Search Results - "Sagineedu, Sreenivasa Rao"

Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function by Hocker, Harrison J, Cho, Kwang-Jin, Chen, Chung-Ying K, Rambahal, Nandini, Sagineedu, Sreenivasa Rao, Shaari, Khozirah, Stanslas, Johnson, Hancock, John F, Gorfe, Alemayehu A

“…Aberrant signaling by oncogenic mutant rat sarcoma (Ras) proteins occurs in ∼15% of all human tumors, yet direct inhibition of Ras by small molecules has…”
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Pharmacological Modulation of Apoptosis and Autophagy in Pancreatic Cancer Treatment by Selvarajoo, Nityaa, Stanslas, Johnson, Islam, Mohammad Kaisarul, Sagineedu, Sreenivasa Rao, Lian, Ho Kok, Lim, Jonathan Chee Woei

“…Pancreatic cancer is a fatal malignant neoplasm with infrequent signs and symptoms until a progressive stage. In 2020, GLOBOCAN reported that pancreatic cancer…”
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The impact of cycleanine in cancer research: a computational study by Nwaefulu, Ogochukwu Ngozi, Al-Shar’i, Nizar A., Owolabi, Josephine Omonkhelin, Sagineedu, Sreenivasa Rao, Woei, Lim Chee, Wai, Lam Kok, Islam, Mohammad Kaisarul, Jayanthi, Sivaraman, Stanslas, Johnson

“…Cancer is imposing a global health burden because of the steady increase in new cases. Moreover, current anticancer therapeutics are associated with many…”
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In silico and saturation transfer difference NMR approaches to unravel the binding mode of an andrographolide derivative to K-Ras oncoprotein by Quah, Shun Ying, Tan, Michelle Siying, Ho, Kok Lian, Manan, Nizar Abdul, Gorfe, Alemayehu Abebe, Deb, Pran Kishore, Sagineedu, Sreenivasa Rao, Stanslas, Johnson

“…Andrographolide and its benzylidene derivatives, SRJ09 and SRJ23, potentially bind oncogenic K-Ras to exert anticancer activity. Their molecular interactions…”
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A classical genetic solution to enhance the biosynthesis of anticancer phytochemicals in Andrographis paniculata Nees by Valdiani, Alireza, Talei, Daryush, Tan, Soon Guan, Abdul Kadir, Mihdzar, Maziah, Mahmood, Rafii, Mohd Yusop, Sagineedu, Sreenivasa Rao

“…Andrographolides, the diterpene lactones, are major bioactive phytochemicals which could be found in different parts of the medicinal herb Andrographis…”
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Edible foxtail millet flour stabilises and retain the in vitro activity of blueberry bioactive components by Mak, Kit‐Kay, Rathinasabapathy, Thirumurugan, Sankaran, Shanta, Kandasamy, Murugesh, Ling, Elaine Chan Wan, Balijepalli, Madhu Katyayani, Sagineedu, Sreenivasa Rao, Pichika, Mallikarjuna Rao

“…Summary Blueberries, a functional food, are rich in bioactive polyphenols and anthocyanins. However, the shelf life is short and requires cold storage. This…”
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In vitro 3D colon tumor penetrability of SRJ09, a new anti-cancer andrographolide analog by Wong, Charng Choon, Periasamy, Nagarajan, Sagineedu, Sreenivasa Rao, Sidik, Shiran, Sumon, Shariful Hasan, Loadman, Paul, Phillips, Roger, Lajis, Nordin Haji, Stanslas, Johnson

“…Summary Limited tumor penetrability of anti-cancer drugs is recognized as one of the major factors that lead to poor anti-tumor activity. SRJ09…”
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Advances and challenges in developing andrographolide and its analogues as cancer therapeutic agents by Soo, Hon Liong, Quah, Shun Ying, Sulaiman, Ibrahim, Sagineedu, Sreenivasa Rao, Lim, Jonathan Chee Woei, Stanslas, Johnson

“…•New semisynthetic molecules derived from AGP in recent years to target cancer have not been discussed in any review thus far.•With 20 years of research…”
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A K‐RAS Inhibitor Abrogates Self‐Renewal of Pancreatic Cancer Stem Cells via K‐RAS – NF‐κB – SOX2 Axis by Stanslas, Johnson, Teh, Yuan Han, Ho, Kok Lian, Ramasamy, Rajesh, Sagineedu, Sreenivasa Rao

“…Abstract only…”
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Microarray-based identification of differentially expressed genes associated with andrographolide derivatives-induced resistance in colon and prostate cancer cell lines by Quah, Shun Ying, Wong, Charng Choon, Wong, Hui Chyn, Ho, Kok Lian, Abdul Manan, Nizar, Deb, Pran Kishore, Sagineedu, Sreenivasa Rao, Stanslas, Johnson

“…Chemoresistance poses a major hurdle to cancer treatments. Andrographolide-derived SRJ09 and SRJ23 were reported to exhibit potent, selective inhibitory…”
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More than just a KRAS inhibitor: DCAI abrogates the self-renewal of pancreatic cancer stem cells in vitro by Teh, Yuan Han, Jing, Rui, Ramasamy, Rajesh, Ho, Kok Lian, Sagineedu, Sreenivasa Rao, Stanslas, Johnson

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SRS06, a new semisynthetic andrographolide derivative with improved anticancer potency and selectivity, inhibits nuclear factor-κB nuclear binding in the A549 non-small cell lung cancer cell line by Lim, Jonathan Chee Woei, Jeyaraj, Ethel Jeyaseela, Sagineedu, Sreenivasa Rao, Wong, Wai Shiu Fred, Stanslas, Johnson

“…Andrographolide has been reported with anticancer and anti-inflammatory properties through the inhibition of the activity of signaling molecules such as v-Src,…”
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Salt stress-induced protein pattern associated with photosynthetic parameters and andrographolide content in Andrographis paniculata Nees by Talei, Daryush, Valdiani, Alireza, Maziah, Mahmood, Sagineedu, Sreenivasa Rao, Abiri, Rambod

“…Andrographis paniculata is a multifunctional medicinal plant and a potent source of bioactive compounds. Impact of environmental stresses such as salinity on…”
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SRJ09, a promising anticancer drug lead: Elucidation of mechanisms of antiproliferative and apoptogenic effects and assessment of in vivo antitumor efficacy by Wong, Charng Choon, Lim, Siang Hui, Sagineedu, Sreenivasa Rao, Lajis, Nordin Haji, Stanslas, Johnson

“…[Display omitted] SRJ09 (3,19-(2-bromobenzylidene)andrographolide), a semisynthetic andrographolide (AGP) derivative, was shown to induce G1 cell cycle arrest…”
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Quantitative analysis of andrographolide, a biomarker of Andrographis paniculata, using qNMR spectroscopy by Sagineedu, Sreenivasa Rao, Kong, Ka Ling, Phang, Sze Ying, Toh, Boon Ling, Chu, Vun San, Hamzah, Ahmad Sazali, Stanslas, Johnson

“…Abstract only…”
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Quantitative analysis of andrographolide, a biomarker of Andrographis paniculata, using qNMR spectroscopy by Sagineedu, Sreenivasa Rao, Kong, Ka Ling, Phang, Sze Ying, Toh, Boon Ling, Chu, Vun San, Hamzah, Ahmad Sazali, Stanslas, Johnson

“…Abstract only…”
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Analysis of the Anticancer Phytochemicals in Andrographis paniculata Nees. under Salinity Stress by Sagineedu, Sreenivasa Rao, Mahmood, Maziah, Valdiani, Alireza, Talei, Daryush, Saad, Mohd Said

“…Salinity causes the adverse effects in all physiological processes of plants. The present study aimed to investigate the potential of salt stress to enhance…”
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Abstract 4454: SRJ09, a semisynthetic anticancer agent, targets Ras-MAPK signaling pathway: assessment in breast and colon cancer cell lines by Stanslas, Johnson, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sidik, Shiran Mohd, Sumon, Shariful Hasan, Phillips, Roger, Lajis, Nordin Haji

“…SRJ09 (3,19-(2-bromobenzylidene)andrographolide) was shown to be more selective towards breast and colon cancers in USA NCI 60 cancer cell line screen, thus…”
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NCI in vitro and in silico anticancer screen, cell cycle pertubation and apoptosis-inducing potential of new acylated, benzylidene and isopropylidene derivatives of andrographolide by Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Sumon, Shariful Hasan, Sidik, Shiran Mohamad, Phillips, Roger, Lajis, Nordin H, Stanslas, Johnson

“…Highlights • Andrographolide (AGP) has been shown to possess promising anticancer activity. • We evaluated the anticancer potential of newer AGP derivatives. •…”
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SRJ23, a new semisynthetic andrographolide derivative: in vitro growth inhibition and mechanisms of cell cycle arrest and apoptosis in prostate cancer cells by Wong, Hui Chyn, Wong, Charng Choon, Sagineedu, Sreenivasa Rao, Loke, Seng Cheong, Lajis, Nordin Haji, Stanslas, Johnson

“…Purpose 3,19-(3-Chloro-4-fluorobenzylidene)andrographolide (SRJ23), a new semisynthetic derivative of andrographolide (AGP), exhibited selectivity against…”
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