Search Results - "Sager, Thomas N."

Effects of posttraumatic carbamylated erythropoietin therapy on reducing lesion volume and hippocampal cell loss, enhancing angiogenesis and neurogenesis, and improving functional outcome in rats following traumatic brain injury by YE XIONG, MAHMOOD, Asim, YANLU ZHANG, YULING MENG, ZHENG GANG ZHANG, CHANGSHENG QU, SAGER, Thomas N, CHOPP, Michael

“…Carbamylated erythropoietin (CEPO) is a modified erythropoietin molecule that does not affect hematocrit. In this study, the authors compared the efficacy of a…”
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Effects of acute and chronic aripiprazole treatment on choice between cocaine self-administration and food under a concurrent schedule of reinforcement in rats by Thomsen, Morgane, Fink-Jensen, Anders, Woldbye, David P. D., Wörtwein, Gitta, Sager, Thomas N., Holm, Rene, Pepe, Lauren M., Barak Caine, S.

“…Rationale Dopamine D2-like partial agonists such as aripiprazole have received some attention as potential pharmacotherapies for the treatment of…”
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A Subpopulation of Neuronal M4 Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors by Jeon, Jongrye, Dencker, Ditte, Wortwein, Gitta, Woldbye, David P. D, Cui, Yinghong, Davis, Albert A, Levey, Allan I, Schutz, Gunther, Sager, Thomas N, Mork, Arne, Li, Cuiling, Deng, Chu-Xia, Fink-Jensen, Anders, Wess, Jurgen

“…Acetylcholine (ACh) regulates many key functions of the CNS by activating cell surface receptors referred to as muscarinic ACh receptors (M(1)-M(5) mAChRs)…”
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Differential actions of adenosine A1 and A2A antagonists on the effort-related effects of dopamine D2 antagonism by SALAMONE, John D, FARRAR, Andrew M, FONT, Laura, PATEL, Vatsal, SCHLAR, Devra E, NUNES, Eric J, COLLINS, Lyndsey E, SAGER, Thomas N

“…Adenosine and dopamine receptors in striatal areas interact to regulate a number of different functions, including aspects of motor control and motivation…”
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Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline by Dencker, Ditte, Wörtwein, Gitta, Weikop, Pia, Jeon, Jongrye, Thomsen, Morgane, Sager, Thomas N, Mørk, Arne, Woldbye, David P D, Wess, Jürgen, Fink-Jensen, Anders

“…Disturbances in central dopaminergic neurotransmission are believed to be centrally involved in the pathogenesis of schizophrenia. Central dopaminergic and…”
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Tumor Necrosis Factor α Primes Cerebral Endothelial Cells for Erythropoietin-Induced Angiogenesis by Wang, Lei, Chopp, Michael, Teng, Hua, Bolz, Marianne, Francisco, Moniche Ãlvarez, Aluigi, Danielle Marie, Wang, Xin Li, Zhang, Rui Lan, Chrsitensen, Søren, Sager, Thomas N, Szalad, Alexandra, Zhang, Zheng Gang

“…Erythropoietin (EPO) enhances angiogenesis in the ischemic brain. Stroke induces secretion of tumor necrosis factor α (TNF-α). We investigated the effect of…”
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Correlation between N-Acetylaspartate Levels and Histopathologic Changes in Cortical Infarcts of Mice after Middle Cerebral Artery Occlusion by Sager, Thomas N., Hansen, Anker J., Laursen, Henning

“…The aim of the present study was to evaluate the use of the endogenous neuronal compound N-acetylaspartate (NAA) as a marker of neuronal damage after focal…”
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Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective A2A and A1 antagonists by Randall, Patrick A., Nunes, Eric J., Janniere, Simone L., Stopper, Colin M., Farrar, Andrew M., Sager, Thomas N., Baqi, Younis, Hockemeyer, Jörg, Müller, Christa E., Salamone, John D.

“…Rationale Adenosine A 2A antagonists can reverse many of the behavioral effects of dopamine antagonists, including actions on instrumental behavior. However,…”
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Stimulant effects of adenosine antagonists on operant behavior: differential actions of selective [A.sub.2A] and [A.sub.1] antagonists by Randall, Patrick A, Nunes, Eric J, Janniere, Simone L, Stopper, Colin M, Farrar, Andrew M, Sager, Thomas N, Baqi, Younis, Hockemeyer, Jorg, Muller, Christa E, Salamone, John D

“…Rationale Adenosine [A.sub.2A] antagonists can reverse many of the behavioral effects of dopamine antagonists, including actions on instrumental behavior…”
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Effects of postnatal anoxia on striatal dopamine metabolism and prepulse inhibition in rats by Sandager-Nielsen, Karin, Andersen, Maibritt B, Sager, Thomas N, Werge, Thomas, Scheel-Krüger, Jørgen

“…Various evidence indicate that schizophrenia is a neurodevelopmental disorder. Epidemiological observations point to oxygen deficiencies during delivery as one…”
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Tremorolytic effects of adenosine A2A antagonists: implications for parkinsonism by Salamone, John D, Betz, Adrienne J, Ishiwari, Keita, Felsted, Jennifer, Madson, Lisa, Mirante, Brian, Clark, Karen, Font, Laura, Korbey, Samantha, Sager, Thomas N, Hockemeyer, Jorg, Muller, Christa E

“…Drug-induced tremulous jaw movements in rats have been used as a model of parkinsonian tremor. Because adenosine A2A antagonists have antiparkinsonian effects,…”
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Oral tremor induced by the muscarinic agonist pilocarpine is suppressed by the adenosine A2A antagonists MSX-3 and SCH58261, but not the adenosine A1 antagonist DPCPX by COLLINS, Lyndsey E, GALTIERI, Daniel J, BRENNUM, Lise T, SAGER, Thomas N, HOCKEMEYER, Jörg, MÜLLER, Christa E, HINMAN, James R, CHROBAK, James J, SALAMONE, John D

“…Tremulous jaw movements in rats, which can be induced by dopamine (DA) antagonists, DA depletion, and cholinomimetics, have served as a useful model for…”
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Therapeutic window for nonerythropoietic carbamylated-erythropoietin to improve motor function following multiple infarct ischemic strokes in New Zealand white rabbits by Lapchak, Paul A, Kirkeby, Agnete, Zivin, Justin A, Sager, Thomas N

“…Abstract Carbamylated erythropoietin (CEPO) is a novel neuroprotective agent that does not bind to the classical erythropoietin receptor or affect hematocrit…”
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Aripiprazole blocks acute self-administration of cocaine and is not self-administered in mice by Sørensen, Gunnar, Sager, Thomas N., Petersen, Jørgen H., Brennum, Lise T., Thøgersen, Peter, Hee Bengtsen, Cecilie, Thomsen, Morgane, Wörtwein, Gitta, Fink-Jensen, Anders, Woldbye, David P. D.

“…Rationale The novel antipsychotic aripiprazole in use for treatment of schizophrenia is a partial agonist at dopamine D 2 receptors with actions at a variety…”
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Striatal extracellular dopamine levels and behavioural reversal in MPTP-lesioned mice by Kirchhoff, Jeppe, Mørk, Arne, Brennum, Lise T, Sager, Thomas N

“…Intoxication induced by MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) in mice results in a significant loss of nigrostriatal dopamine (DA) neurons. This…”
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The novel adenosine A2A antagonist Lu AA47070 reverses the motor and motivational effects produced by dopamine D2 receptor blockade by Collins, Lyndsey E., Sager, Thomas N., Sams, Anette G., Pennarola, Adam, Port, Russell G., Shahriari, Mona, Salamone, John D.

“…Dopamine D2 and adenosine A2A receptors interact to regulate aspects of motor and motivational function, and it has been suggested that adenosine A2A…”
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Tumor Necrosis Factor α Primes Cerebral Endothelial Cells for Erythropoietin-Induced Angiogenesis by Wang, Lei, Chopp, Michael, Teng, Hua, Bolz, Marianne, Francisco, Moniche Ãlvarez, Aluigi, Danielle Marie, Wang, Xin Li, Zhang, Rui Lan, Chrsitensen, Søren, Sager, Thomas N, Szalad, Alexandra, Zhang, Zheng Gang

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Neuroprotective effect of 8-OH-DPAT in global cerebral ischemia assessed by stereological cell counting by Torup, Lars, Møller, Arne, Sager, Thomas N, Diemer, Nils H

“…The neuroprotective effect of the 5-HT 1A receptor agonist 8-hydroxy-2-(di- n-propylamino)tetralin (8-OH-DPAT) was tested in a 2-vessel occlusion model in…”
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A Subpopulation of Neuronal M 4 Muscarinic Acetylcholine Receptors Plays a Critical Role in Modulating Dopamine-Dependent Behaviors by Jeon, Jongrye, Dencker, Ditte, Wörtwein, Gitta, Woldbye, David P. D., Cui, Yinghong, Davis, Albert A., Levey, Allan I., Schütz, Günther, Sager, Thomas N., Mørk, Arne, Li, Cuiling, Deng, Chu-Xia, Fink-Jensen, Anders, Wess, Jürgen

“…Acetylcholine (ACh) regulates many key functions of the CNS by activating cell surface receptors referred to as muscarinic ACh receptors (M 1 –M 5 mAChRs)…”
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Evaluation of CA1 damage using single-voxel 1H-MRS and un-biased stereology: Can non-invasive measures of N-acetyl-asparate following global ischemia be used as a reliable measure of neuronal damage? by Sager, Thomas N., Topp, Simon, Torup, Lars, Hanson, Lars G., Egestad, Börje, Møller, Arne

“…Global brain ischemia provoked by transient occlusion of the carotid arteries (2VO) in gerbils results in a severe loss of neurons in the hippocampal CA1…”
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