Search Results - "Sahm, Katharina"

L-RNA aptamer-based CXCL12 inhibition combined with radiotherapy in newly-diagnosed glioblastoma: dose escalation of the phase I/II GLORIA trial by Giordano, Frank A., Layer, Julian P., Leonardelli, Sonia, Friker, Lea L., Turiello, Roberta, Corvino, Dillon, Zeyen, Thomas, Schaub, Christina, Müller, Wolf, Sperk, Elena, Schmeel, Leonard Christopher, Sahm, Katharina, Oster, Christoph, Kebir, Sied, Hambsch, Peter, Pietsch, Torsten, Bisdas, Sotirios, Platten, Michael, Glas, Martin, Seidel, Clemens, Herrlinger, Ulrich, Hölzel, Michael

“…The chemokine CXCL12 promotes glioblastoma (GBM) recurrence after radiotherapy (RT) by facilitating vasculogenesis. Here we report outcomes of the…”
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Targeting the aryl hydrocarbon receptor (AhR) with BAY 2416964: a selective small molecule inhibitor for cancer immunotherapy by Kober, Christina, Roewe, Julian, Schmees, Norbert, Roese, Lars, Roehn, Ulrike, Bader, Benjamin, Stoeckigt, Detlef, Prinz, Florian, Gorjánácz, Mátyás, Roider, Helge Gottfried, Olesch, Catherine, Leder, Gabriele, Irlbacher, Horst, Lesche, Ralf, Lefranc, Julien, Oezcan-Wahlbrink, Mine, Batra, Ankita Sati, Elmadany, Nirmeen, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Cichon, Frederik, Baumann, Daniel, Sadik, Ahmed, Opitz, Christiane A, Weinmann, Hilmar, Hartung, Ingo V, Kreft, Bertolt, Offringa, Rienk, Platten, Michael, Gutcher, Ilona

“…BackgroundThe metabolism of tryptophan to kynurenines (KYN) by indoleamine-2,3-dioxygenase or tryptophan-2,3-dioxygenase is a key pathway of constitutive and…”
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807 A vaccine targeting the recurrent driver mutation H3K27M induces mutation specific T- and B- cell responses in patients with diffuse midline Gliomas by Boschert, Tamara, Lerner, Taga, Kromer, Kristina, Lindner, Katharina, Poschke, Isabel, Mildenberger, Iris, Haltenhof, Gordon, Sahm, Katharina, Lindner, John, Green, Edward, Platten, Michael

“…BackgroundA recurrent point mutation at position 27 in the histone-3 gene (H3K27M) defines a distinct subtype of highly aggressive diffuse midline gliomas…”
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861 Fractionated irradiation activates glioma immune microenvironment and boosts antigen-specific T cell response in experimental gliomas by Elmadany, Nirmeen, Michel, Julius, Sonner, Jana, Ovchinnikova, Svetlana, Sanghvi, Khwab, Bernhardt, Isabelle, Zhang, Xin-Wen, Jähne, Kristine, Sati, Ankita, Anders, Simon, Breckwoldt, Michael, Platten, Michael, Sahm, Katharina

“…BackgroundGlioblastoma (GBM) is the most aggressive primary brain tumor with a survival rate of 14–16 months. Several ongoing clinical trials employ vaccine,…”
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Activity-regulated cytoskeleton-associated protein/activity-regulated gene 3.1 (Arc/Arg3.1) enhances dendritic cell vaccination in experimental melanoma by Zhang, Xin-Wen, Huck, Katrin, Jähne, Kristine, Cichon, Frederik, Sonner, Jana K., Ufer, Friederike, Bauer, Simone, Woo, Marcel Seungsu, Green, Ed, Lu, Kevin, Kilian, Michael, Friese, Manuel A., Platten, Michael, Sahm, Katharina

“…Dendritic cell (DC) vaccination has proven to be an effective and safe adjuvant for cancer immunotherapies. As the presence of DCs within the tumor…”
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Autoimmune diseases and immunosuppressive therapy in relation to the risk of glioma by Anssar, Tareq M., Leitzmann, Michael F., Linker, Ralf A., Meier, Christoph, Becker, Claudia, Jick, Susan, Sahm, Katharina, Platten, Michael, Hau, Peter, Seliger, Corinna

“…Effectors from the immune system can modulate the course and possibly the early development of gliomas. We, therefore, hypothesized that autoimmune diseases…”
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Concurrent gliomas in patients with multiple sclerosis by Sahm, Katharina, Kessler, Tobias, Eisele, Philipp, Ratliff, Miriam, Sperk, Elena, König, Laila, Breckwoldt, Michael O., Seliger, Corinna, Mildenberger, Iris, Schrimpf, Daniel, Herold-Mende, Christel, Zeiner, Pia S., Tabatabai, Ghazaleh, Meuth, Sven G., Capper, David, Bendszus, Martin, von Deimling, Andreas, Wick, Wolfgang, Sahm, Felix, Platten, Michael

“…Background Concurrent malignant brain tumors in patients with multiple sclerosis (MS) constitute a rare but paradigmatic phenomenon for studying…”
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INTERCEPT H3: a multicenter phase I peptide vaccine trial for the treatment of H3-mutated diffuse midline gliomas by Grassl, Niklas, Sahm, Katharina, Süße, Heike, Poschke, Isabel, Bunse, Lukas, Bunse, Theresa, Boschert, Tamara, Mildenberger, Iris, Rupp, Anne-Kathleen, Ewinger, Max Philipp, Lanz, Lisa-Marie, Denk, Monika, Tabatabai, Ghazaleh, Ronellenfitsch, Michael W, Herrlinger, Ulrich, Glas, Martin, Krex, Dietmar, Vajkoczy, Peter, Wick, Antje, Harting, Inga, Sahm, Felix, von Deimling, Andreas, Bendszus, Martin, Wick, Wolfgang, Platten, Michael

“…Abstract Introduction Diffuse midline gliomas (DMG) are universally lethal central nervous system tumors that carry almost unanimously the clonal driver…”
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Immuntherapie gegen Gliome by Sahm, Katharina, Weiss, Tobias

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Immunotherapy against gliomas by Sahm, Katharina, Weiss, Tobias

“…Gliomas represent the most frequent malignant primary brain tumors in adults. Despite multimodal treatment concepts involving surgery, irradiation and…”
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Immuntherapie gegen Gliome by Sahm, Katharina, Weiss, Tobias

“…Zusammenfassung Hintergrund Gliome sind die häufigsten bösartigen primären Hirntumoren bei Erwachsenen. Trotz multimodaler Therapiekonzepte aus Chirurgie,…”
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A H3K27M-targeted vaccine in adults with diffuse midline glioma by Grassl, Niklas, Poschke, Isabel, Lindner, Katharina, Bunse, Lukas, Mildenberger, Iris, Boschert, Tamara, Jähne, Kristine, Green, Edward W., Hülsmeyer, Ingrid, Jünger, Simone, Kessler, Tobias, Suwala, Abigail K., Eisele, Philipp, Breckwoldt, Michael O., Vajkoczy, Peter, Grauer, Oliver M., Herrlinger, Ulrich, Tonn, Joerg-Christian, Denk, Monika, Sahm, Felix, Bendszus, Martin, von Deimling, Andreas, Winkler, Frank, Wick, Wolfgang, Platten, Michael, Sahm, Katharina

“…Substitution of lysine 27 to methionine in histone H3 (H3K27M) defines an aggressive subtype of diffuse glioma. Previous studies have shown that a…”
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Potential predictive biomarker for response to radiotherapy and CXCL12 inhibition in glioblastoma in the phase I/II GLORIA trial by Giordano, Frank Anton, Layer, Julian Philipp, Leonardelli, Sonia, Friker, Lea Lydia, Turiello, Roberta, Corvino, Dillon, Zeyen, Thomas, Schaub, Christina, Mueller, Wolf, Sperk, Elena, Schmeel, Leonard Christopher, Sahm, Katharina, Kebir, Sied, Hambsch, Peter, Pietsch, Torsten, Bisdas, Sotirios, Glas, Martin, Seidel, Clemens, Herrlinger, Ulrich, Hölzel, Michael

“…2048 Background: Standard of care (SOC) treatment achieves poor clinical outcomes in patients with glioblastoma (GBM), particularly in the absence of MGMT…”
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Cerebrospinal fluid cfDNA sequencing for classification of central nervous system glioma by Iser, Florian, Hinz, Felix, Hoffmann, Dirk C, Grassl, Niklas, Güngör, Cansu, Meyer, Jochen, Dörner, Laura, Hofmann, Lea, Kelbch, Vanessa, Göbel, Kirsten, Mahmutoglu, Mustafa Ahmed, Vollmuth, Phillipp, Patel, Areeba, Nguyen, Duy, Kaulen, Leon D, Mildenberger, Iris, Sahm, Katharina, Maaß, Kendra, Pajtler, Kristian W, Shankar, Ganesh M, Weiler, Markus, Wildemann, Brigitte, Winkler, Frank, von Deimling, Andreas, Platten, Michael, Wick, Wolfgang, Sahm, Felix, Kessler, Tobias

“…Primary central nervous system (CNS) gliomas can be classified by characteristic genetic alterations. In addition to solid tissue obtained via surgery or…”
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Radiotherapy and olaptesed pegol (NOX-A12) in partially resected or biopsy-only MGMT-unmethylated glioblastoma: Interim data from the German multicenter phase 1/2 GLORIA trial by Giordano, Frank Anton, Layer, Julian Philipp, Leonardelli, Sonia, Friker, Lea Lydia, Seidel, Clemens, Schaub, Christina, Turiello, Roberta, Sperk, Elena, Grau, Franziska, Paech, Daniel, Link, Barbara, Mueller, Wolf, Tabatabai, Ghazaleh, Sahm, Katharina, Kebir, Sied, Pietsch, Torsten, Glas, Martin, Bisdas, Sotiros, Herrlinger, Ulrich, Hölzel, Michael

“…2050 Background: Pre-clinical studies consistently demonstrate that inhibition of the CXCL12/CXCR4/CXCR7 axis abrogates recruitment of pro-vasculogenic bone…”
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CTNI-43. CXCL12 INHIBITION IN MGMT UNMETHYLATED GLIOBLASTOMA – RESULTS OF AN EARLY PROOF-OF-CONCEPT ASSESSMENT IN THE MULTICENTRIC PHASE I/II GLORIA TRIAL (NCT04121455) by Giordano, Frank, Layer, Julian, Leonardelli, Sonia, Friker, Lea, Seidel, Clemens, Zeyen, Thomas, Schaub, Christina, Sperk, Elena, Sahm, Katharina, Kebir, Sied, Hambsch, Peter, Pietsch, Torsten, Glas, Martin, Bisdas, Sotirios, Hölzel, Michael, Herrlinger, Ulrich

“…Abstract BACKGROUND Preclinical studies showed that CXCL12-mediated influx of highly angiogenic monocytes/macrophages is a key driver of tumor…”
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In vivo nanoparticle-based T cell imaging can predict therapy response towards adoptive T cell therapy in experimental glioma by Hunger, Jessica, Schregel, Katharina, Boztepe, Berin, Agardy, Dennis Alexander, Turco, Verena, Karimian-Jazi, Kianush, Weidenfeld, Ina, Streibel, Yannik, Fischer, Manuel, Sturm, Volker, Santarella-Mellwig, Rachel, Kilian, Michael, Jähne, Kristine, Sahm, Katharina, Wick, Wolfgang, Bunse, Lukas, Heiland, Sabine, Bunse, Theresa, Bendszus, Martin, Platten, Michael, Breckwoldt, Michael O.

“…Rationale: Intrinsic brain tumors, such as gliomas are largely resistant to immunotherapies including immune checkpoint blockade. Adoptive cell therapies (ACT)…”
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Abstract 1288: Blocking tumor-associated immune suppression with BAY-218, a novel, selective aryl hydrocarbon receptor (AhR) inhibitor by Gutcher, Ilona, Kober, Christina, Roese, Lars, Roewe, Julian, Schmees, Norbert, Prinz, Florian, Gorjanacz, Matyas, Roehn, Ulrike, Bader, Benjamin, Irlbacher, Horst, Stoeckigt, Detlef, Carretero, Rafael, Sahm, Katharina, Oezen, Iris, Weinmann, Hilmar, Hartung, Ingo V., Kreft, Bertolt, Platten, Michael

“…Abstract Tumor cells co-opt multiple pathways in order to evade attack by infiltrating immune cells. One such mechanism is the upregulation of…”
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H3K27M neoepitope vaccination in diffuse midline glioma induces B and T cell responses across diverse HLA loci of a recovered patient by Boschert, Tamara, Kromer, Kristina, Lerner, Taga, Lindner, Katharina, Haltenhof, Gordon, Tan, Chin Leng, Jähne, Kristine, Poschke, Isabel, Bunse, Lukas, Eisele, Philipp, Grassl, Niklas, Mildenberger, Iris, Sahm, Katharina, Platten, Michael, Lindner, John M, Green, Edward W

“…H3K27M, a driver mutation with T and B cell neoepitope characteristics, defines an aggressive subtype of diffuse glioma with poor survival. We functionally…”
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Molecular profiling-based decision for targeted therapies in IDH wild-type glioblastoma by Kessler, Tobias, Berberich, Anne, Casalini, Belen, Drüschler, Katharina, Ostermann, Hannah, Dormann, Andrea, Walter, Sandy, Hai, Ling, Schlesner, Matthias, Herold-Mende, Christel, Jungk, Christine, Unterberg, Andreas, Bendszus, Martin, Sahm, Katharina, von Deimling, Andreas, Winkler, Frank, Platten, Michael, Wick, Wolfgang, Sahm, Felix, Wick, Antje

“…Abstract Background Molecular profiling allows tumor classification as well as assessment of diagnostic, prognostic, and treatment-related molecular changes…”
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