Search Results - "Sagawa, K."
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Safety and immunogenicity of a thermostable ID93 + GLA-SE tuberculosis vaccine candidate in healthy adults
Published in Nature communications (06-03-2023)“…Adjuvant-containing subunit vaccines represent a promising approach for protection against tuberculosis (TB), but current candidates require refrigerated…”
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Overcoming Barriers to Supply Chain Integration: Prioritization of Solutions via a Multicriteria Decision Support Method
Published in IEEE access (2024)“…Supply Chain Integration (SCI) has an important role in influencing supply chain overall performance. Although scholars and practitioners have identified…”
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Co-regulation of innate and adaptive immune responses induced by ID93+GLA-SE vaccination in humans
Published in Frontiers in immunology (24-09-2024)“…Development of an effective vaccine against tuberculosis is a critical step towards reducing the global burden of disease. A therapeutic vaccine might also…”
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Effects of chronic exposure to cocaine are regulated by the neuronal protein Cdk5
Published in Nature (London) (15-03-2001)“…Cocaine enhances dopamine-mediated neurotransmission by blocking dopamine re-uptake at axon terminals. Most dopamine-containing nerve terminals innervate…”
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Achievement of precise assembly of the JT-60SA superconducting tokamak
Published in Fusion engineering and design (01-01-2022)“…•We have achieved important mile stone for this project at the end of March 2020 taking about seven years since 2013. Namely, the tokamak main assembly has…”
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Characterization of CD4+ T helper cells in patients with Kawasaki disease (KD): preferential production of tumour necrosis factor‐alpha (TNF‐α) by Vβ2− or Vβ8− CD4+ T helper cells
Published in Clinical and experimental immunology (28-06-2008)“…SUMMARY KD is an acute febrile illness in children characterized by coronary arteritis accompanied by aneurysm and thrombotic occlusion. The etiology of KD is…”
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Expression of CD44 variant isoforms, CD44v3 and CD44v6, are associated with prognosis in nasopharyngeal carcinoma
Published in Journal of laryngology and otology (01-09-2016)“…The clinical and prognostic significance of CD44 variant isoform expression in nasopharyngeal carcinoma is not well known. This study aimed to clarify whether…”
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Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue
Published in Diabetes (New York, N.Y.) (01-05-2008)“…Monocyte Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue Elizabeth A. Kirk 1 2 , Zachary K. Sagawa 3 ,…”
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Hypothyroidism After Radiation Therapy for Head-and-Neck Cancer: The Retrospective DVH Analysis of 75 Patients -- Volume of Thyroid Gland Spared From Doses Can Be a New Dose Constraint for Treatment Planning?
Published in International journal of radiation oncology, biology, physics (01-11-2012)Get full text
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Toward the use of bond graphs for manufacturing control: comparison of existing models
Published in International journal of advanced manufacturing technology (01-07-2022)“…Companies compete in a fierce market, in which the main focus is consumer satisfaction, forcing them to respond dynamically to market changes and…”
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Consecutive national surveys of ABO-incompatible blood transfusion in Japan
Published in Vox sanguinis (01-10-2009)“…Background and Objectives Morbidity and mortality from ABO‐incompatible transfusion persist as consequences of human error. Even so, insufficient attention…”
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The end-systolic pressure-volume relation of the ventricle: definition, modifications and clinical use
Published in Circulation (New York, N.Y.) (01-06-1981)Get full text
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A phase 1 antigen dose escalation trial to evaluate safety, tolerability and immunogenicity of the leprosy vaccine candidate LepVax (LEP-F1 + GLA–SE) in healthy adults
Published in Vaccine (11-02-2020)“…•First in human evaluaiton of a defined subunit vaccine for leprosy.•LepVax (LEP-F1 + GLA-SE) demonstrated to be safe.•Comprable immune responses induced by 2…”
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The TLR-4 agonist adjuvant, GLA-SE, improves magnitude and quality of immune responses elicited by the ID93 tuberculosis vaccine: first-in-human trial
Published in npj vaccines (04-09-2018)“…Tuberculosis (TB) is the leading cause of infectious death worldwide. Development of improved TB vaccines that boost or replace BCG is a major global health…”
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Safety and immunogenicity of the adjunct therapeutic vaccine ID93 + GLA-SE in adults who have completed treatment for tuberculosis: a randomised, double-blind, placebo-controlled, phase 2a trial
Published in The lancet respiratory medicine (01-04-2021)“…A therapeutic vaccine that prevents recurrent tuberculosis would be a major advance in the development of shorter treatment regimens. We aimed to assess the…”
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Use of 3M-052-AF with Alum adjuvant in HIV trimer vaccine induces human autologous neutralizing antibodies
Published in The Journal of experimental medicine (07-10-2024)“…Stabilized trimers preserving the native-like HIV envelope structure may be key components of a preventive HIV vaccine regimen to induce broadly neutralizing…”
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Immunohistochemical staining of cutaneous tumours with G-81, a monoclonal antibody to dermcidin
Published in British journal of dermatology (1951) (01-07-2004)“…Summary Background Recently, the novel antimicrobial peptide named dermcidin (DCD) was reported in human eccrine sweat glands. Objectives We investigated the…”
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Effects of Long-Term Grapefruit Juice Ingestion on Nifedipine Pharmacokinetics: Induction of Rat Hepatic P-450 by Grapefruit Juice
Published in Drug metabolism and disposition (01-04-2000)“…We studied the effects of short- and long-term ingestion of grapefruit juice (GJ) on nifedipine (NFP) pharmacokinetics in rats. Thirty minutes after…”
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Ventricular efficiency predicted by an analytical model
Published in The American journal of physiology (01-06-1986)“…Based on the recent data from the literature, we derived analytic expressions for ventricular stroke work (SW), ventricular O2 consumption, and the ratio of…”
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Macrophage Chemoattractant Protein-1 Deficiency Fails to Restrain Macrophage Infiltration Into Adipose Tissue
Published in Diabetes (New York, N.Y.) (01-05-2008)“…OBJECTIVE--Monocyte chemoattractant protein-1 (MCP-1), a CC-motif chemokine, has been proposed to play critical roles in insulin resistance and recruitment of…”
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