Tiberi, L., Robert, G., Pouponnot, C., Bost, F., Mazure, Nathalie M

“…Abstract Medulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most…”
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LB06 - Eif5a hypusination shapes metabolic platicity in prostate cancer by Kahi, M., Mazzu, A., Tiroille, V., Vincent, A., Irondelle, M., Lacas-Gervais, S., Camoin, L., Auderbert, S., Diaz, J-J., Chen, Y., Ben-Sahra, I., Peraldi, P., Mazure, N., Bost, F.

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Eif5a hypusination shapes metabolic platicity in prostate cancer by Kahi, M., Mazzu, A., Tiroille, V., Vincent, A., Irondelle, M., Lacas-Gervais, S., Camoin, L., Auderbert, S., Diaz, J-J., Chen, Y., Ben-Sahra, I., Peraldi, P., Mazure, N., Bost, F.

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Un nouveau mécanisme de régulation de PTEN par la PI3-kinase by Ben Sahra, I.

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The anti-diabetic drug metformin exerts an anti-tumoral effect in vitro and in vivo through a decrease in cyclin D1 level by Sahra, I. Ben, Laurent, K, Loubat, A, Giorgetti-Peraldi, S, Colosetti, P, Auberger, P, Tanti, J.F, Marchand-Brustel, Y. Le, Bost, F

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The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin Dl level by BEN SAHRA, I, LAURENT, K, LOUBAT, A, GIORGETTI-PERALDI, S, COLOSETTI, P, AUBERGER, P, TANTI, J. F, LE MARCHAND-BRUSTEL, Y, BOST, F

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Obésité et cancers du côlon et de la prostate: implication des adipokines by Ben Sahra, I., Le Marchand Brustel, Y., Tanti, J. -F., Bost, F.

“…Résumé L’obésité est associée à de nombreuses pathologies comme le diabète et les maladies cardiovasculaires. Plus récemment, il a été montré que l’incidence…”
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Obésité et cancers du côlon et de la prostate : implication des adipokines : Obésité et cancer by BEN SAHRA, I, LE MARCHAND BRUSTEL, Y, TANTI, J.-F, BOST, F

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