Search Results - "Sagot, Y"

IAP family proteins delay motoneuron cell death in vivo by Perrelet, D., Ferri, A., MacKenzie, A. E., Smith, G. M., Korneluk, R. G., Liston, P., Sagot, Y., Terrado, J., Monnier, D., Kato, A. C.

“…Neuronal apoptosis inhibitory protein (NAIP), and human inhibitors of apoptosis 1 and 2 (HIAP1 and HIAP2) are three members of the mammalian family of…”
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Beneficial effects of r-h-CLU on disease severity in different animal models of peripheral neuropathies by Dati, G, Quattrini, A, Bernasconi, L, Malaguti, M.C, Antonsson, B, Nicoletti, F, Alliod, C, Di Marco, R, Sagot, Y, Vitte, P.A, Hiver, A, Greco, B, Roach, A, Zaratin, P.F

“…Abstract Clusterin is a protein involved in multiple biological events, including neuronal cytoprotection, membrane recycling and regulation of…”
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Bcl-2 overexpression prevents motoneuron cell body loss but not axonal degeneration in a mouse model of a neurodegenerative disease by Sagot, Y, Dubois-Dauphin, M, Tan, SA, de Bilbao, F, Aebischer, P, Martinou, JC, Kato, AC

“…Bcl-2 and its analogs protect different classes of neurons from apoptosis in several experimental situations. These proteins may therefore provide a means for…”
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GDNF slows loss of motoneurons but not axonal degeneration or premature death of pmn/pmn mice by Sagot, Y, Tan, SA, Hammang, JP, Aebischer, P, Kato, AC

“…Glial cell line-derived neurotrophic factor (GDNF), a member of the TG F-beta superfamily, has been shown to be a highly potent neurotrophic factor that…”
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Quantitative comparison of the transient rescue effects of neurotrophic factors on axotomized motoneurons in vivo by Vejsada, R, Sagot, Y, Kato, A C

“…A reproducible neuronal degeneration induced by nerve lesion in neonatal rats or mice provides a convenient in vivo assay for testing the survival-promoting…”
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Polymer encapsulated cell lines genetically engineered to release ciliary neurotrophic factor can slow down progressive motor neuronopathy in the mouse by Sagot, Y, Tan, S A, Baetge, E, Schmalbruch, H, Kato, A C, Aebischer, P

“…Ciliary neurotrophic factor (CNTF) has recently generated great interest due to its potential as a therapeutic agent for the treatment of human…”
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An orally active anti‐apoptotic molecule (CGP 3466B) preserves mitochondria and enhances survival in an animal model of motoneuron disease by Sagot, Y, Toni, N, Perrelet, D, Lurot, S, King, B, Rixner, H, Mattenberger, L, Waldmeier, P C, Kato, A C

“…Apoptosis and mitochondrial dysfunction are thought to be involved in the aetiology of neurodegenerative diseases. We have tested an orally active…”
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Phosphatidylinositol 3-kinase activity in murine motoneuron disease: the progressive motor neuropathy mouse by Wagey, R, Lurot, S, Perrelet, D, Pelech, S.L, Sagot, Y, Krieger, C

“…A murine model of motoneuron disease, the pmn/pmn mouse, shows a reduction in the retrograde transport of fluorescent probes applied directly onto the cut end…”
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Antibodies directed against the β1-integrin subunit and peptides containing the IKVAV sequence of laminin perturb neurite outgrowth of peripheral neurons on immature spinal cord substrata by Agius, E., Sagot, Y., Duprat, A.M., Cochard, P.

“…Neuron-substratum interactions regulating axon growth in the developing central nervous system of the rat have been studied by means of an in vitro bioassay:…”
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Injury-induced synthesis and release of apolipoprotein E and clusterin from rat neural cells by Messmer-Joudrier, S, Sagot, Y, Mattenberger, L, James, R W, Kato, A C

“…Apolipoproteins in the brain have assumed major clinical importance since it was shown that one of the allelic forms of apolipoprotein E, apoE-4, is a risk…”
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Long-lasting accumulation of hemopexin in permanently transected peripheral nerves and its down-regulation during regeneration by Madore, N, Sagot, Y, Guinaudy, M J, Cochard, P, Swerts, J P

“…We have previously demonstrated that hemopexin is present in the intact sciatic nerve and is overproduced in the distal stump after nerve transection (Swerts…”
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Hemopexin is synthesized in peripheral nerves but not in central nervous system and accumulates after axotomy by SWERTS, J.-P, SOULA, C, SAGOT, Y, GUINAUDY, M.-J, GUILLEMOT, J.-C, FERRARA, P, DUPRAT, A.-M, COCHARD, P

“…In adult mammals, injured axons regrow over long distances in peripheral nerves but fail to do so in the central nervous system. Analysis of molecular…”
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Astroglial differentiation from neuroepithelial precursor cells of amphibian embryos: an in vivo and in vitro analysis by Soula, C, Sagot, Y, Cochard, P, Duprat, A M

“…Initial development of astroglial phenotype has been studied in vitro in an amphibian embryo (Pleurodeles waltI), to document the differentiation…”
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IKK2 Inhibitor Alleviates Kidney and Wasting Diseases in a Murine Model of Human AIDS by Heckmann, Angélique, Waltzinger, Caroline, Jolicoeur, Paul, Dreano, Michel, Kosco-Vilbois, Marie H., Sagot, Yves

“…Wasting and renal diseases are frequent complications of HIV (human immunodeficiency virus) infection and are associated with accelerated disease progression…”
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Differential Effects of Neurotrophic Factors on Motoneuron Retrograde Labeling in a Murine Model of Motoneuron Disease by Sagot, Yves, Rosse, Thierry, Vejsada, Richard, Perrelet, Daniel, Kato, Ann C

“…It has been shown that abnormalities in axonal transport occur in several mouse models with motoneuron degeneration and also in the human disease amyotrophic…”
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Clinical and molecular aspects of motoneurone diseases: animal models, neurotrophic factors and Bcl-2 oncoprotein by Sagot, Y, Vejsada, R., Kato, A.C.

“…Animal models of motor neurone disease (MND) are being increasingly used for screening molecules with clinical potential. A number of different treatments to…”
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Antibodies directed against the beta 1-integrin subunit and peptides containing the IKVAV sequence of laminin perturb neurite outgrowth of peripheral neurons on immature spinal cord substrata by Agius, E, Sagot, Y, Duprat, A M, Cochard, P

“…Neuron-substratum interactions regulating axon growth in the developing central nervous system of the rat have been studied by means of an in vitro bioassay:…”
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BDNF-mediated rescue of axotomized motor neurones decreases with increasing dose by Vejsada, R, Sagot, Y, Kato, A C

“…Direct application of brain-derived neurotrophic factor (BDNF) to the cut end of axotomized immature motor neurones had only transient survival-promoting…”
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NGF-induced motoneuron cell death depends on the genetic background and motoneuron sub-type by Terrado, José, Monnier, Dominique, Perrelet, Daniel, Sagot, Yves, Mattenberger, Louki, King, Béatrice, Kato, Ann C

“…Nerve growth factor (NGF) promotes the survival of several neuronal populations, but recently it has also been shown to induce neuronal cell death. Here we…”
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Changes in permissivity for neuronal attachment and neurite outgrowth of spinal cord grey and white matters during development: a study with the 'cryoculture' bioassay by Sagot, Y, Swerts, J P, Cochard, P

“…We have used the recently developed cryoculture bioassay (Carbonetto et al., J. Neurosci., 7 (1987) 610-620) to document changes during development of CNS…”
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