Search Results - "Sagiv, Yuval"

Lysosomal Glycosphingolipid Recognition by NKT Cells by Zhou, Dapeng, Mattner, Jochen, Cantu, Carlos, Schrantz, Nicolas, Yin, Ning, Gao, Ying, Sagiv, Yuval, Hudspeth, Kelly, Wu, Yun-Ping, Yamashita, Tadashi, Teneberg, Susann, Wang, Dacheng, Proia, Richard L., Levery, Steven B., Savage, Paul B., Teyton, Luc, Bendelac, Albert

“…NKT cells represent a distinct lineage of T cells that coexpress a conserved αβ T cell receptor (TCR) and natural killer (NK) receptors. Although the TCR of…”
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The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells by Schrantz, Nicolas, Sagiv, Yuval, Liu, Yang, Savage, Paul B, Bendelac, Albert, Teyton, Luc

“…The Niemann-Pick type C2 (NPC2) protein is a small, soluble, lysosomal protein important for cholesterol and sphingolipid transport in the lysosome. The…”
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Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen αGalCer by Bai, Li, Sagiv, Yuval, Liu, Yang, Freigang, Stefan, Yu, Karl O.A, Teyton, Luc, Porcelli, Steven A, Savage, Paul B, Bendelac, Albert

“…Short or polyunsaturated lipid variants of the NKT cell antigen α-galactosylceramide (αGC) exhibit decreased potency and a Th2 bias in vivo despite conserved…”
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Editing of CD1d-Bound Lipid Antigens by Endosomal Lipid Transfer Proteins by Zhou, Dapeng, Cantu, Carlos, Sagiv, Yuval, Schrantz, Nicolas, Kulkarni, Ashok B., Qi, Xiaoyang, Mahuran, Don J., Morales, Carlos R., Grabowski, Gregory A., Benlagha, Kamel, Savage, Paul, Bendelac, Albert, Teyton, Luc

“…It is now established that CD1 molecules present lipid antigens to T cells, although it is not clear how the exchange of lipids between membrane compartments…”
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A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d by Sagiv, Yuval, Bai, Li, Wei, Datsen G, Agami, Reuven, Savage, Paul B, Teyton, Luc, Bendelac, Albert

“…Microsomal triglyceride transfer protein (MTP) is an endoplasmic reticulum (ER)-resident lipid transfer protein involved in the biosynthesis and lipid loading…”
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The COOH Terminus of GATE-16, an Intra-Golgi Transport Modulator, Is Cleaved by the Human Cysteine Protease HsApg4A by Scherz-Shouval, Ruth, Sagiv, Yuval, Shorer, Hagai, Elazar, Zvulun

“…Docking of a vesicle at the appropriate target membrane involves an interaction between integral membrane proteins located on the vesicle (v-SNAREs) and those…”
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Sequential SNARE Disassembly and GATE-16-GOS-28 Complex Assembly Mediated by Distinct NSF Activities Drives Golgi Membrane Fusion by Joyce M. M. Müller, Shorter, James, Newman, Richard, Deinhardt, Katrin, Sagiv, Yuval, Elazar, Zvulun, Warren, Graham, Shima, David T.

“…Characterization of mammalian NSF (G274E) and Drosophila NSF (comatose) mutants revealed an evolutionarily conserved NSF activity distinct from…”
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Aut7p, a Soluble Autophagic Factor, Participates in Multiple Membrane Trafficking Processes by Legesse-Miller, Aster, Sagiv, Yuval, Glozman, Rina, Elazar, Zvulun

“…Aut7p, a protein recently implicated in autophagic events in the yeast Saccharomyces cerevisiae, exhibits significant homology to a mammalian protein, p16,…”
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A 56-kDa Selenium-binding Protein Participates in Intra-Golgi Protein Transport by Porat, Amir, Sagiv, Yuval, Elazar, Zvulun

“…Transport of proteins between intracellular membrane compartments is a highly regulated process that depends on several cytosolic factors. By using the well…”
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Isolation and Characterization of a Novel Low Molecular Weight Protein Involved in Intra-Golgi Traffic by Legesse-Miller, A, Sagiv, Y, Porat, A, Elazar, Z

“…Analysis of the cytosolic requirements for in vitro intra-Golgi transport led to the characterization of three proteins: N -ethylmaleimide-sensitive fusion…”
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Distinct anti-inflammatory properties of alpha1-antitrypsin and corticosteroids reveal unique underlying mechanisms of action by Schuster, Ronen, Motola-Kalay, Noa, Baranovski, Boris M., Bar, Liliana, Tov, Naveh, Stein, Michal, Lewis, Eli C., Ayalon, Michal, Sagiv, Yuval

“…•AAT results in cytokine shift to resolution as opposed to pan-suppression using Dex.•AAT requires intact NF-κB–p65 activity to amplify LPS-induced IL-1Ra…”
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Apoptosis as a mechanism of T-regulatory cell homeostasis and suppression by Yolcu, Esma S, Ash, Shifra, Kaminitz, Ayelet, Sagiv, Yuval, Askenasy, Nadir, Yarkoni, Shai

“…Activation‐induced cell death is a general mechanism of immune homeostasis through negative regulation of clonal expansion of activated immune cells. This…”
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Involvement of IL-2 in homeostasis of regulatory T cells: the IL-2 cycle by Yarkoni, Shai, Kaminitz, Ayelet, Sagiv, Yuval, Yaniv, Isaac, Askenasy, Nadir

“…A large body of evidence on the activity of regulatory T (Treg) cells was gathered during the last decade, and a similar number of reviews and opinion papers…”
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Cutting Edge: Impaired Glycosphingolipid Trafficking and NKT Cell Development in Mice Lacking Niemann-Pick Type C1 Protein by Sagiv, Yuval, Hudspeth, Kelly, Mattner, Jochen, Schrantz, Nicolas, Stern, Randi K, Zhou, Dapeng, Savage, Paul B, Teyton, Luc, Bendelac, Albert

“…Niemann-Pick type C1 (NPC1) is a late endosomal/lysosomal transmembrane protein involved in the cellular transport of glycosphingolipids and cholesterol that…”
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GATE-16, a membrane transport modulator, interacts with NSF and the Golgi v-SNARE GOS-28 by Sagiv, Yuval, Legesse-Miller, Aster, Porat, Amir, Elazar, Zvulun

“…Membrane proteins located on vesicles (v‐SNAREs) and on the target membrane (t‐SNAREs) mediate specific recognition and, possibly, fusion between a transport…”
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Targeted therapy to the IL-2R using diphtheria toxin and caspase-3 fusion proteins modulates Treg and ameliorates inflammatory colitis by Yarkoni, Shai, Sagiv, Yuval, Kaminitz, Ayelet, Farkas, Daniel L, Askenasy, Nadir

“…Pathogenic lymphocytes in the enteric wall of inflammatory bowel disease patients display various abnormalities, including reduced sensitivity to apoptosis. We…”
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A Fusion Protein Composed of IL-2 and Caspase-3 Ameliorates the Outcome of Experimental Inflammatory Colitis by Sagiv, Yuval, Kaminitz, Ayelet, Lorberboum-Galski, Haya, Askenasy, Nadir, Yarkoni, Shai

“…Targeted depletion of immune cells expressing the interleukin‐2 (IL‐2) receptor can exacerbate inflammatory bowel disease (IBD) through elimination of…”
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Characterization of the Natural Killer T-Cell Response in an Adoptive Transfer Model of Atherosclerosis by VanderLaan, Paul A, Reardon, Catherine A, Sagiv, Yuval, Blachowicz, Lydia, Lukens, John, Nissenbaum, Michael, Wang, Chyung-Ru, Getz, Godfrey S

“…Natural killer T (NKT) cells have recently been implicated in atherogenesis, primarily for their ability to recognize and respond to lipid antigens. Because…”
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Lysosomal recycling terminates CD1d-mediated presentation of short and polyunsaturated variants of the NKT cell lipid antigen [alpha]GalCer by Bai, Li, Sagiv, Yuval, Liu, Yang, Freigang, Stefan, Yu, Karl O A, Teyton, Luc, Porcelli, Steven A, Savage, Paul B, Bendelac, Albert

“…Short or polyunsaturated lipid variants of the NKT cell antigen α-galactosylceramide (αGC) exhibit decreased potency and a Th2 bias in vivo despite conserved…”
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A distal effect of microsomal triglyceride transfer protein deficiency on the lysosomal recycling of CD1d by Sagiv, Yuval, Bai, Li, Wei, Datsen G., Agami, Reuven, Savage, Paul B., Teyton, Luc, Bendelac, Albert

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