Search Results - "Sagi, Irit"

Next generation matrix metalloproteinase inhibitors — Novel strategies bring new prospects by Levin, Maxim, Udi, Yael, Solomonov, Inna, Sagi, Irit

“…Enzymatic proteolysis of cell surface proteins and extracellular matrix (ECM) is critical for tissue homeostasis and cell signaling. These proteolytic…”
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The ECM path of senescence in aging: components and modifiers by Levi, Naama, Papismadov, Nurit, Solomonov, Inna, Sagi, Irit, Krizhanovsky, Valery

“…The extracellular matrix (ECM) is a key noncellular component in all organs and tissues. It is composed of a large number of proteins including collagens,…”
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Phagocyte—extracellular matrix crosstalk empowers tumor development and dissemination by Varol, Chen, Sagi, Irit

“…Phagocytes, such as tumor‐associated macrophages (TAMs) and tumor‐associated neutrophils (TANs), are abundant in the stroma of experimental and human tumors…”
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The extracellular matrix protein agrin promotes heart regeneration in mice by Bassat, Elad, Mutlak, Yara Eid, Genzelinakh, Alex, Shadrin, Ilya Y., Baruch Umansky, Kfir, Yifa, Oren, Kain, David, Rajchman, Dana, Leach, John, Riabov Bassat, Daria, Udi, Yael, Sarig, Rachel, Sagi, Irit, Martin, James F., Bursac, Nenad, Cohen, Shenhav, Tzahor, Eldad

“…The adult mammalian heart is non-regenerative owing to the post-mitotic nature of cardiomyocytes. The neonatal mouse heart can regenerate, but only during the…”
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Tumor macrophages are pivotal constructors of tumor collagenous matrix by Afik, Ran, Zigmond, Ehud, Vugman, Milena, Klepfish, Mordehay, Shimshoni, Elee, Pasmanik-Chor, Metsada, Shenoy, Anjana, Bassat, Elad, Halpern, Zamir, Geiger, Tamar, Sagi, Irit, Varol, Chen

“…Tumor-associated macrophages (TAMs) promote tumor development, invasion, and dissemination by various mechanisms. In this study, using an orthotopic colorectal…”
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Detection of isolated protein-bound metal ions by single-particle cryo-STEM by Elad, Nadav, Bellapadrona, Giuliano, Houben, Lothar, Sagi, Irit, Elbaum, Michael

“…Metal ions play essential roles in many aspects of biological chemistry. Detecting their presence and location in proteins and cells is important for…”
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The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery by Afratis, Nikolaos A., Klepfish, Mordehay, Karamanos, Nikos K., Sagi, Irit

“…Progressive loss of organ function in most organs is associated with fibrosis, a tissue state associated with abnormal matrix buildup. If highly progressive,…”
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The glial scar-monocyte interplay: a pivotal resolution phase in spinal cord repair by Shechter, Ravid, Raposo, Catarina, London, Anat, Sagi, Irit, Schwartz, Michal

“…The inflammatory response in the injured spinal cord, an immune privileged site, has been mainly associated with the poor prognosis. However, recent data…”
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Correlated structural kinetics and retarded solvent dynamics at the metalloprotease active site by Sagi, Irit, Havenith, Martina, Grossman, Moran, Born, Benjamin, Heyden, Matthias, Tworowski, Dmitry, Fields, Gregg B

“…Solvent dynamics are an often overlooked component in enzymatic activity. Terahertz spectroscopy, X-ray absorption analysis and molecular dynamics simulations…”
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Persistent Chemiluminescent Glow of Phenoxy‐dioxetane Luminophore Enables Unique CRET‐Based Detection of Proteases by Hananya, Nir, Press, Ofir, Das, Alakesh, Scomparin, Anna, Satchi‐Fainaro, Ronit, Sagi, Irit, Shabat, Doron

“…Chemiluminescence is being considered an effective imaging modality as it offers low background and high sensitivity. Recent discovery by our group has led to…”
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PAR1 signaling regulates the retention and recruitment of EPCR-expressing bone marrow hematopoietic stem cells by Gur-Cohen, Shiri, Itkin, Tomer, Chakrabarty, Sagarika, Graf, Claudine, Kollet, Orit, Ludin, Aya, Golan, Karin, Kalinkovich, Alexander, Ledergor, Guy, Wong, Eitan, Niemeyer, Elisabeth, Porat, Ziv, Erez, Ayelet, Sagi, Irit, Esmon, Charles T, Ruf, Wolfram, Lapidot, Tsvee

“…Factors traditionally associated with coagulation and inflammation, such as thrombin, PAR1, aPC and EPCR, also independently control the nitric oxide…”
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Daily Onset of Light and Darkness Differentially Controls Hematopoietic Stem Cell Differentiation and Maintenance by Golan, Karin, Kumari, Anju, Kollet, Orit, Khatib-Massalha, Eman, Subramaniam, Mohana Devi, Ferreira, Zulma S., Avemaria, Francesca, Rzeszotek, Sylwia, García-García, Andrés, Xie, Stephanie, Flores-Figueroa, Eugenia, Gur-Cohen, Shiri, Itkin, Tomer, Ludin-Tal, Aya, Massalha, Hassan, Bernshtein, Biana, Ciechanowicz, Andrzej K., Brandis, Alexander, Mehlman, Tevie, Bhattacharya, Suditi, Bertagna, Mayla, Cheng, Hui, Petrovich-Kopitman, Ekaterina, Janus, Tomasz, Kaushansky, Nathali, Cheng, Tao, Sagi, Irit, Ratajczak, Mariusz Z., Méndez-Ferrer, Simón, Dick, John E., Markus, Regina P., Lapidot, Tsvee

“…Hematopoietic stem and progenitor cells (HSPCs) tightly couple maintenance of the bone marrow (BM) reservoir, including undifferentiated long-term repopulating…”
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Transformation mechanism of amorphous calcium carbonate into calcite in the sea urchin larval spicule by Politi, Yael, Metzler, Rebecca A, Abrecht, Mike, Gilbert, Benjamin, Wilt, Fred H, Sagi, Irit, Addadi, Lia, Weiner, Steve, Gilbert, Pupa

“…Sea urchin larval spicules transform amorphous calcium carbonate (ACC) into calcite single crystals. The mechanism of transformation is enigmatic: the…”
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Blocking Surgically Induced Lysyl Oxidase Activity Reduces the Risk of Lung Metastases by Rachman-Tzemah, Chen, Zaffryar-Eilot, Shelly, Grossman, Moran, Ribero, Dario, Timaner, Michael, Mäki, Joni M., Myllyharju, Johanna, Bertolini, Francesco, Hershkovitz, Dov, Sagi, Irit, Hasson, Peleg, Shaked, Yuval

“…Surgery remains the most successful curative treatment for cancer. However, some patients with early-stage disease who undergo surgery eventually succumb to…”
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The ADAM17 protease promotes tobacco smoke carcinogen-induced lung tumorigenesis by Saad, Mohamed I, McLeod, Louise, Yu, Liang, Ebi, Hiromichi, Ruwanpura, Saleela, Sagi, Irit, Rose-John, Stefan, Jenkins, Brendan J

“…Abstract Lung cancer is the leading cause of cancer-related mortality, with most cases attributed to tobacco smoking, in which nicotine-derived nitrosamine…”
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Role of Magnesium Ion in the Stabilization of Biogenic Amorphous Calcium Carbonate: A Structure−Function Investigation by Politi, Yael, Batchelor, David R, Zaslansky, Paul, Chmelka, Bradley F, Weaver, James C, Sagi, Irit, Weiner, Steve, Addadi, Lia

“…Magnesium is a key component used by many organisms in biomineralization. One role for magnesium is in stabilizing an otherwise unstable amorphous calcium…”
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LOXL2 Inhibition Paves the Way for Macrophage-Mediated Collagen Degradation in Liver Fibrosis by Klepfish, Mordehay, Gross, Tamar, Vugman, Milena, Afratis, Nikolaos A, Havusha-Laufer, Sapir, Brazowski, Eli, Solomonov, Inna, Varol, Chen, Sagi, Irit

“…Liver fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) proteins and enzymes, especially fibrillary collagens, and…”
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Cardiac remodeling secondary to chronic volume overload is attenuated by a novel MMP9/2 blocking antibody by Cohen, Lena, Sagi, Irit, Bigelman, Einat, Solomonov, Inna, Aloshin, Anna, Ben-Shoshan, Jeremy, Rozenbaum, Zach, Keren, Gad, Entin-Meer, Michal

“…Monoclonal antibody derivatives are promising drugs for the treatment of various diseases due to their high matrix metalloproteinases (MMP) active site…”
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Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential by Sela-Passwell, Netta, Kikkeri, Raghavendra, Dym, Orly, Rozenberg, Haim, Margalit, Raanan, Arad-Yellin, Rina, Eisenstein, Miriam, Brenner, Ori, Shoham, Tsipi, Danon, Tamar, Shanzer, Abraham, Sagi, Irit

“…By immunizing mice with a small synthetic metal-baring complex mimicking the active site of matrix metalloproteinases (MMPs), the authors have generated…”
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ADAM17 selectively activates the IL‐6 trans‐signaling/ERK MAPK axis in KRAS‐addicted lung cancer by Saad, Mohamed I, Alhayyani, Sultan, McLeod, Louise, Yu, Liang, Alanazi, Mohammad, Deswaerte, Virginie, Tang, Ke, Jarde, Thierry, Smith, Julian A, Prodanovic, Zdenka, Tate, Michelle D, Balic, Jesse J, Watkins, D Neil, Cain, Jason E, Bozinovski, Steven, Algar, Elizabeth, Kohmoto, Tomohiro, Ebi, Hiromichi, Ferlin, Walter, Garbers, Christoph, Ruwanpura, Saleela, Sagi, Irit, Rose‐John, Stefan, Jenkins, Brendan J

“…Oncogenic KRAS mutations are major drivers of lung adenocarcinoma (LAC), yet the direct therapeutic targeting of KRAS has been problematic. Here, we reveal an…”
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