Search Results - "Sahai, Vaibhav"

Pemigatinib for previously treated, locally advanced or metastatic cholangiocarcinoma: a multicentre, open-label, phase 2 study by Abou-Alfa, Ghassan K, Sahai, Vaibhav, Hollebecque, Antoine, Vaccaro, Gina, Melisi, Davide, Al-Rajabi, Raed, Paulson, Andrew S, Borad, Mitesh J, Gallinson, David, Murphy, Adrian G, Oh, Do-Youn, Dotan, Efrat, Catenacci, Daniel V, Van Cutsem, Eric, Ji, Tao, Lihou, Christine F, Zhen, Huiling, Féliz, Luis, Vogel, Arndt

“…Fibroblast growth factor receptor (FGFR) 2 gene alterations are involved in the pathogenesis of cholangiocarcinoma. Pemigatinib is a selective, potent, oral…”
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Metastatic Pancreatic Cancer: ASCO Guideline Update by Sohal, Davendra P.S., Kennedy, Erin B., Cinar, Pelin, Conroy, Thierry, Copur, Mehmet S., Crane, Christopher H., Garrido-Laguna, Ignacio, Lau, Michelle W., Johnson, Tyler, Krishnamurthi, Smitha, Moravek, Cassadie, O’Reilly, Eileen M., Philip, Philip A., Pant, Shubham, Shah, Manish A., Sahai, Vaibhav, Uronis, Hope E., Zaidi, Neeha, Laheru, Daniel

“…PURPOSE The aim of this work was to provide an update to the ASCO guideline on metastatic pancreatic cancer pertaining to recommendations for therapy options…”
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GM-CSF Mediates Mesenchymal-Epithelial Cross-talk in Pancreatic Cancer by Waghray, Meghna, Yalamanchili, Malica, Dziubinski, Michele, Zeinali, Mina, Erkkinen, Marguerite, Yang, Huibin, Schradle, Kara A, Urs, Sumithra, Pasca Di Magliano, Marina, Welling, Theodore H, Palmbos, Phillip L, Abel, Ethan V, Sahai, Vaibhav, Nagrath, Sunitha, Wang, Lidong, Simeone, Diane M

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by a dense stroma consisting of a prevalence of activated fibroblasts whose functional contributions to…”
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Immunotherapy for pancreatic ductal adenocarcinoma by Carpenter, Eileen, Nelson, Sarah, Bednar, Filip, Cho, Clifford, Nathan, Hari, Sahai, Vaibhav, Magliano, Marina Pasca, Frankel, Timothy L.

“…Pancreatic ductal adenocarcinoma (PDAC) remains a lethal cancer with an urgent need for better medical therapies. Efforts have been made to investigate the…”
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BET bromodomain inhibitors block growth of pancreatic cancer cells in three-dimensional collagen by Sahai, Vaibhav, Kumar, Krishan, Knab, Lawrence M, Chow, Christina R, Raza, Sania S, Bentrem, David J, Ebine, Kazumi, Munshi, Hidayatullah G

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with pronounced fibrosis that contributes to chemoresistance, in part, through increased histone…”
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Integrated Workflow for the Label-Free Isolation and Genomic Analysis of Single Circulating Tumor Cells in Pancreatic Cancer by Rupp, Brittany, Owen, Sarah, Ball, Harrison, Smith, Kaylee Judith, Gunchick, Valerie, Keller, Evan T, Sahai, Vaibhav, Nagrath, Sunitha

“…As pancreatic cancer is the third deadliest cancer in the U.S., the ability to study genetic alterations is necessary to provide further insight into…”
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A Comparison of Spatial and Phenotypic Immune Profiles of Pancreatic Ductal Adenocarcinoma and Its Precursor Lesions by Enzler, Thomas, Shi, Jiaqi, McGue, Jake, Griffith, Brian D, Sun, Lei, Sahai, Vaibhav, Nathan, Hari, Frankel, Timothy L

“…Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with a 5-year survival rate of 12.5%. PDAC predominantly arises from non-cystic pancreatic…”
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Bone marrow edema associated with everolimus by McDevitt, Rachel Lebovic, Quinlan, Chelsey, Hersberger, Katie, Sahai, Vaibhav

“…PURPOSE.The case of a patient who experienced bone marrow edema and pain in both feet and a compression fracture of one heel bone after several months of…”
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Three-dimensional collagen I promotes gemcitabine resistance in vitro in pancreatic cancer cells through HMGA2-dependent histone acetyltransferase expression by Dangi-Garimella, Surabhi, Sahai, Vaibhav, Ebine, Kazumi, Kumar, Krishan, Munshi, Hidayatullah G

“…Pancreatic ductal adenocarcinoma (PDAC) is associated with a pronounced collagen-rich stromal reaction that has been shown to contribute to chemo-resistance…”
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Epidermal Growth Factor Receptor Expression and Gene Copy Number in Conventional Hepatocellular Carcinoma by BUCKLEY, Anne F, BURGART, Lawrence J, SAHAI, Vaibhav, KAKAR, Sanjay

“…Epidermal growth factor receptor (EGFR) is frequently overexpressed in hepatocellular carcinoma, but its relationship with EGFR gene copy number has not been…”
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Genomics driven precision oncology in advanced biliary tract cancer improves survival by Kumar-Sinha, Chandan, Vats, Pankaj, Tran, Nguyen, Robinson, Dan R., Gunchick, Valerie, Wu, Yi-Mi, Cao, Xuhong, Ning, Yu, Wang, Rui, Rabban, Erica, Bell, Janice, Shankar, Sunita, Mannan, Rahul, Zhang, Yuping, Zalupski, Mark M., Chinnaiyan, Arul M., Sahai, Vaibhav

“…•Biliary tract cancers (BTCs), including intrahepatic, perihilar, and distal cholangiocarcinoma as well as gallbladder cancer are rare but aggressive…”
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S82 Longitudinal Immunoprofiling of Pancreatic Cancer Patients to Identify Mediators of Therapy Resistance by Carpenter, Eileen, Kemp, Samantha, Kadiyala, Padma, Steele, Nina, Elhossiny, Ahmed, Sirihorachai, Veerin, Du, Wenting, Espinoza, Carlos, The, Stephanie, Freeman, Julia, Bhalla, Sean, Singhvi, Ajay, Anderson, Michelle, Kwon, Richard, Wamsteker, Erik-Jan, Prabhu, Anoop, Schulman, Allison, Gunchick, Valerie, Sahai, Vaibhav, Frankel, Timothy, Bednar, Filip, Di Magliano, Marina Pasca

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ATM-deficiency increases genomic instability and metastatic potential in a mouse model of pancreatic cancer by Drosos, Yiannis, Escobar, David, Chiang, Ming-Yi, Roys, Kathryn, Valentine, Virginia, Valentine, Marc B., Rehg, Jerold E., Sahai, Vaibhav, Begley, Lesa A., Ye, Jianming, Paul, Leena, McKinnon, Peter J., Sosa-Pineda, Beatriz

“…Germline mutations in ATM (encoding the DNA-damage signaling kinase, ataxia-telangiectasia-mutated) increase Familial Pancreatic Cancer (FPC) susceptibility,…”
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A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer by Hu, Zishuo Ian, Bendell, Johanna C., Bullock, Andrea, LoConte, Noelle K., Hatoum, Hassan, Ritch, Paul, Hool, Hugo, Leach, Joseph W., Sanchez, James, Sohal, Davendra P. S., Strickler, John, Patel, Ravindranath, Wang‐Gillam, Andrea, Firdaus, Irfan, Yu, Kenneth H., Kapoun, Ann M., Holmgren, Eric, Zhou, Lei, Dupont, Jakob, Picozzi, Vincent, Sahai, Vaibhav, O'Reilly, Eileen M.

“…Purpose Notch signaling dysregulation is implicated in the development of pancreatic adenocarcinoma (PDAC). Tarextumab is a fully human IgG2 antibody that…”
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Synergistic Analysis of Circulating Tumor Cells Reveals Prognostic Signatures in Pilot Study of Treatment-Naïve Metastatic Pancreatic Cancer Patients by Owen, Sarah, Prantzalos, Emily, Gunchick, Valerie, Sahai, Vaibhav, Nagrath, Sunitha

“…Pancreatic ductal adenocarcinoma is typically diagnosed at late stages and has one of the lowest five-year survival rates of all malignancies. In this pilot…”
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Epidermal growth factor receptor and HER-2/neu status by immunohistochemistry and fluorescence in situ hybridization in adenocarcinomas of the biliary tree and gallbladder by Shafizadeh, Nafis, MD, Grenert, James P., MD, PhD, Sahai, Vaibhav, MD, Kakar, Sanjay, MD

“…Summary Adenocarcinomas of the biliary tract and gallbladder are aggressive tumors with a poor prognosis. Standard chemotherapy often offers minimal benefit…”
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Pancreatic cancer is marked by complement-high blood monocytes and tumor-associated macrophages by Kemp, Samantha B, Steele, Nina G, Carpenter, Eileen S, Donahue, Katelyn L, Bushnell, Grace G, Morris, Aaron H, The, Stephanie, Orbach, Sophia M, Sirihorachai, Veerin R, Nwosu, Zeribe C, Espinoza, Carlos, Lima, Fatima, Brown, Kristee, Girgis, Alexander A, Gunchick, Valerie, Zhang, Yaqing, Lyssiotis, Costas A, Frankel, Timothy L, Bednar, Filip, Rao, Arvind, Sahai, Vaibhav, Shea, Lonnie D, Crawford, Howard C, Pasca di Magliano, Marina

“…Pancreatic ductal adenocarcinoma (PDA) is accompanied by reprogramming of the local microenvironment, but changes at distal sites are poorly understood. We…”
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Irinotecan-associated dysarthria: A single institution case series with management implications in patients with gastrointestinal malignancies by Zhen, David B, McDevitt, Rachel L, Zalupski, Mark M, Sahai, Vaibhav

“…Irinotecan (Camptosar©, CPT-11), a topoisomerase I inhibitor, is a commonly used cytotoxic chemotherapeutic in the treatment of multiple malignancies,…”
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Retrospective Cohort Analysis of Aspirin Use and Venous Thromboembolism in Patients with Pancreatic Cancer and an Indwelling Central Venous Catheter by King, Richard, Schaefer, Jordan, Sahai, Vaibhav, Griffith, Kent A., Sood, Suman L.

“…Abstract Background  Patients with pancreatic cancer are at high risk of developing venous thromboembolism (VTE). It is unknown if aspirin reduces the risk of…”
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Predictors of Acute and Late Toxicity in Patients Receiving Chemoradiation for Unresectable Pancreatic Cancer by Das, Rishi, Hadley, Scott, Sahai, Vaibhav, Bednar, Filip, Evans, Joseph, Lawrence, Theodore, Cuneo, Kyle, Abbott, Madeline R., Schipper, Matt

“…Patients with pancreatic cancer undergoing chemoradiation therapy may experience acute and chronic side effects. We conducted an exploratory analysis of…”
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