Search Results - "Sahay, Gaurav"

Chemistry of Lipid Nanoparticles for RNA Delivery by Eygeris, Yulia, Gupta, Mohit, Kim, Jeonghwan, Sahay, Gaurav

“…Conspectus Lipid nanoparticles (LNPs) are a type of lipid vesicles that possess a homogeneous lipid core. These vesicles are widely used in small-molecule drug…”
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Deconvoluting Lipid Nanoparticle Structure for Messenger RNA Delivery by Eygeris, Yulia, Patel, Siddharth, Jozic, Antony, Sahay, Gaurav

“…Lipid nanoparticle (LNP) packaged mRNA vaccines have been deployed against infectious diseases such as COVID-19, yet their structural features remain unclear…”
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Nanomedicine hitchhikes on neutrophils to the inflamed lung by Kim, Jeonghwan, Sahay, Gaurav

“…Supramolecular arrangement of proteins provides nanoparticles with neutrophil tropism via complement opsonization during an acute inflammation, enabling…”
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Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA by Patel, Siddharth, Ashwanikumar, N., Robinson, Ema, Xia, Yan, Mihai, Cosmin, Griffith, Joseph P., Hou, Shangguo, Esposito, Adam A., Ketova, Tatiana, Welsher, Kevin, Joyal, John L., Almarsson, Örn, Sahay, Gaurav

“…Endosomal sequestration of lipid-based nanoparticles (LNPs) remains a formidable barrier to delivery. Herein, structure-activity analysis of cholesterol…”
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Naturally Derived Membrane Lipids Impact Nanoparticle-Based Messenger RNA Delivery by Kim, Jeonghwan, Jozic, Antony, Sahay, Gaurav

“…Introduction Lipid based nanoparticles (LNPs) are clinically successful vectors for hepatic delivery of nucleic acids. These systems are being developed for…”
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Lipid Nanoparticle-Delivered Chemically Modified mRNA Restores Chloride Secretion in Cystic Fibrosis by Robinson, Ema, MacDonald, Kelvin D., Slaughter, Kai, McKinney, Madison, Patel, Siddharth, Sun, Conroy, Sahay, Gaurav

“…The promise of gene therapy for the treatment of cystic fibrosis has yet to be fully clinically realized despite years of effort toward correcting the…”
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The effects of PEGylation on LNP based mRNA delivery to the eye by Ryals, Renee C, Patel, Siddharth, Acosta, Chris, McKinney, Madison, Pennesi, Mark E, Sahay, Gaurav

“…Gene therapy is now an effective approach to treat many forms of retinal degeneration. Delivery agents that are cell-specific, allow for multiple dosing…”
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Efficiency of siRNA delivery by lipid nanoparticles is limited by endocytic recycling by Sahay, Gaurav, Querbes, William, Alabi, Christopher, Eltoukhy, Ahmed, Sarkar, Sovan, Zurenko, Christopher, Karagiannis, Emmanouil, Love, Kevin, Chen, Delai, Zoncu, Roberto, Buganim, Yosef, Schroeder, Avi, Langer, Robert, Anderson, Daniel G

“…Detailed analyses of siRNA delivery by lipid nanoparticles reveal major pathways of siRNA internalization and endosomal escape. Despite efforts to understand…”
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Boosting Intracellular Delivery of Lipid Nanoparticle-Encapsulated mRNA by Patel, Siddharth, Ashwanikumar, N, Robinson, Emily, DuRoss, Allison, Sun, Conroy, Murphy-Benenato, Kerry E, Mihai, Cosmin, Almarsson, Örn, Sahay, Gaurav

“…Intracellular delivery of mRNA holds great potential for vaccine − and therapeutic discovery and development. Despite increasing recognition of the utility of…”
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Advances in intracellular delivery through supramolecular self-assembly of oligonucleotides and peptides by Kim, Jeonghwan, Narayana, Ashwanikumar, Patel, Siddharth, Sahay, Gaurav

“…Cells utilize natural supramolecular assemblies to maintain homeostasis and biological functions. Naturally inspired modular assembly of biomaterials are now…”
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Challenges in carrier-mediated intracellular delivery: moving beyond endosomal barriers by Stewart, Martin P., Lorenz, Anna, Dahlman, James, Sahay, Gaurav

“…The deployment of molecular to microscale carriers for intracellular delivery has tremendous potential for biology and medicine, especially for in vivo…”
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Rapid Discovery of Potent siRNA-Containing Lipid Nanoparticles Enabled by Controlled Microfluidic Formulation by Chen, Delai, Love, Kevin T, Chen, Yi, Eltoukhy, Ahmed A, Kastrup, Christian, Sahay, Gaurav, Jeon, Alvin, Dong, Yizhou, Whitehead, Kathryn A, Anderson, Daniel G

“…The discovery of potent new materials for in vivo delivery of nucleic acids depends upon successful formulation of the active molecules into a dosage form…”
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Lipid nanoparticles with PEG-variant surface modifications mediate genome editing in the mouse retina by Gautam, Milan, Jozic, Antony, Su, Grace Li-Na, Herrera-Barrera, Marco, Curtis, Allison, Arrizabalaga, Sebastian, Tschetter, Wayne, Ryals, Renee C., Sahay, Gaurav

“…Ocular delivery of lipid nanoparticle (LNPs) packaged mRNA can enable efficient gene delivery and editing. We generated LNP variants through the inclusion of…”
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Lipopeptide nanoparticles for potent and selective siRNA delivery in rodents and nonhuman primates by Dong, Yizhou, Love, Kevin T., Dorkin, J. Robert, Sirirungruang, Sasilada, Zhang, Yunlong, Chen, Delai, Bogorad, Roman L., Yin, Hao, Chen, Yi, Vegas, Arturo J., Alabi, Christopher A., Sahay, Gaurav, Olejnik, Karsten T., Wang, Weiheng, Schroeder, Avi, Lytton-Jean, Abigail K. R., Siegwart, Daniel J., Akinc, Akin, Barnes, Carmen, Barros, Scott A., Carioto, Mary, Fitzgerald, Kevin, Hettinger, Julia, Kumar, Varun, Novobrantseva, Tatiana I., Qin, June, Querbes, William, Koteliansky, Victor, Langer, Robert, Anderson, Daniel G.

“…siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as…”
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RNA-Based Therapeutics: Current Developments in Targeted Molecular Therapy of Triple-Negative Breast Cancer by Haque, Sakib, Cook, Kiri, Sahay, Gaurav, Sun, Conroy

“…Triple-negative breast cancer (TNBC) is a highly heterogeneous and aggressive cancer that has the highest mortality rate out of all breast cancer subtypes…”
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Small RNA combination therapy for lung cancer by Xue, Wen, Dahlman, James E., Tammela, Tuomas, Khan, Omar F., Sood, Sabina, Dave, Apeksha, Cai, Wenxin, Chirino, Leilani M., Yang, Gillian R., Bronson, Roderick, Crowley, Denise G., Sahay, Gaurav, Schroeder, Avi, Langer, Robert, Anderson, Daniel G., Jacks, Tyler

“…MicroRNAs (miRNAs) and siRNAs have enormous potential as cancer therapeutics, but their effective delivery to most solid tumors has been difficult. Here, we…”
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The exploitation of differential endocytic pathways in normal and tumor cells in the selective targeting of nanoparticulate chemotherapeutic agents by Sahay, Gaurav, Kim, Jong Oh, Kabanov, Alexander V, Bronich, Tatiana K

“…Abstract Polymeric micelles with cross-linked ionic cores of poly(methacrylic acid) and nonionic shell of poly(ethylene oxide) ( cl -micelles) are shown here…”
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Multiparametric approach for the evaluation of lipid nanoparticles for siRNA delivery by Alabi, Christopher A., Love, Kevin T., Sahay, Gaurav, Yin, Hao, Luly, Kathryn M., Langer, Robert, Anderson, Daniel G.

“…Nanoparticle-mediated siRNA delivery is a complex process that requires transport across numerous extracellular and intracellular barriers. As such, the…”
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Author Correction: Naturally-occurring cholesterol analogues in lipid nanoparticles induce polymorphic shape and enhance intracellular delivery of mRNA by Patel, Siddharth, Ashwanikumar, N., Robinson, Ema, Xia, Yan, Mihai, Cosmin, Griffith, Joseph P., Hou, Shangguo, Esposito, Adam A., Ketova, Tatiana, Welsher, Kevin, Joyal, John L., Almarsson, Örn, Sahay, Gaurav

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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Neutrophil Responses to Sterile Implant Materials by Jhunjhunwala, Siddharth, Aresta-DaSilva, Stephanie, Tang, Katherine, Alvarez, David, Webber, Matthew J, Tang, Benjamin C, Lavin, Danya M, Veiseh, Omid, Doloff, Joshua C, Bose, Suman, Vegas, Arturo, Ma, Minglin, Sahay, Gaurav, Chiu, Alan, Bader, Andrew, Langan, Erin, Siebert, Sean, Li, Jie, Greiner, Dale L, Newburger, Peter E, von Andrian, Ulrich H, Langer, Robert, Anderson, Daniel G

“…In vivo implantation of sterile materials and devices results in a foreign body immune response leading to fibrosis of implanted material. Neutrophils, one of…”
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