Search Results - "Sahm, Felix"

Molecular alterations in meningioma: prognostic and therapeutic perspectives by Birzu, Cristina, Peyre, Matthieu, Sahm, Felix

“…PURPOSE OF REVIEWTo discuss recent advances in the meningioma biology and their clinical implications. RECENT FINDINGSMeningioma is the most common primary…”
Get full text

DNA methylation profiling as a model for discovery and precision diagnostics in neuro-oncology by Pratt, Drew, Sahm, Felix, Aldape, Kenneth

“…Abstract Recent years have witnessed a shift to more objective and biologically-driven methods for central nervous system (CNS) tumor classification. The 2016…”
Get full text

EANO guideline on the diagnosis and management of meningiomas by Goldbrunner, Roland, Stavrinou, Pantelis, Jenkinson, Michael D, Sahm, Felix, Mawrin, Christian, Weber, Damien C, Preusser, Matthias, Minniti, Giuseppe, Lund-Johansen, Morten, Lefranc, Florence, Houdart, Emanuel, Sallabanda, Kita, Le Rhun, Emilie, Nieuwenhuizen, David, Tabatabai, Ghazaleh, Soffietti, Riccardo, Weller, Michael

“…Abstract Meningiomas are the most common intracranial tumors. Yet, only few controlled clinical trials have been conducted to guide clinical decision making,…”
Get full text

A vaccine targeting mutant IDH1 in newly diagnosed glioma by Platten, Michael, Bunse, Lukas, Wick, Antje, Bunse, Theresa, Le Cornet, Lucian, Harting, Inga, Sahm, Felix, Sanghvi, Khwab, Tan, Chin Leng, Poschke, Isabel, Green, Edward, Justesen, Sune, Behrens, Geoffrey A., Breckwoldt, Michael O., Freitag, Angelika, Rother, Lisa-Marie, Schmitt, Anita, Schnell, Oliver, Hense, Jörg, Misch, Martin, Krex, Dietmar, Stevanovic, Stefan, Tabatabai, Ghazaleh, Steinbach, Joachim P., Bendszus, Martin, von Deimling, Andreas, Schmitt, Michael, Wick, Wolfgang

“…Mutated isocitrate dehydrogenase 1 ( IDH1 ) defines a molecularly distinct subtype of diffuse glioma 1 – 3 . The most common IDH1 mutation in gliomas affects…”
Get full text

cIMPACT‐NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT‐Utrecht meeting on future CNS tumor classification and grading by Louis, David N., Wesseling, Pieter, Aldape, Kenneth, Brat, Daniel J., Capper, David, Cree, Ian A., Eberhart, Charles, Figarella‐Branger, Dominique, Fouladi, Maryam, Fuller, Gregory N., Giannini, Caterina, Haberler, Christine, Hawkins, Cynthia, Komori, Takashi, Kros, Johan M., Ng, HK, Orr, Brent A., Park, Sung‐Hye, Paulus, Werner, Perry, Arie, Pietsch, Torsten, Reifenberger, Guido, Rosenblum, Marc, Rous, Brian, Sahm, Felix, Sarkar, Chitra, Solomon, David A., Tabori, Uri, Bent, Martin J., Deimling, Andreas, Weller, Michael, White, Valerie A., Ellison, David W.

“…cIMPACT‐NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations…”
Get full text

Practical implementation of DNA methylation and copy-number-based CNS tumor diagnostics: the Heidelberg experience by Capper, David, Stichel, Damian, Sahm, Felix, Jones, David T. W., Schrimpf, Daniel, Sill, Martin, Schmid, Simone, Hovestadt, Volker, Reuss, David E., Koelsche, Christian, Reinhardt, Annekathrin, Wefers, Annika K., Huang, Kristin, Sievers, Philipp, Ebrahimi, Azadeh, Schöler, Anne, Teichmann, Daniel, Koch, Arend, Hänggi, Daniel, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Witt, Olaf, Milde, Till, Korshunov, Andrey, Pfister, Stefan M., von Deimling, Andreas

“…Recently, we described a machine learning approach for classification of central nervous system tumors based on the analysis of genome-wide DNA methylation…”
Get full text

Tumor cell plasticity, heterogeneity, and resistance in crucial microenvironmental niches in glioma by Jung, Erik, Osswald, Matthias, Ratliff, Miriam, Dogan, Helin, Xie, Ruifan, Weil, Sophie, Hoffmann, Dirk C., Kurz, Felix T., Kessler, Tobias, Heiland, Sabine, von Deimling, Andreas, Sahm, Felix, Wick, Wolfgang, Winkler, Frank

“…Both the perivascular niche (PVN) and the integration into multicellular networks by tumor microtubes (TMs) have been associated with progression and…”
Get full text

TERT Promoter Mutations and Risk of Recurrence in Meningioma by Sahm, Felix, Schrimpf, Daniel, Olar, Adriana, Koelsche, Christian, Reuss, David, Bissel, Juliane, Kratz, Annekathrin, Capper, David, Schefzyk, Sebastian, Hielscher, Thomas, Wang, Qianghu, Sulman, Erik P, Adeberg, Sebastian, Koch, Arend, Okuducu, Ali Fuat, Brehmer, Stefanie, Schittenhelm, Jens, Becker, Albert, Brokinkel, Benjamin, Schmidt, Melissa, Ull, Theresa, Gousias, Konstantinos, Kessler, Almuth Friederike, Lamszus, Katrin, Debus, Jürgen, Mawrin, Christian, Kim, Yoo-Jin, Simon, Matthias, Ketter, Ralf, Paulus, Werner, Aldape, Kenneth D, Herold-Mende, Christel, von Deimling, Andreas

“…The World Health Organization (WHO) classification and grading system attempts to predict the clinical course of meningiomas based on morphological parameters…”
Get full text

Primary central nervous system lymphoma and atypical glioblastoma: multiparametric differentiation by using diffusion-, perfusion-, and susceptibility-weighted MR imaging by Kickingereder, Philipp, Wiestler, Benedikt, Sahm, Felix, Heiland, Sabine, Roethke, Matthias, Schlemmer, Heinz-Peter, Wick, Wolfgang, Bendszus, Martin, Radbruch, Alexander

“…To compare multiparametric diagnostic performance with diffusion-weighted, dynamic susceptibility-weighted contrast material-enhanced perfusion-weighted, and…”
Get full text

Heterogeneity of response to immune checkpoint blockade in hypermutated experimental gliomas by Aslan, Katrin, Turco, Verena, Blobner, Jens, Sonner, Jana K., Liuzzi, Anna Rita, Núñez, Nicolás Gonzalo, De Feo, Donatella, Kickingereder, Philipp, Fischer, Manuel, Green, Ed, Sadik, Ahmed, Friedrich, Mirco, Sanghvi, Khwab, Kilian, Michael, Cichon, Frederik, Wolf, Lara, Jähne, Kristine, von Landenberg, Anna, Bunse, Lukas, Sahm, Felix, Schrimpf, Daniel, Meyer, Jochen, Alexander, Allen, Brugnara, Gianluca, Röth, Ralph, Pfleiderer, Kira, Niesler, Beate, von Deimling, Andreas, Opitz, Christiane, Breckwoldt, Michael O., Heiland, Sabine, Bendszus, Martin, Wick, Wolfgang, Becher, Burkhard, Platten, Michael

“…Intrinsic malignant brain tumors, such as glioblastomas are frequently resistant to immune checkpoint blockade (ICB) with few hypermutated glioblastomas…”
Get full text

IDH mutant diffuse and anaplastic astrocytomas have similar age at presentation and little difference in survival: a grading problem for WHO by Reuss, David E., Mamatjan, Yasin, Schrimpf, Daniel, Capper, David, Hovestadt, Volker, Kratz, Annekathrin, Sahm, Felix, Koelsche, Christian, Korshunov, Andrey, Olar, Adriana, Hartmann, Christian, Reijneveld, Jaap C., Wesseling, Pieter, Unterberg, Andreas, Platten, Michael, Wick, Wolfgang, Herold-Mende, Christel, Aldape, Kenneth, von Deimling, Andreas

“…The WHO 2007 classification of tumors of the CNS distinguishes between diffuse astrocytoma WHO grade II (A II WHO2007 ) and anaplastic astrocytoma WHO grade…”
Get full text

Prognostic impact of genetic alterations and methylation classes in meningioma by Berghoff, Anna S., Hielscher, Thomas, Ricken, Gerda, Furtner, Julia, Schrimpf, Daniel, Widhalm, Georg, Rajky, Ursula, Marosi, Christine, Hainfellner, Johannes A., Deimling, Andreas, Sahm, Felix, Preusser, Matthias

“…Meningiomas are classified based on histological features, but genetic and epigenetic features are emerging as relevant biomarkers for outcome prediction and…”
Get full text

Tweety-Homolog 1 Drives Brain Colonization of Gliomas by Jung, Erik, Osswald, Matthias, Blaes, Jonas, Wiestler, Benedikt, Sahm, Felix, Schmenger, Torsten, Solecki, Gergely, Deumelandt, Katrin, Kurz, Felix T, Xie, Ruifan, Weil, Sophie, Heil, Oliver, Thomé, Carina, Gömmel, Miriam, Syed, Mustafa, Häring, Peter, Huber, Peter E, Heiland, Sabine, Platten, Michael, von Deimling, Andreas, Wick, Wolfgang, Winkler, Frank

“…Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas, including glioblastomas. We recently discovered ultralong (>10 to…”
Get full text

A subset of pediatric-type thalamic gliomas share a distinct DNA methylation profile, H3K27me3 loss and frequent alteration of EGFR by Sievers, Philipp, Sill, Martin, Schrimpf, Daniel, Stichel, Damian, Reuss, David E, Sturm, Dominik, Hench, Jürgen, Frank, Stephan, Krskova, Lenka, Vicha, Ales, Zapotocky, Michal, Bison, Brigitte, Castel, David, Grill, Jacques, Debily, Marie-Anne, Harter, Patrick N, Snuderl, Matija, Kramm, Christof M, Reifenberger, Guido, Korshunov, Andrey, Jabado, Nada, Wesseling, Pieter, Wick, Wolfgang, Solomon, David A, Perry, Arie, Jacques, Thomas S, Jones, Chris, Witt, Olaf, Pfister, Stefan M, von Deimling, Andreas, Jones, David T W, Sahm, Felix

“…Abstract Background Malignant astrocytic gliomas in children show a remarkable biological and clinical diversity. Small in-frame insertions or missense…”
Get full text

Next-generation sequencing in routine brain tumor diagnostics enables an integrated diagnosis and identifies actionable targets by Sahm, Felix, Schrimpf, Daniel, Jones, David T. W., Meyer, Jochen, Kratz, Annekathrin, Reuss, David, Capper, David, Koelsche, Christian, Korshunov, Andrey, Wiestler, Benedikt, Buchhalter, Ivo, Milde, Till, Selt, Florian, Sturm, Dominik, Kool, Marcel, Hummel, Manuela, Bewerunge-Hudler, Melanie, Mawrin, Christian, Schüller, Ulrich, Jungk, Christine, Wick, Antje, Witt, Olaf, Platten, Michael, Herold-Mende, Christel, Unterberg, Andreas, Pfister, Stefan M., Wick, Wolfgang, von Deimling, Andreas

“…With the number of prognostic and predictive genetic markers in neuro-oncology steadily growing, the need for comprehensive molecular analysis of…”
Get full text

Tumor Infiltration in Enhancing and Non-Enhancing Parts of Glioblastoma: A Correlation with Histopathology by Eidel, Oliver, Burth, Sina, Neumann, Jan-Oliver, Kieslich, Pascal J, Sahm, Felix, Jungk, Christine, Kickingereder, Philipp, Bickelhaupt, Sebastian, Mundiyanapurath, Sibu, Bäumer, Philipp, Wick, Wolfgang, Schlemmer, Heinz-Peter, Kiening, Karl, Unterberg, Andreas, Bendszus, Martin, Radbruch, Alexander

“…To correlate histopathologic findings from biopsy specimens with their corresponding location within enhancing areas, non-enhancing areas and necrotic areas on…”
Get full text

Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma by Sahm, Felix, Reuss, David, Koelsche, Christian, Capper, David, Schittenhelm, Jens, Heim, Stephanie, Jones, David T. W., Pfister, Stefan M., Herold-Mende, Christel, Wick, Wolfgang, Mueller, Wolf, Hartmann, Christian, Paulus, Werner, von Deimling, Andreas

“…Astrocytoma and oligodendroglioma are histologically and genetically well-defined entities. The majority of astrocytomas harbor concurrent TP53 and ATRX…”
Get full text

BRAFV600E mutant protein is expressed in cells of variable maturation in Langerhans cell histiocytosis by Sahm, Felix, Capper, David, Preusser, Matthias, Meyer, Jochen, Stenzinger, Albrecht, Lasitschka, Felix, Berghoff, Anna-Sophie, Habel, Antje, Schneider, Marion, Kulozik, Andreas, Anagnostopoulos, Ioannis, Müllauer, Leonhard, Mechtersheimer, Gunhild, von Deimling, Andreas

“…Langerhans cell histiocytosis (LCH) is a clinically and histologically heterogeneous disorder. Its classification as either reactive inflammatory or neoplastic…”
Get full text

Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo by Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, von Deimling, Andreas

“…Mutations in codon 132 of isocitrate dehydrogenase ( IDH ) 1 are frequent in diffuse glioma, acute myeloid leukemia, chondrosarcoma and intrahepatic…”
Get full text

Constitutive IDO expression in human cancer is sustained by an autocrine signaling loop involving IL-6, STAT3 and the AHR by Litzenburger, Ulrike M, Opitz, Christiane A, Sahm, Felix, Rauschenbach, Katharina J, Trump, Saskia, Winter, Marcus, Ott, Martina, Ochs, Katharina, Lutz, Christian, Liu, Xiangdong, Anastasov, Natasa, Lehmann, Irina, Höfer, Thomas, von Deimling, Andreas, Wick, Wolfgang, Platten, Michael

“…Indoleamine-2,3-dioxygenase (IDO) inhibitors have entered clinical trials based on their ability to restore anti-tumor immunity in preclinical studies…”
Get full text