Alteration in Gut Microbiota Composition of Older Adults Is Associated with Obesity and Its Indices: A Systematic Review

Alteration in Gut Microbiota Composition of Older Adults Is Associated with Obesity and Its Indices: A Systematic Review

Background Obesity in the older adults is a health concern that increases the risk of several life-threatening diseases. Previous research has been revealed that alterations in the gut microbiota composition is related to obesity. So, understanding the gut microbiota changes in older adults’ obesity...

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Bibliographic Details
Published in:The Journal of nutrition, health & aging Vol. 27; no. 10; pp. 817 - 823
Main Authors: Tavassol, Z. Hoseini, Ejtahed, H.-S., Atlasi, R., Saghafian, F., Khalagi, K., Hasani-Ranjbar, Shirin, Siadat, S. D., Nabipour, I., Ostovar, A., Larijani, B.
Format: Journal Article
Language:English
Published: Paris Springer Paris 01-10-2023
Springer Nature B.V
Subjects:
Aged
Aging
Diabetes Mellitus
Gastrointestinal Microbiome
Geriatrics/Gerontology
Humans
Medicine & Public Health
Metabolic Syndrome
Microbiota
Neurosciences
Nutrition
Obesity
Obesity - complications
Older people
Primary Care Medicine
Quality of Life Research
Review
Systematic review
Gut microbiota
elderly
obesity
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Summary:Background Obesity in the older adults is a health concern that increases the risk of several life-threatening diseases. Previous research has been revealed that alterations in the gut microbiota composition is related to obesity. So, understanding the gut microbiota changes in older adults’ obesity may help to provide promising strategies for their health management. Objectives Here we conducted a systematic review that investigate the alteration of gut microbiota composition in association with obesity and its indices in the older adults. Design Systematic review. Setting A comprehensive systematic search was performed through PubMed, Web of Science, Scopus and Embase databases for all relative studies up to 2023 with the main search concepts as Microbiota, Obesity and Elderly. The data about gut microbiota in association with obesity indices had been extracted. Participants Older adults (≥60 years). Intervention None. Measurements None. Results Within 10741 recordes, 11 studies met the inclusion criteria and were included in this systematic review. Most of them indicated the gut microbiota alterations in obese compared with non-obese older adults. However, the gut microbiome composition in obese older adults is affected by other underlying diseases like diabetes and metabolic syndrome. The most important taxa that had abundance alteration in association with obesity in older adults were Christensenellaceae, Porphyromonadaceae and Rikenellaceae, Akkermansia, Blautia, Prevotella, Ruminococcus, Bacteroides and Faecalibacterium. Conclusion The gut microbiota composition is associated with obesity in older adults. Considering the other factors affecting the composition of gut microbiota, such as age, underlying diseases and lifestyle, a more accurate conclusion about this matter requires more future studies.
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ISSN:1279-7707
1760-4788
DOI:10.1007/s12603-023-1988-8