Search Results - "Sage, T."

PD-1 pathway in tolerance and autoimmunity by Francisco, Loise M, Sage, Peter T, Sharpe, Arlene H

“…Regulatory T cells (Tregs) and the PD-1: PD-ligand (PD-L) pathway are both critical to terminating immune responses. Elimination of either can result in the…”
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The Coinhibitory Receptor CTLA-4 Controls B Cell Responses by Modulating T Follicular Helper, T Follicular Regulatory, and T Regulatory Cells by Sage, Peter T., Paterson, Alison M., Lovitch, Scott B., Sharpe, Arlene H.

“…The receptor CTLA-4 has been implicated in controlling B cell responses, but the mechanisms by which CTLA-4 regulates antibody production are not known. Here…”
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Obesity Shapes Metabolism in the Tumor Microenvironment to Suppress Anti-Tumor Immunity by Ringel, Alison E., Drijvers, Jefte M., Baker, Gregory J., Catozzi, Alessia, García-Cañaveras, Juan C., Gassaway, Brandon M., Miller, Brian C., Juneja, Vikram R., Nguyen, Thao H., Joshi, Shakchhi, Yao, Cong-Hui, Yoon, Haejin, Sage, Peter T., LaFleur, Martin W., Trombley, Justin D., Jacobson, Connor A., Maliga, Zoltan, Gygi, Steven P., Sorger, Peter K., Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.

“…Obesity is a major cancer risk factor, but how differences in systemic metabolism change the tumor microenvironment (TME) and impact anti-tumor immunity is not…”
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Mitochondrial Biogenesis and Proteome Remodeling Promote One-Carbon Metabolism for T Cell Activation by Ron-Harel, Noga, Santos, Daniel, Ghergurovich, Jonathan M., Sage, Peter T., Reddy, Anita, Lovitch, Scott B., Dephoure, Noah, Satterstrom, F. Kyle, Sheffer, Michal, Spinelli, Jessica B., Gygi, Steven, Rabinowitz, Joshua D., Sharpe, Arlene H., Haigis, Marcia C.

“…Naive T cell stimulation activates anabolic metabolism to fuel the transition from quiescence to growth and proliferation. Here we show that naive CD4+ T cell…”
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Ultrasensitive Electrochemical Biomolecular Detection Using Nanostructured Microelectrodes by Sage, Andrew T, Besant, Justin D, Lam, Brian, Sargent, Edward H, Kelley, Shana O

“…Conspectus Electrochemical sensors have the potential to achieve sensitive, specific, and low-cost detection of biomoleculesa capability that is ever more…”
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Defective TFH Cell Function and Increased TFR Cells Contribute to Defective Antibody Production in Aging by Sage, Peter T., Tan, Catherine L., Freeman, Gordon J., Haigis, Marcia, Sharpe, Arlene H.

“…Defective antibody production in aging is broadly attributed to immunosenescence. However, the precise immunological mechanisms remain unclear. Here, we…”
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FoxP3 and Ezh2 regulate Tfr cell suppressive function and transcriptional program by Hou, Shenda, Clement, Rachel L, Diallo, Alos, Blazar, Bruce R, Rudensky, Alexander Y, Sharpe, Arlene H, Sage, Peter T

“…Follicular regulatory T (Tfr) cells are a regulatory T cell subset that controls antibody production by inhibiting T follicular helper (Tfh)-mediated help to B…”
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Yield of Surveillance Colonoscopy in Older Adults with a History of Polyps: A Systematic Review and Meta-Analysis by Williams, Gregory J., Hellerstedt, Sage T., Scudder, Paige N., Calderwood, Audrey H.

“…Background The benefit of surveillance colonoscopy in older adults is not well described. Aims To quantify the detection of colorectal cancer (CRC) and…”
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An Introduction to the Saccharomyces Genome Database (SGD) by Lang, Olivia W, Nash, Robert S, Hellerstedt, Sage T, Engel, Stacia R

“…The Saccharomyces Genome Database (SGD) is a well-established, key resource for researchers studying Saccharomyces cerevisiae. In addition to updating and…”
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A machine-learning approach to human ex vivo lung perfusion predicts transplantation outcomes and promotes organ utilization by Sage, Andrew T., Donahoe, Laura L., Shamandy, Alaa A., Mousavi, S. Hossein, Chao, Bonnie T., Zhou, Xuanzi, Valero, Jerome, Balachandran, Sharaniyaa, Ali, Aadil, Martinu, Tereza, Tomlinson, George, Del Sorbo, Lorenzo, Yeung, Jonathan C., Liu, Mingyao, Cypel, Marcelo, Wang, Bo, Keshavjee, Shaf

“…Ex vivo lung perfusion (EVLP) is a data-intensive platform used for the assessment of isolated lungs outside the body for transplantation; however, the…”
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Delivery of costimulatory blockade to lymph nodes promotes transplant acceptance in mice by Zhao, Jing, Jung, Sungwook, Li, Xiaofei, Li, Lushen, Kasinath, Vivek, Zhang, Hengcheng, Movahedi, Said N, Mardini, Ahmad, Sabiu, Gianmarco, Hwang, Yoonha, Saxena, Vikas, Song, Yang, Ma, Bing, Acton, Sophie E, Kim, Pilhan, Madsen, Joren C, Sage, Peter T, Tullius, Stefan G, Tsokos, George C, Bromberg, Jonathan S, Abdi, Reza

“…The lymph node (LN) is the primary site of alloimmunity activation and regulation during transplantation. Here, we investigated how fibroblastic reticular…”
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Stepwise differentiation of follicular helper T cells reveals distinct developmental and functional states by Podestà, Manuel A., Cavazzoni, Cecilia B., Hanson, Benjamin L., Bechu, Elsa D., Ralli, Garyfallia, Clement, Rachel L., Zhang, Hengcheng, Chandrakar, Pragya, Lee, Jeong-Mi, Reyes-Robles, Tamara, Abdi, Reza, Diallo, Alos, Sen, Debattama R., Sage, Peter T.

“…Follicular helper T (Tfh) cells are essential for the formation of high affinity antibodies after vaccination or infection. Although the signals responsible…”
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Benefits of implementing student-led review and mock examinations in the medical undergraduate gross anatomy curriculum by Khatskevich, Katsiaryna, Hewitt, Sage T., Jang, Chang-Woo, Lewis, Nicholas, Liu, Langfeier, McGlawn-McGrane, Britton W., Bharadwaj, Srinivas Nagaraj, Mhaskar, Rahul

“…Anatomy consists of material that continually defines a student's undergraduate medical curriculum, and thus attaining a solid understanding of it is critical…”
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Recent Metabolic Advances for Preventing and Treating Acute and Chronic Graft Versus Host Disease by Mohamed, Fathima A, Thangavelu, Govindarajan, Rhee, Stephanie Y, Sage, Peter T, O'Connor, Roddy S, Rathmell, Jeffrey C, Blazar, Bruce R

“…The therapeutic efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is limited by the development of graft-versus-host disease (GVHD)…”
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Saccharomyces genome database informs human biology by Skrzypek, Marek S, Nash, Robert S, Wong, Edith D, MacPherson, Kevin A, Hellerstedt, Sage T, Engel, Stacia R, Karra, Kalpana, Weng, Shuai, Sheppard, Travis K, Binkley, Gail, Simison, Matt, Miyasato, Stuart R, Cherry, J Michael

“…Abstract The Saccharomyces Genome Database (SGD; http://www.yeastgenome.org) is an expertly curated database of literature-derived functional information for…”
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Osteomyelitis is associated with increased anti-inflammatory response and immune exhaustion by Surendar, Jayagopi, Hackenberg, Roslind K, Schmitt-Sánchez, Fabio, Ossendorff, Robert, Welle, Kristian, Stoffel-Wagner, Birgit, Sage, Peter T, Burger, Christof, Wirtz, Dieter C, Strauss, Andreas C, Schildberg, Frank A

“…Osteomyelitis (OMS) is a bone infection causing bone pain and severe complications. A balanced immune response is critical to eradicate infection without…”
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Future innovations in anti‐platelet therapies by Barrett, N E, Holbrook, L, Jones, S, Kaiser, W J, Moraes, L A, Rana, R, Sage, T, Stanley, R G, Tucker, K L, Wright, B, Gibbins, J M

“…Platelets have long been recognized to be of central importance in haemostasis, but their participation in pathological conditions such as thrombosis,…”
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Settings and mechanisms for trans-cellular diapedesis by Sage, Peter T, Carman, Christopher V

“…Immune system functions require blood leukocytes to continuously traffic throughout the body and repeatedly cross endothelial barriers (i.e., diapedese) as…”
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Utility of bile acids in large airway bronchial wash versus bronchoalveolar lavage as biomarkers of microaspiration in lung transplant recipients: a retrospective cohort study by Zhang, Chen Yang Kevin, Ahmed, Musawir, Huszti, Ella, Levy, Liran, Hunter, Sarah E., Boonstra, Kristen M., Moshkelgosha, Sajad, Sage, Andrew T., Azad, Sassan, Ghany, Rasheed, Yeung, Jonathan C., Crespin, Oscar M., Singer, Lianne G., Keshavjee, Shaf, Martinu, Tereza

“…Abstract Background Bronchoalveolar lavage (BAL) is a key tool in respiratory medicine for sampling the distal airways. BAL bile acids are putative biomarkers…”
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Regulation of Alloantibody Responses by Chong, Anita S, Sage, Peter T, Alegre, Maria-Luisa

“…The control of alloimmunity is essential to the success of organ transplantation. Upon alloantigen encounter, naïve alloreactive T cells not only differentiate…”
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