Search Results - "Sager, Mark"

Microstructural white matter alterations in preclinical Alzheimer's disease detected using free water elimination diffusion tensor imaging by Hoy, Andrew R, Ly, Martina, Carlsson, Cynthia M, Okonkwo, Ozioma C, Zetterberg, Henrik, Blennow, Kaj, Sager, Mark A, Asthana, Sanjay, Johnson, Sterling C, Alexander, Andrew L, Bendlin, Barbara B

“…Brain changes associated with Alzheimer's disease (AD) begin decades before disease diagnosis. While β-amyloid plaques and neurofibrillary tangles are defining…”
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Poor sleep is associated with CSF biomarkers of amyloid pathology in cognitively normal adults by Sprecher, Kate E, Koscik, Rebecca L, Carlsson, Cynthia M, Zetterberg, Henrik, Blennow, Kaj, Okonkwo, Ozioma C, Sager, Mark A, Asthana, Sanjay, Johnson, Sterling C, Benca, Ruth M, Bendlin, Barbara B

“…OBJECTIVE:To determine the relationship between sleep quality and CSF markers of Alzheimer disease (AD) pathology in late midlife. METHODS:We investigated the…”
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Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle-Aged Adults at Risk for Alzheimer Disease by Willette, Auriel A, Bendlin, Barbara B, Starks, Erika J, Birdsill, Alex C, Johnson, Sterling C, Christian, Bradley T, Okonkwo, Ozioma C, La Rue, Asenath, Hermann, Bruce P, Koscik, Rebecca L, Jonaitis, Erin M, Sager, Mark A, Asthana, Sanjay

“…Converging evidence suggests that Alzheimer disease (AD) involves insulin signaling impairment. Patients with AD and individuals at risk for AD show reduced…”
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Amyloid burden is associated with self-reported sleep in nondemented late middle-aged adults by Sprecher, Kate E, Bendlin, Barbara B, Racine, Annie M, Okonkwo, Ozioma C, Christian, Bradley T, Koscik, Rebecca L, Sager, Mark A, Asthana, Sanjay, Johnson, Sterling C, Benca, Ruth M

“…Abstract Midlife may be an ideal window for intervention in Alzheimer's disease (AD). To determine whether sleep is associated with early signs of AD…”
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Regional white matter hyperintensities: aging, Alzheimer's disease risk, and cognitive function by Birdsill, Alex C, Koscik, Rebecca L, Jonaitis, Erin M, Johnson, Sterling C, Okonkwo, Ozioma C, Hermann, Bruce P, LaRue, Asenath, Sager, Mark A, Bendlin, Barbara B

“…Abstract White matter hyperintensities (WMH) of presumed vascular origin, as seen on T2-weighted fluid attenuated inversion recovery magnetic resonance…”
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Insulin resistance predicts brain amyloid deposition in late middle-aged adults by Willette, Auriel A, Johnson, Sterling C, Birdsill, Alex C, Sager, Mark A, Christian, Bradley, Baker, Laura D, Craft, Suzanne, Oh, Jennifer, Statz, Eric, Hermann, Bruce P, Jonaitis, Erin M, Koscik, Rebecca L, La Rue, Asenath, Asthana, Sanjay, Bendlin, Barbara B

“…Abstract Background Insulin resistance (IR) increases Alzheimer's disease (AD) risk. IR is related to greater amyloid burden post-mortem and increased…”
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Early identification and treatment of Alzheimer's disease: Social and fiscal outcomes by Weimer, David L, Sager, Mark A

“…Abstract Background Alzheimer's disease (AD) is a progressive neurodegenerative disease that places substantial burdens on those who provide support for family…”
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Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle―Aged Adults by WILLETTE, Auriel A, GUOFAN XU, JOHNSON, Sterling C, BIRDSILL, Alex C, JONAITIS, Erin M, SAGER, Mark A, HERMANN, Bruce P, LA RUE, Asenath, ASTHANA, Sanjay, BENDLIN, Barbara B

“…Insulin resistance dysregulates glucose uptake and other functions in brain areas affected by Alzheimer disease. Insulin resistance may play a role in…”
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Association of Amyloid Pathology With Myelin Alteration in Preclinical Alzheimer Disease by Dean, 3rd, Douglas C, Hurley, Samuel A, Kecskemeti, Steven R, O'Grady, J Patrick, Canda, Cristybelle, Davenport-Sis, Nancy J, Carlsson, Cynthia M, Zetterberg, Henrik, Blennow, Kaj, Asthana, Sanjay, Sager, Mark A, Johnson, Sterling C, Alexander, Andrew L, Bendlin, Barbara B

“…The accumulation of aggregated β-amyloid and tau proteins into plaques and tangles is a central feature of Alzheimer disease (AD). While plaque and tangle…”
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Amyloid burden and neural function in people at risk for Alzheimer's Disease by Johnson, Sterling C, Christian, Bradley T, Okonkwo, Ozioma C, Oh, Jennifer M, Harding, Sandra, Xu, Guofan, Hillmer, Ansel T, Wooten, Dustin W, Murali, Dhanabalan, Barnhart, Todd E, Hall, Lance T, Racine, Annie M, Klunk, William E, Mathis, Chester A, Bendlin, Barbara B, Gallagher, Catherine L, Carlsson, Cynthia M, Rowley, Howard A, Hermann, Bruce P, Dowling, N. Maritza, Asthana, Sanjay, Sager, Mark A

“…Abstract To determine the relationship between amyloid burden and neural function in healthy adults at risk for Alzheimer's Disease (AD), we used multimodal…”
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Physical activity attenuates age-related biomarker alterations in preclinical AD by Okonkwo, Ozioma C, Schultz, Stephanie A, Oh, Jennifer M, Larson, Jordan, Edwards, Dorothy, Cook, Dane, Koscik, Rebecca, Gallagher, Catherine L, Dowling, N.M, Carlsson, Cynthia M, Bendlin, Barbara B, LaRue, Asenath, Rowley, Howard A, Christian, Brad T, Asthana, Sanjay, Hermann, Bruce P, Johnson, Sterling C, Sager, Mark A

“…OBJECTIVE:To examine whether engagement in physical activity might favorably alter the age-dependent evolution of Alzheimer disease (AD)-related brain and…”
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The Wisconsin Registry for Alzheimer's Prevention: A review of findings and current directions by Johnson, Sterling C., Koscik, Rebecca L., Jonaitis, Erin M., Clark, Lindsay R., Mueller, Kimberly D., Berman, Sara E., Bendlin, Barbara B., Engelman, Corinne D., Okonkwo, Ozioma C., Hogan, Kirk J., Asthana, Sanjay, Carlsson, Cynthia M., Hermann, Bruce P., Sager, Mark A.

“…The Wisconsin Registry for Alzheimer's Prevention is a longitudinal observational cohort study enriched with persons with a parental history (PH) of probable…”
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Impact of sex and APOE ε4 on age-related cerebral perfusion trajectories in cognitively asymptomatic middle-aged and older adults: A longitudinal study by Wang, Rui, Oh, Jennifer M, Motovylyak, Alice, Ma, Yue, Sager, Mark A, Rowley, Howard A, Johnson, Kevin M, Gallagher, Catherine L, Carlsson, Cynthia M, Bendlin, Barbara B, Johnson, Sterling C, Asthana, Sanjay, Eisenmenger, Laura, Okonkwo, Ozioma C

“…Cerebral hypoperfusion is thought to contribute to cognitive decline in Alzheimer’s disease, but the natural trajectory of cerebral perfusion in cognitively…”
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Verbal Fluency and Early Memory Decline: Results from the Wisconsin Registry for Alzheimer's Prevention by Mueller, Kimberly Diggle, Koscik, Rebecca L, LaRue, Asenath, Clark, Lindsay R, Hermann, Bruce, Johnson, Sterling C, Sager, Mark A

“…This study examined the relationship between phonemic and semantic (category) verbal fluency and cognitive status in the Wisconsin Registry for Alzheimer's…”
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The effect of body mass index on global brain volume in middle-aged adults: a cross sectional study by Ward, Michael A, Carlsson, Cynthia M, Trivedi, Mehul A, Sager, Mark A, Johnson, Sterling C

“…Obesity causes or exacerbates a host of medical conditions, including cardiovascular, pulmonary, and endocrine diseases. Recently obesity in elderly women was…”
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Vascular, inflammatory, and metabolic factors associated with cognition in aging persons with chronic epilepsy by Hermann, Bruce P., Sager, Mark A., Koscik, Rebecca L., Young, Kate, Nakamura, Keith

“…Summary We examined cognition in aging persons with chronic epilepsy; characterized targeted vascular, inflammatory, and metabolic risk factors associated with…”
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CSF T-Tau/Aβ42 predicts white matter microstructure in healthy adults at risk for Alzheimer's disease by Bendlin, Barbara B, Carlsson, Cynthia M, Johnson, Sterling C, Zetterberg, Henrik, Blennow, Kaj, Willette, Auriel A, Okonkwo, Ozioma C, Sodhi, Aparna, Ries, Michele L, Birdsill, Alex C, Alexander, Andrew L, Rowley, Howard A, Puglielli, Luigi, Asthana, Sanjay, Sager, Mark A

“…Cerebrospinal fluid (CSF) biomarkers T-Tau and Aβ(42) are linked with Alzheimer's disease (AD), yet little is known about the relationship between CSF…”
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Latent Structure and Factorial Invariance of a Neuropsychological Test Battery for the Study of Preclinical Alzheimer's Disease by Dowling, N. Maritza, Hermann, Bruce, La Rue, Asenath, Sager, Mark A

“…Objective: To examine the latent structure of a test battery currently being used in a longitudinal study of asymptomatic middle-aged adults with a parental…”
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Pathway-Specific Polygenic Risk Scores as Predictors of Amyloid-β Deposition and Cognitive Function in a Sample at Increased Risk for Alzheimer's Disease by Darst, Burcu F, Koscik, Rebecca L, Racine, Annie M, Oh, Jennifer M, Krause, Rachel A, Carlsson, Cynthia M, Zetterberg, Henrik, Blennow, Kaj, Christian, Bradley T, Bendlin, Barbara B, Okonkwo, Ozioma C, Hogan, Kirk J, Hermann, Bruce P, Sager, Mark A, Asthana, Sanjay, Johnson, Sterling C, Engelman, Corinne D

“…Polygenic risk scores (PRSs) have been used to combine the effects of variants with small effects identified by genome-wide association studies. We explore the…”
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Age-Dependent Differences in Brain Tissue Microstructure Assessed with Neurite Orientation Dispersion and Density Imaging by Merluzzi, Andrew P, Dean, Douglas C, Adluru, Nagesh, Suryawanshi, Gaurav S, Okonkwo, Ozioma C, Oh, Jennifer M, Hermann, Bruce P, Sager, Mark A, Asthana, Sanjay, Zhang, Hui, Johnson, Sterling C, Alexander, Andrew L, Bendlin, Barbara B

“…Abstract Human aging is accompanied by progressive changes in executive function and memory, but the biological mechanisms underlying these phenomena are not…”
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