Search Results - "Sahakian, Eva"

A Novel Chemoimmunomodulating Property of Docetaxel: Suppression of Myeloid-Derived Suppressor Cells in Tumor Bearers by KODUMUDI, Krithika N, WOAN, Karrune, GILVARY, Danielle L, SAHAKIAN, Eva, SHENG WEI, DJEU, Julie Y

“…Myeloid-derived suppressor cells (MDSC) accumulate in tumor-bearing hosts and are associated with immune suppression. To date, there have only been few studies…”
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Regulatory T cells (Tregs) in lymphoid malignancies and the impact of novel therapies by Maharaj, Kamira, Uriepero, Angimar, Sahakian, Eva, Pinilla-Ibarz, Javier

“…Regulatory T cells (Tregs) are responsible for maintaining immune homeostasis by controlling immune responses. They can be characterized by concomitant…”
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Optimization of In Vitro Th17 Polarization for Adoptive Cell Therapy in Chronic Lymphocytic Leukemia by Gamal, Wael, Mediavilla-Varela, Melanie, Uriepero-Palma, Angimar, Pinilla-Ibarz, Javier, Sahakian, Eva

“…Although preclinical investigations have shown notable efficacy in solid tumor models utilizing in vitro-differentiated Th17 cells for adoptive cell therapy…”
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The PIM1 Kinase Is a Critical Component of a Survival Pathway Activated by Docetaxel and Promotes Survival of Docetaxel-treated Prostate Cancer Cells by Zemskova, Marina, Sahakian, Eva, Bashkirova, Svetlana, Lilly, Michael

“…A defining characteristic of solid tumors is the capacity to divide aggressively and disseminate under conditions of nutrient deprivation, limited oxygen…”
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Mycovirus-Containing Aspergillus flavus Alters Transcription Factors in Normal and Acute Lymphoblastic Leukemia Cells by Tebbi, Cameron K, Yan, Jiyu, Sahakian, Eva, Mediavilla-Varela, Melanie, Pinilla-Ibarz, Javier, Patel, Saumil, Rottinghaus, George E, Liu, Rachel Y, Dennison, Clare

“…Transcription factors control genes to maintain normal hemopoiesis, and dysregulation of some factors can lead to acute lymphoblastic leukemia (ALL)…”
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A novel role for histone deacetylase 6 in the regulation of the tolerogenic STAT3/IL-10 pathway in APCs by Cheng, Fengdong, Lienlaf, Maritza, Wang, Hong-Wei, Perez-Villarroel, Patricio, Lee, Calvin, Woan, Karrune, Rock-Klotz, Jennifer, Sahakian, Eva, Woods, David, Pinilla-Ibarz, Javier, Kalin, Jay, Tao, Jianguo, Hancock, Wayne, Kozikowski, Alan, Seto, Edward, Villagra, Alejandro, Sotomayor, Eduardo M

“…APCs are critical in T cell activation and in the induction of T cell tolerance. Epigenetic modifications of specific genes in the APC play a key role in this…”
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Essential role for histone deacetylase 11 (HDAC11) in neutrophil biology by Sahakian, Eva, Chen, Jie, Powers, John J., Chen, Xianghong, Maharaj, Kamira, Deng, Susan L., Achille, Alex N., Lienlaf, Maritza, Wang, Hong Wei, Cheng, Fengdong, Sodré, Andressa L., Distler, Allison, Xing, Limin, Perez‐Villarroel, Patricio, Wei, Sheng, Villagra, Alejandro, Seto, Ed, Sotomayor, Eduardo M., Horna, Pedro, Pinilla‐Ibarz, Javier

“…Expression of HDAC11 may be involved in myeloid cell biology. Epigenetic changes in chromatin structure have been recently associated with the deregulated…”
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HDAC6 Inhibition Alleviates CLL-Induced T-Cell Dysfunction and Enhances Immune Checkpoint Blockade Efficacy in the Eμ-TCL1 Model by Maharaj, Kamira, Powers, John J, Mediavilla-Varela, Melanie, Achille, Alex, Gamal, Wael, Quayle, Steven, Jones, Simon S, Sahakian, Eva, Pinilla-Ibarz, Javier

“…Development of chronic lymphocytic leukemia (CLL) is associated with severe immune dysfunction. T-cell exhaustion, immune checkpoint upregulation, and increase…”
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Docetaxel-induced prostate cancer cell death involves concomitant activation of caspase and lysosomal pathways and is attenuated by LEDGF/p75 by Mediavilla-Varela, Melanie, Pacheco, Fabio J, Almaguel, Frankis, Perez, Jossymar, Sahakian, Eva, Daniels, Tracy R, Leoh, Lai Sum, Padilla, Amelia, Wall, Nathan R, Lilly, Michael B, De Leon, Marino, Casiano, Carlos A

“…Hormone-refractory prostate cancer (HRPC) is characterized by poor response to chemotherapy and high mortality, particularly among African American men when…”
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Emerging role of BCR signaling inhibitors in immunomodulation of chronic lymphocytic leukemia by Maharaj, Kamira, Sahakian, Eva, Pinilla-Ibarz, Javier

“…Approved therapies that target the B-cell receptor (BCR) signaling pathway, such as ibrutinib and idelalisib, are known to show activity in chronic lymphocytic…”
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IL-7 Dependence in Human B Lymphopoiesis Increases during Progression of Ontogeny from Cord Blood to Bone Marrow by Parrish, Yasmin Khan, Baez, Ineavely, Milford, Terry-Ann, Benitez, Abigail, Galloway, Nicholas, Rogerio, Jaqueline Willeman, Sahakian, Eva, Kagoda, Mercy, Huang, Grace, Hao, Qian-Lin, Sevilla, Yazmar, Barsky, Lora W, Zielinska, Ewa, Price, Mary A, Wall, Nathan R, Dovat, Sinisa, Payne, Kimberly J

“…IL-7 is critical for B cell production in adult mice; however, its role in human B lymphopoiesis is controversial. One challenge was the inability to…”
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Induction of clusterin by AKT--role in cytoprotection against docetaxel in prostate tumor cells by Zhong, Bin, Sallman, David A, Gilvary, Danielle L, Pernazza, Daniele, Sahakian, Eva, Fritz, Dillon, Cheng, Jin Q, Trougakos, Ioannis, Wei, Sheng, Djeu, Julie Y

“…Clusterin (CLU), in its cytoplasmic form, is abundant in many advanced cancers and has been established to be cytoprotective against chemotherapeutic agents…”
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Exposure to a mycovirus containing Aspergillus Flavus reproduces acute lymphoblastic leukemia cell surface and genetic markers in cells from patients in remission and not controls by Tebbi, Cameron K., Badiga, Aruna, Sahakian, Eva, Powers, John J., Achille, Alex N., Patel, Saumil, Migone, Felicia

“…•A mycovirus containing Aspergillus Flavus (MCAF) was cultured from the home of a patient with acute lymphoblastic leukemia (ALL).•Culture was evaluated by…”
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Stat3 Inhibition Augments the Immunogenicity of B-cell Lymphoma Cells, Leading to Effective Antitumor Immunity by FENGDONG CHENG, HONGWEI WANG, SMITH, Mitchell, JIANGUO TAO, SOTOMAYOR, Eduardo M, HORNA, Pedro, ZI WANG, SHAH, Bijal, SAHAKIAN, Eva, WOAN, Karrune V, VILLAGRA, Alejandro, PINILLA-IBARZ, Javier, SEBTI, Said

“…Mantle cell lymphoma (MCL) is an aggressive and incurable subtype of B-cell non-Hodgkin lymphomas. Although patients often respond initially to first-line…”
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Comment on "Association between Residential Proximity to Viticultural Areas and Childhood Acute Leukemia Risk in Mainland France: GEOCAP Case-Control Study, 2006-2013" by Tebbi, Cameron K, Sahakian, Eva

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The role of Th17 cells in chronic lymphocytic leukemia: friend or foe? by Gamal, Wael, Sahakian, Eva, Pinilla-Ibarz, Javier

“…[Display omitted] T helper 17 (Th17) cells have a prominent role in autoimmune diseases. In contrast, the nature of these cells in cancer is controversial,…”
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Metabolic Abnormalities Associated with T-Cell Exhaustion in CLL Eµ-TCL1 Murine Model by Gamal, Wael, Mediavilla-Varela, Melanie, Maharaj, Kamira, Uriepero, Angimar, Kunta, Vishaal, Sahakian, Eva, Pinilla Ibarz, Javier

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Selective HDAC6 inhibitors improve anti-PD-1 immune checkpoint blockade therapy by decreasing the anti-inflammatory phenotype of macrophages and down-regulation of immunosuppressive proteins in tumor cells by Knox, Tessa, Sahakian, Eva, Banik, Debarati, Hadley, Melissa, Palmer, Erica, Noonepalle, Satish, Kim, Jennifer, Powers, John, Gracia-Hernandez, Maria, Oliveira, Vasco, Cheng, Fengdong, Chen, Jie, Barinka, Cyril, Pinilla-Ibarz, Javier, Lee, Norman H., Kozikowski, Alan, Villagra, Alejandro

“…Histone deacetylases (HDACs) are involved in diverse cellular regulatory mechanisms including non-canonical functions outside the chromatin environment…”
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Efficacy of Combinatorial Treatment Approaches in CTCL by Mediavilla-Varela, Melanie, Sahakian, Eva, Harro, Carly, Powers, John J., Conejo-Garcia, Jose, Sokol, Lubomir, Pinilla Ibarz, Javier

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A phase I clinical trial of ruxolitinib in combination with nilotinib in chronic myeloid leukemia patients with molecular evidence of disease by Sweet, Kendra, Hazlehurst, Lori, Sahakian, Eva, Powers, John, Nodzon, Lisa, Kayali, Fadi, Hyland, Kelly, Nelson, Ashley, Pinilla-Ibarz, Javier

“…•Inhibition of pSTAT3 may alter the bone marrow and sensitize CML stem cells to TKI.•Ruxolitinib and nilotinib can be safely combined in patients with…”
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