Search Results - "Sager, Thomas Nikolaj"

Nest building performance following MPTP toxicity in mice by Sager, Thomas Nikolaj, Kirchhoff, Jeppe, Mørk, Arne, Van Beek, Johan, Thirstrup, Kenneth, Didriksen, Michael, Lauridsen, Jes Brix

“…Systemic injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mice is one of the primary models used to evaluate neuroprotective and symptomatic…”
Get full text

HIF prolyl hydroxylase inhibition increases cell viability and potentiates dopamine release in dopaminergic cells by Johansen, Jens Leander, Sager, Thomas Nikolaj, Lotharius, Julie, Witten, Louise, Mørk, Arne, Egebjerg, Jan, Thirstrup, Kenneth

“…J. Neurochem. (2010) 115, 209-219. Hypoxia-inducible factor (HIF) controls the expression of genes that adapts the cellular condition to accommodate oxidative…”
Get full text

Competitive HIF Prolyl Hydroxylase Inhibitors Show Protection against Oxidative Stress by a Mechanism Partially Dependent on Glycolysis by Bergström, Ann-Louise, Fog, Karina, Sager, Thomas Nikolaj, Bruun, Anne Techau, Thirstrup, Kenneth

“…The hypoxia inducible factor 1 (HIF-1) is a central transcription factor involved in the cellular and molecular adaptation to hypoxia and low glucose supply…”
Get full text

Astroglia Contain a Specific Transport Mechanism for N‐Acetyl‐l‐Aspartate by Sager, Thomas Nikolaj, Thomsen, Christian, Valsborg, Jacob Stenmann, Laursen, Henning, Hansen, Anker Jon

“…: N‐Acetylaspartate (NAA) is the second most abundant amino acid in the adult brain. It is located and synthesized in neurons and probably degraded in the glia…”
Get full text

Endogenous 2-oxoglutarate levels impact potencies of competitive HIF prolyl hydroxylase inhibitors by Thirstrup, Kenneth, Christensen, Søren, Møller, Henriette Aaris, Ritzén, Andreas, Bergström, Ann-Louise, Sager, Thomas Nikolaj, Jensen, Henrik Sindal

“…The stability and transcriptional activity of the hypoxia-inducible factors (HIFs) are regulated by oxygen-dependent hydroxylation that is catalyzed by three…”
Get full text

Synthesis and Preliminary Biological Evaluation of 2′-Substituted 2-(3′-Carboxybicyclo[1.1.1]pentyl)glycine Derivatives as Group I Selective Metabotropic Glutamate Receptor Ligands by Pellicciari, Roberto, Filosa, Rosanna, Fulco, Maria Carmela, Marinozzi, Maura, Macchiarulo, Antonio, Novak, Clemens, Natalini, Benedetto, Hermit, Mette Brunsgaard, Nielsen, Søren, Sager, Thomas Nikolaj, Stensbøl, Tine Bryan, Thomsen, Christian

“…The first series of 2′‐substituted 2‐(3′‐carboxybicyclo[1.1.1]pentyl)glycine derivatives, (2R)‐ and (2S)‐(2′,2′‐dichloro‐3′‐carboxybicyclo[1.1.1]pentyl)glycine…”
Get full text

Transient Elevation of Interstitial N‐Acetylaspartate in Reversible Global Brain Ischemia by Sager, Thomas Nikolaj, Fink‐Jensen, Anders, Hansen, Ander Jon

“…: We evaluated the changes of interstitial N‐acetylaspartate (NAA) concentration ([NAA]e) in rat striatum by microdialysis following transient global ischemia…”
Get full text

Changes in N-acetyl-aspartate content during focal and global brain ischemia of the rat by Sager, T N, Laursen, H, Hansen, A J

“…N-Acetyl-aspartate (NAA) is almost exclusively localized in neurons in the mature brain and might be used as a neuronal marker. It has been reported that the…”
Get more information

N-Acetylaspartate Distribution in Rat Brain Striatum During Acute Brain Ischemia by Sager, Thomas Nikolaj, Laursen, Henning, Fink-Jensen, Anders, Topp, Simon, Stensgaard, Anders, Hedehus, Maj, Rosenbaum, Sverre, Valsborg, Jacob Stenmann, Hansen, Anker Jon

“…Brain N-acetylaspartate (NAA) can be quantified by in vivo proton magnetic resonance spectroscopy (1H-MRS) and is used in clinical settings as a marker of…”
Get full text