Search Results - "Sahasrabudhe, Parag"

Structural Basis for AMPK Activation: Natural and Synthetic Ligands Regulate Kinase Activity from Opposite Poles by Different Molecular Mechanisms by Calabrese, Matthew F., Rajamohan, Francis, Harris, Melissa S., Caspers, Nicole L., Magyar, Rachelle, Withka, Jane M., Wang, Hong, Borzilleri, Kris A., Sahasrabudhe, Parag V., Hoth, Lise R., Geoghegan, Kieran F., Han, Seungil, Brown, Janice, Subashi, Timothy A., Reyes, Allan R., Frisbie, Richard K., Ward, Jessica, Miller, Russell A., Landro, James A., Londregan, Allyn T., Carpino, Philip A., Cabral, Shawn, Smith, Aaron C., Conn, Edward L., Cameron, Kimberly O., Qiu, Xiayang, Kurumbail, Ravi G.

“…AMP-activated protein kinase (AMPK) is a principal metabolic regulator affecting growth and response to cellular stress. Comprised of catalytic and regulatory…”
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Structural studies identify angiotensin II receptor blocker-like compounds as branched-chain ketoacid dehydrogenase kinase inhibitors by Liu, Shenping, Kormos, Bethany L., Knafels, John D., Sahasrabudhe, Parag V., Rosado, Amy, Sommese, Ruth F., Reyes, Allan R., Ward, Jessica, Roth Flach, Rachel J., Wang, Xiaochun, Buzon, Leanne M., Reese, Matthew R., Bhattacharya, Samit K., Omoto, Kiyoyuki, Filipski, Kevin J.

“…The mammalian mitochondrial branched-chain ketoacid dehydrogenase (BCKD) complex is a multienzyme complex involved in the catabolism of branched-chain amino…”
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Discovery of High-Affinity Small-Molecule Binders of the Epigenetic Reader YEATS4 by Londregan, Allyn T., Aitmakhanova, Karlygash, Bennett, James, Byrnes, Laura J., Canterbury, Daniel P., Cheng, Xiayun, Christott, Thomas, Clemens, Jennifer, Coffey, Steven B., Dias, João M., Dowling, Matthew S., Farnie, Gillian, Fedorov, Oleg, Fennell, Kimberly F., Gamble, Vicki, Gileadi, Carina, Giroud, Charline, Harris, Michael R., Hollingshead, Brett D., Huber, Kilian, Korczynska, Magdalena, Lapham, Kimberly, Loria, Paula M., Narayanan, Arjun, Owen, Dafydd R., Raux, Brigitt, Sahasrabudhe, Parag V., Ruggeri, Roger B., Sáez, Laura Díaz, Stock, Ingrid A., Thuma, Benjamin A., Tsai, Andy, Varghese, Alison E.

“…A series of small-molecule YEATS4 binders have been discovered as part of an ongoing research effort to generate high-quality probe molecules for emerging…”
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Nuances of Arteriovenous Fistula Creation for Vascular Access in Hemodialysis by Sahasrabudhe, Parag, Bindu, Ameya

“…Abstract Background With rising incidence and increased life expectancy of patients with chronic kidney disease (CKD) and end-stage renal disease (ESRD), the…”
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PF-07059013: A Noncovalent Modulator of Hemoglobin for Treatment of Sickle Cell Disease by Gopalsamy, Ariamala, Aulabaugh, Ann E, Barakat, Amey, Beaumont, Kevin C, Cabral, Shawn, Canterbury, Daniel P, Casimiro-Garcia, Agustin, Chang, Jeanne S, Chen, Ming Z, Choi, Chulho, Dow, Robert L, Fadeyi, Olugbeminiyi O, Feng, Xidong, France, Scott P, Howard, Roger M, Janz, Jay M, Jasti, Jayasankar, Jasuja, Reema, Jones, Lyn H, King-Ahmad, Amanda, Knee, Kelly M, Kohrt, Jeffrey T, Limberakis, Chris, Liras, Spiros, Martinez, Carlos A, McClure, Kim F, Narayanan, Arjun, Narula, Jatin, Novak, Jonathan J, O'Connell, Thomas N, Parikh, Mihir D, Piotrowski, David W, Plotnikova, Olga, Robinson, Ralph P, Sahasrabudhe, Parag V, Sharma, Raman, Thuma, Benjamin A, Vasa, Dipy, Wei, Liuqing, Wenzel, A Zane, Withka, Jane M, Xiao, Jun, Yayla, Hatice G

“…Sickle cell disease (SCD) is a genetic disorder caused by a single point mutation (β6 Glu → Val) on the β-chain of adult hemoglobin (HbA) that results in…”
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Indian Perspective of Burnout Among Plastic Surgeons by Karanjkar, Ankur, Panse, Nikhil, Panse, Smita, Sahasrabudhe, Parag

“…Over the last decade, the term has become familiar term in all walks of life, particularly medicine. Emotional exhaustion, depersonalization, and a low sense…”
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Single-Lumen Anastomosis in a Septated Cephalic Vein for Creation of a Proximal AV Fistula by Ravi, Swaminathan, Sahasrabudhe, Parag, Karanjkar, Ankur, Ignatius, Avinash, Khiste, Saurabh

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Reply to the letter to editor by Sahasrabudhe, Parag

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Discovery of First Branched-Chain Ketoacid Dehydrogenase Kinase (BDK) Inhibitor Clinical Candidate PF-07328948 by Filipski, Kevin J., Martinez-Alsina, Luis A., Reese, Matthew R., Evrard, Edelweiss, Buzon, Leanne M., Cameron, Kimberly O., Zhang, Yuan, Coffman, Karen J., Bradow, James, Kormos, Bethany L., Liu, Shenping, Knafels, John D., Sahasrabudhe, Parag V., Chen, Jie, Kalgutkar, Amit S., Bessire, Andrew J., Orozco, Christine C., Balesano, Amanda, Cerny, Matthew A., Bollinger, Eliza, Reyes, Allan R., Laforest, Brigitte, Rosado, Amy, Williams, George, Marshall, Mackenzie, Tam Neale, Kelly, Chen, Xian, Hirenallur-Shanthappa, Dinesh, Stansfield, John C., Groarke, John, Qiu, Ruolun, Karas, Spinel, Roth Flach, Rachel J., Esler, William P.

“…Inhibition of branched-chain ketoacid dehydrogenase kinase (BDK or BCKDK), a negative regulator of branched-chain amino acid (BCAA) metabolism, is hypothesized…”
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Toward the assembly and characterization of an encoded library hit confirmation platform: Bead-Assisted Ligand Isolation Mass Spectrometry (BALI-MS) by Ratnayake, Anokha S., Flanagan, Mark E., Foley, Timothy L., Hultgren, Scott L., Bellenger, Justin, Montgomery, Justin I., Lall, Manjinder S., Liu, Bo, Ryder, Tim, Kölmel, Dominik K., Shavnya, Andre, Feng, Xidong, Lefker, Bruce, Byrnes, Laura J., Sahasrabudhe, Parag V., Farley, Kathleen A., Chen, Shi, Wan, Jinqiao

“…[Display omitted] The ability to predict chemical structure from DNA sequence has to date been a necessary cornerstone of DNA-encoded library technology…”
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Post-CABG Deep Sternal Wound Infection: A Retrospective Comparative Analysis of Early versus Late Referral to a Plastic Surgery Unit in a Tertiary Care Center by Sahasrabudhe, Parag B., Pradhan, Mugdha D., Panse, Nikhil, Jagtap, Ranjit

“…Abstract Background Deep sternal wound infections (DSWI) following median sternotomy are initially treated by the cardiothoracic surgeons and are referred to a…”
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Inhibiting complex IL-17A and IL-17RA interactions with a linear peptide by Liu, Shenping, Desharnais, Joel, Sahasrabudhe, Parag V., Jin, Ping, Li, Wei, Oates, Bryan D., Shanker, Suman, Banker, Mary Ellen, Chrunyk, Boris A., Song, Xi, Feng, Xidong, Griffor, Matt, Jimenez, Judith, Chen, Gang, Tumelty, David, Bhat, Abhijit, Bradshaw, Curt W., Woodnutt, Gary, Lappe, Rodney W., Thorarensen, Atli, Qiu, Xiayang, Withka, Jane M., Wood, Lauren D.

“…IL-17A is a pro-inflammatory cytokine that has been implicated in autoimmune and inflammatory diseases. Monoclonal antibodies inhibiting IL-17A signaling have…”
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Management of Posttraumatic Posterior Elbow Defects by Nonmicrosurgical Reconstruction by Pawar, Manoj Dinkar, Sahasrabudhe, Parag, Panse, Nikhil, Bindu, Ameya Rajan, Phulwer, Rohit Dagadu

“…Abstract Introduction Reconstruction of posterior defects is challenging due to the quality and uniqueness of the excess skin at the elbow that is durable,…”
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Burnout among Plastic Surgery Residents in India: An Observational Study by Panse, Nikhil, Panse, Smita, Ravi, Swaminathan, Mankar, Hemant, Karanjkar, Ankur, Sahasrabudhe, Parag

“…Burnout syndrome can be defined as emotional exhaustion, depersonalization, and perceived lack of personal accomplishment, all of which lead to decreased…”
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Binding site elucidation and structure guided design of macrocyclic IL-17A antagonists by Liu, Shenping, Dakin, Leslie A., Xing, Li, Withka, Jane M., Sahasrabudhe, Parag V., Li, Wei, Banker, Mary Ellen, Balbo, Paul, Shanker, Suman, Chrunyk, Boris A., Guo, Zuojun, Chen, Jinshan M., Young, Jennifer A., Bai, Guoyun, Starr, Jeremy T., Wright, Stephen W., Bussenius, Joerg, Tan, Sheng, Gopalsamy, Ariamala, Lefker, Bruce A., Vincent, Fabien, Jones, Lyn H., Xu, Hua, Hoth, Lise R., Geoghegan, Kieran F., Qiu, Xiayang, Bunnage, Mark E., Thorarensen, Atli

“…Interleukin-17A (IL-17A) is a principal driver of multiple inflammatory and immune disorders. Antibodies that neutralize IL-17A or its receptor (IL-17RA)…”
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Sanitizer burns: An alcoholic problem by Ravi, Swaminathan, Phulwar, Rohit, Panse, Nikhil, Sahasrabudhe, Parag

“…The use of alcohol-based sanitizer solutions has become ubiquitous during the COVID-19 epidemic. However, the public at large is not aware of the hazards…”
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Free style perforator based propeller flaps: Simple solutions for upper extremity reconstruction by Panse, Nikhil, Sahasrabudhe, Parag

“…The introduction of perforator flaps by Koshima et al. was met with much animosity in the plastic surgery fraternity. The safety concerns of these flaps…”
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Limb salvage with microvascular free fibula following primary bone sarcoma resection by Parag, Sahasrabudhe, Yogesh, Panchwagh, Rathod, Jesal, Nikhil, Panse, Amit, Jadhav

“…Background: Extremity sarcomas are challenging to manage. Total eradication of tumour has to be balanced with restoration of limb function to prevent mortality…”
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Structural basis for CCR6 modulation by allosteric antagonists by Wasilko, David Jonathan, Gerstenberger, Brian S., Farley, Kathleen A., Li, Wei, Alley, Jennifer, Schnute, Mark E., Unwalla, Ray J., Victorino, Jorge, Crouse, Kimberly K., Ding, Ru, Sahasrabudhe, Parag V., Vincent, Fabien, Frisbie, Richard K., Dermenci, Alpay, Flick, Andrew, Choi, Chulho, Chinigo, Gary, Mousseau, James J., Trujillo, John I., Nuhant, Philippe, Mondal, Prolay, Lombardo, Vincent, Lamb, Daniel, Hogan, Barbara J., Minhas, Gurdeep Singh, Segala, Elena, Oswald, Christine, Windsor, Ian W., Han, Seungil, Rappas, Mathieu, Cooke, Robert M., Calabrese, Matthew F., Berstein, Gabriel, Thorarensen, Atli, Wu, Huixian

“…The CC chemokine receptor 6 (CCR6) is a potential target for chronic inflammatory diseases. Previously, we reported an active CCR6 structure in complex with…”
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Biophysical Characterization of the Complex between Double-Stranded RNA and the N-Terminal Domain of the NS1 Protein from Influenza A Virus:  Evidence for a Novel RNA-Binding Mode by Chien, Chen-ya, Xu, Yujia, Xiao, Rong, Aramini, James M, Sahasrabudhe, Parag V, Krug, Robert M, Montelione, Gaetano T

“…The influenza virus nonstructural protein 1 encoded by influenza A virus (NS1A protein) is a multifunctional protein involved in both protein−protein and…”
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