Search Results - "Sahoo, Bikash R"

Amyloid Oligomers: A Joint Experimental/Computational Perspective on Alzheimer’s Disease, Parkinson’s Disease, Type II Diabetes, and Amyotrophic Lateral Sclerosis by Nguyen, Phuong H, Ramamoorthy, Ayyalusamy, Sahoo, Bikash R, Zheng, Jie, Faller, Peter, Straub, John E, Dominguez, Laura, Shea, Joan-Emma, Dokholyan, Nikolay V, De Simone, Alfonso, Ma, Buyong, Nussinov, Ruth, Najafi, Saeed, Ngo, Son Tung, Loquet, Antoine, Chiricotto, Mara, Ganguly, Pritam, McCarty, James, Li, Mai Suan, Hall, Carol, Wang, Yiming, Miller, Yifat, Melchionna, Simone, Habenstein, Birgit, Timr, Stepan, Chen, Jiaxing, Hnath, Brianna, Strodel, Birgit, Kayed, Rakez, Lesné, Sylvain, Wei, Guanghong, Sterpone, Fabio, Doig, Andrew J, Derreumaux, Philippe

“…Protein misfolding and aggregation is observed in many amyloidogenic diseases affecting either the central nervous system or a variety of peripheral tissues…”
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Current Status of Zika Virus Vaccines: Successes and Challenges by Pattnaik, Aryamav, Sahoo, Bikash R, Pattnaik, Asit K

“…The recently emerged Zika virus (ZIKV) spread to the Americas, causing a spectrum of congenital diseases including microcephaly in newborn and Guillain-Barré…”
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Lipid-Chaperone Hypothesis: A Common Molecular Mechanism of Membrane Disruption by Intrinsically Disordered Proteins by Sciacca, Michele F, Lolicato, Fabio, Tempra, Carmelo, Scollo, Federica, Sahoo, Bikash R, Watson, Matthew D, García-Viñuales, Sara, Milardi, Danilo, Raudino, Antonio, Lee, Jennifer C, Ramamoorthy, Ayyalusamy, La Rosa, Carmelo

“…An increasing number of human diseases has been shown to be linked to aggregation and amyloid formation by intrinsically disordered proteins (IDPs). Amylin,…”
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High-Speed Atomic Force Microscopy Reveals the Structural Dynamics of the Amyloid-β and Amylin Aggregation Pathways by Watanabe-Nakayama, Takahiro, Sahoo, Bikash R, Ramamoorthy, Ayyalusamy, Ono, Kenjiro

“…Individual Alzheimer's disease (AD) patients have been shown to have structurally distinct amyloid-β (Aβ) aggregates, including fibrils, in their brain. These…”
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Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs by Sahoo, Bikash R, Genjo, Takuya, Bekier, Michael, Cox, Sarah J, Stoddard, Andrea K, Ivanova, Magdalena, Yasuhara, Kazuma, Fierke, Carol A, Wang, Yanzhuang, Ramamoorthy, Ayyalusamy

“…Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (∼10 nm) and macro-nanodiscs (>15 nm) are used to study Aβ1-40 aggregation. We demonstrate that…”
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Self-Assembly of Polymer-Encased Lipid Nanodiscs and Membrane Protein Reconstitution by Sahoo, Bikash R, Genjo, Takuya, Moharana, Kanhu C, Ramamoorthy, Ayyalusamy

“…The absence of detergent and curvature makes nanodiscs excellent membrane mimetics. The lack of structural and mechanistic model of polymer-encapsulated lipid…”
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Mechanistic Target of Rapamycin Signaling Activation Antagonizes Autophagy To Facilitate Zika Virus Replication by Sahoo, Bikash R, Pattnaik, Aryamav, Annamalai, Arun S, Franco, Rodrigo, Pattnaik, Asit K

“…Zika virus (ZIKV), a mosquito-transmitted flavivirus, is linked to microcephaly and other neurological defects in neonates and Guillain-Barré syndrome in…”
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Investigation of the effects of two major secretory granules components, insulin and zinc, on human-IAPP amyloid aggregation and membrane damage by Khemtemourian, Lucie, Antoniciello, Federico, Sahoo, Bikash R., Decossas, Marion, Lecomte, Sophie, Ramamoorthy, Ayyalusamy

“…•Importance of residue-18 in hIAPP self-assembly in the presence of insulin.•Insulin slightly decreases the rate of hIAPP-membrane damage.•Insulin slightly…”
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Redox Regulation and Metabolic Dependency of Zika Virus Replication: Inhibition by Nrf2-Antioxidant Response and NAD(H) Antimetabolites by Sahoo, Bikash R, Crook, Alexandra A, Pattnaik, Aryamav, Torres-Gerena, Alondra D, Khalimonchuk, Oleh, Powers, Robert, Franco, Rodrigo, Pattnaik, Asit K

“…Viral infections alter host cell metabolism and homeostasis; however, the mechanisms that regulate these processes have only begun to be elucidated. We report…”
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Zika Virus Encoding Nonglycosylated Envelope Protein Is Attenuated and Defective in Neuroinvasion by Annamalai, Arun S, Pattnaik, Aryamav, Sahoo, Bikash R, Muthukrishnan, Ezhumalai, Natarajan, Sathish Kumar, Steffen, David, Vu, Hiep L X, Delhon, Gustavo, Osorio, Fernando A, Petro, Thomas M, Xiang, Shi-Hua, Pattnaik, Asit K

“…Zika virus (ZIKV), a mosquito-transmitted flavivirus responsible for sporadic outbreaks of mild and febrile illness in Africa and Asia, reemerged in the last…”
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Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils by Huettemann, Philipp, Mahadevan, Pavithra, Lempart, Justine, Tse, Eric, Dehury, Budheswar, Edwards, Brian F P, Southworth, Daniel R, Sahoo, Bikash R, Jakob, Ursula

“…Aberrant aggregation of α-Synuclein is the pathological hallmark of a set of neurodegenerative diseases termed synucleinopathies. Recent advances in…”
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Protein Nanoparticles as Vaccine Platforms for Human and Zoonotic Viruses by Pandey, Kush K, Sahoo, Bikash R, Pattnaik, Asit K

“…Vaccines are one of the most effective medical interventions, playing a pivotal role in treating infectious diseases. Although traditional vaccines comprise…”
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Inhibition of Zika virus replication by G-quadruplex-binding ligands by Majee, Prativa, Pattnaik, Aryamav, Sahoo, Bikash R., Shankar, Uma, Pattnaik, Asit K., Kumar, Amit, Nayak, Debasis

“…Zika virus (ZIKV), a mosquito-transmitted Flavivirus, emerged in the last decade causing serious diseases and affecting human health globally. Currently, no…”
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Conformational Tuning of Amylin by Charged Styrene-Maleic-Acid Copolymers by Sahoo, Bikash R., Souders, Christopher L., Watanabe-Nakayama, Takahiro, Deng, Zhou, Linton, Hunter, Suladze, Saba, Ivanova, Magdalena I., Reif, Bernd, Ando, Toshio, Martyniuk, Christopher J., Ramamoorthy, Ayyalusamy

“…[Display omitted] •The generation of morphologically and pathologically distinct amylin species is reported.•Cationic SMAQA polymer drives the formation of…”
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A Ferritin Nanoparticle-Based Zika Virus Vaccine Candidate Induces Robust Humoral and Cellular Immune Responses and Protects Mice from Lethal Virus Challenge by Pattnaik, Aryamav, Sahoo, Bikash R, Struble, Lucas R, Borgstahl, Gloria E O, Zhou, You, Franco, Rodrigo, Barletta, Raul G, Osorio, Fernando A, Petro, Thomas M, Pattnaik, Asit K

“…The severe consequences of the Zika virus (ZIKV) infections resulting in congenital Zika syndrome in infants and the autoimmune Guillain-Barre syndrome in…”
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High-resolution probing of early events in amyloid-β aggregation related to Alzheimer's disease by Sahoo, Bikash R, Cox, Sarah J, Ramamoorthy, Ayyalusamy

“…In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial entity in driving disease progression as compared to insoluble…”
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Direct interaction between the transmembrane helices stabilize cytochrome P450 2B4 and cytochrome b5 redox complex by Sahoo, Bikash R., Ramamoorthy, Ayyalusamy

“…The catalytic activity of cytochrome P450 2B4 (CYP2B4) is moderated by its cognate redox partner cytochrome b5 (Cyt-b5). The endoplasmic reticulum (ER)…”
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An Attenuated Zika Virus Encoding Non-Glycosylated Envelope (E) and Non-Structural Protein 1 (NS1) Confers Complete Protection against Lethal Challenge in a Mouse Model by Annamalai, Arun S, Pattnaik, Aryamav, Sahoo, Bikash R, Guinn, Zack P, Bullard, Brianna L, Weaver, Eric A, Steffen, David, Natarajan, Sathish Kumar, Petro, Thomas M, Pattnaik, Asit K

“…Zika virus (ZIKV), a mosquito-transmitted flavivirus, emerged in the last decade causing serious human diseases, including congenital microcephaly in newborns…”
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A conformational analysis of mouse Nalp3 domain structures by molecular dynamics simulations, and binding site analysis by Sahoo, Bikash R, Maharana, Jitendra, Bhoi, Gopal K, Lenka, Santosh K, Patra, Mahesh C, Dikhit, Manas R, Dubey, Praveen K, Pradhan, Sukanta K, Behera, Bijay K

“…Scrutinizing various nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) genes in higher eukaryotes is very important for understanding the…”
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SERF, a family of tiny highly conserved, highly charged proteins with enigmatic functions by Sahoo, Bikash R, Bardwell, James C A

“…Amyloid formation is a misfolding process that has been linked to age-related diseases, including Alzheimer's and Huntington's. Understanding how cellular…”
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