Search Results - "Sagar, D."

Multifaceted interactions mediated by intrinsically disordered regions play key roles in alpha synuclein aggregation by Khare, Sagar D., Chinchilla, Priscilla, Baum, Jean

“…The aggregation of Alpha Synuclein (α-Syn) into fibrils is associated with the pathology of several neurodegenerative diseases. Pathologic aggregates of α-Syn…”
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Catalytic Atroposelective Synthesis of N‑Aryl Quinoid Compounds by Vaidya, Sagar D, Toenjes, Sean T, Yamamoto, Nobuyuki, Maddox, Sean M, Gustafson, Jeffrey L

“…Diarylamines and related scaffolds are among the most common chemotypes in modern drug discovery. While they can potentially possess two chiral axes, there are…”
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Computational structure prediction provides a plausible mechanism for electron transfer by the outer membrane protein Cyc2 from Acidithiobacillus ferrooxidans by Jiang, Virginia, Khare, Sagar D., Banta, Scott

“…Cyc2 is the key protein in the outer membrane of Acidithiobacillus ferrooxidans that mediates electron transfer between extracellular inorganic iron and the…”
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Strengthening science, technology, and innovation-based incubators to help achieve Sustainable Development Goals: Lessons from India by Surana, Kavita, Singh, Anuraag, Sagar, Ambuj D

“…Policymakers in developing countries increasingly see science, technology, and innovation (STI) as an avenue for meeting sustainable development goals (SDGs),…”
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RosettaScripts: a scripting language interface to the Rosetta macromolecular modeling suite by Fleishman, Sarel J, Leaver-Fay, Andrew, Corn, Jacob E, Strauch, Eva-Maria, Khare, Sagar D, Koga, Nobuyasu, Ashworth, Justin, Murphy, Paul, Richter, Florian, Lemmon, Gordon, Meiler, Jens, Baker, David

“…Macromolecular modeling and design are increasingly useful in basic research, biotechnology, and teaching. However, the absence of a user-friendly modeling…”
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De novo enzyme design using Rosetta3 by Richter, Florian, Leaver-Fay, Andrew, Khare, Sagar D, Bjelic, Sinisa, Baker, David

“…The Rosetta de novo enzyme design protocol has been used to design enzyme catalysts for a variety of chemical reactions, and in principle can be applied to any…”
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Aryne Insertion Reactions Leading to Bioactive Fused Quinazolinones: Diastereoselective Total Synthesis of Cruciferane by Vaidya, Sagar D, Argade, Narshinha P

“…Insertion reactions of an in situ generated arynes to a variety of suitably substituted 1,3-quinazolin-4-ones have been demonstrated for a new efficient…”
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Construction of Highly Functionalized Xanthones via Rh-Catalyzed Cascade C–H Activation/O‑Annulation by Nale, Sagar D, Maiti, Debabrata, Lee, Yong Rok

“…A facile and efficient strategy for obtaining functionalized and multihydroxylated xanthones via Rh catalysis under redox-neutral conditions is developed…”
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NOx‐Induced Changes in Upper Tropospheric O3 During the Asian Summer Monsoon in Present‐Day and Future Climate by Roy, Chaitri, Rathod, Sagar D., Ayantika, D. C.

“…The upper tropospheric ozone (O3) strongly influences the atmosphere's radiative budget. Using the Aerosol and Chemistry Model Intercomparison Project…”
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Data-driven supervised learning of a viral protease specificity landscape from deep sequencing and molecular simulations by Pethe, Manasi A., Rubenstein, Aliza B., Khare, Sagar D.

“…Biophysical interactions between proteins and peptides are key determinants of molecular recognition specificity landscapes. However, an understanding of how…”
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Enantioselective Synthesis of α‑Trifluoromethyl Amines via Biocatalytic N–H Bond Insertion with Acceptor-Acceptor Carbene Donors by Nam, Donggeon, Tinoco, Antonio, Shen, Zhuofan, Adukure, Ronald D, Sreenilayam, Gopeekrishnan, Khare, Sagar D, Fasan, Rudi

“…The biocatalytic toolbox has recently been expanded to include enzyme-catalyzed carbene transfer reactions not occurring in Nature. Herein, we report the…”
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Approaches toward Atropisomerically Stable and Conformationally Pure Diarylamines by Vaidya, Sagar D., Heydari, Beeta S., Toenjes, Sean T., Gustafson, Jeffrey L.

“…Diarylamines possess two potentially atropisomeric C–N axes; however, there are few examples of atropisomerically stable diarylamines in the literature, as the…”
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Structures of the peptide-modifying radical SAM enzyme SuiB elucidate the basis of substrate recognition by Davis, Katherine M., Schramma, Kelsey R., Hansen, William A., Bacik, John P., Khare, Sagar D., Seyedsayamdost, Mohammad R., Ando, Nozomi

“…Posttranslational modification of ribosomally synthesized peptides provides an elegant means for the production of biologically active molecules known as RiPPs…”
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Development of SLNs from natural lipids: Application to topical delivery of tretinoin by Mandawgade, Sagar D., Patravale, Vandana B.

“…The aim of this investigation was to develop solid lipid nanoparticles (SLNs) from indigenous, natural solid lipids by using a simple microemulsion technique…”
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Sacituzumab Govitecan in Metastatic Triple-Negative Breast Cancer by Bardia, Aditya, Hurvitz, Sara A, Tolaney, Sara M, Loirat, Delphine, Punie, Kevin, Oliveira, Mafalda, Brufsky, Adam, Sardesai, Sagar D, Kalinsky, Kevin, Zelnak, Amelia B, Weaver, Robert, Traina, Tiffany, Dalenc, Florence, Aftimos, Philippe, Lynce, Filipa, Diab, Sami, Cortés, Javier, O’Shaughnessy, Joyce, Diéras, Véronique, Ferrario, Cristiano, Schmid, Peter, Carey, Lisa A, Gianni, Luca, Piccart, Martine J, Loibl, Sibylle, Goldenberg, David M, Hong, Quan, Olivo, Martin S, Itri, Loretta M, Rugo, Hope S

“…Patients with metastatic triple-negative breast cancer were treated with standard chemotherapy or the anti–Trop-2 antibody–drug conjugate sacituzumab…”
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Recent progress in designing protein-based supramolecular assemblies by Hansen, William A, Khare, Sagar D

“…The design of protein-based assemblies is an emerging area in bionanotechnology with wide ranging applications, from vaccines to smart biomaterials. Design…”
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Impact of Changes to the Atmospheric Soluble Iron Deposition Flux on Ocean Biogeochemical Cycles in the Anthropocene by Hamilton, Douglas S., Moore, J. Keith, Arneth, Almut, Bond, Tami C., Carslaw, Ken S., Hantson, Stijn, Ito, Akinori, Kaplan, Jed O., Lindsay, Keith, Nieradzik, Lars, Rathod, Sagar D., Scanza, Rachel A., Mahowald, Natalie M.

“…Iron can be a growth‐limiting nutrient for phytoplankton, modifying rates of net primary production, nitrogen fixation, and carbon export ‐ highlighting the…”
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Recent (1980 to 2015) Trends and Variability in Daily‐to‐Interannual Soluble Iron Deposition from Dust, Fire, and Anthropogenic Sources by Hamilton, Douglas S., Scanza, Rachel A., Rathod, Sagar D., Bond, Tami C., Kok, Jasper F., Li, Longlei, Matsui, Hitoshi, Mahowald, Natalie M.

“…The iron cycle is a key component of the Earth system. Yet how variable the atmospheric flux of soluble (bioaccessible) iron into oceans is, and how this…”
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Case 3: Acute Right Lower Quadrant Abdominal Pain in a 2-year-old by Mehta, Sagar D, Ng, Carrie

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Biomolecular Condensates: Sequence Determinants of Phase Separation, Microstructural Organization, Enzymatic Activity, and Material Properties by Schuster, Benjamin S, Regy, Roshan Mammen, Dolan, Elliott M, Kanchi Ranganath, Aishwarya, Jovic, Nina, Khare, Sagar D, Shi, Zheng, Mittal, Jeetain

“…This perspective article highlights recent progress and emerging challenges in understanding the formation and function of membraneless organelles (MLOs). A…”
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