Search Results - "Sagal, John"

Development of an Early-Phase Bulk Enabling Route to Sodium-Dependent Glucose Cotransporter 2 Inhibitor Ertugliflozin by Bernhardson, David, Brandt, Thomas A, Hulford, Catherine A, Lehner, Richard S, Preston, Brian R, Price, Kristin, Sagal, John F, St. Pierre, Michael J, Thompson, Peter H, Thuma, Benjamin

“…The development and optimization of a scalable synthesis of sodium-dependent glucose cotransporter 2 inhibitor, ertugliflozin, for the treatment of type-2…”
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Catalytic and Enantioselective Route to Medium-Ring Heterocycles. Asymmetric Zirconium-Catalyzed Ethylmagnesation of Seven- and Eight-Membered Rings by Visser, Michael S, Heron, Nicola M, Didiuk, Mary T, Sagal, John F, Hoveyda, Amir H

“…A variety of medium-ring heterocycles, prepared efficiently by the Ru-catalyzed diene metathesis method, undergo asymmetric catalytic ethylmagnesation to…”
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Metabolism-Guided Design of Short-Acting Calcium-Sensing Receptor Antagonists by Southers, James A, Bauman, Jonathan N, Price, David A, Humphries, Paul S, Balan, Gayatri, Sagal, John F, Maurer, Tristan S, Zhang, Yan, Oliver, Robert, Herr, Michael, Healy, David R, Li, Mei, Kapinos, Brendon, Fate, Gwendolyn D, Riccardi, Keith A, Paralkar, Vishwas M, Brown, Thomas A, Kalgutkar, Amit S

“…As part of a strategy to deliver short-acting calcium-sensing receptor (CaSR) antagonists, the metabolically labile thiomethyl functionality was incorporated…”
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The conversion of alcohols to halides using a filterable phosphine source by Pollastri, Michael P, Sagal, John F, Chang, George

“…The conversion of primary and secondary alcohols to chlorides and bromides using 1,2-bis(diphenylphosphino)ethane (diphos) is described. Use of this reagent in…”
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Synthesis of Quinazolin-4(3H)‑ones via Amidine N‑Arylation by Li, Bryan, Samp, Lacey, Sagal, John, Hayward, Cheryl M, Yang, Christine, Zhang, Zhijun

“…Pyrido[4,3-d]pyrimidin-4(3H)-one (1) was prepared by reacting 2-trifluoromethyl-4-iodo-nicotinic acid (2) with amidine 9a catalyzed by Pd2(dba)3 and Xantphos,…”
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Early Process Development of PF-07054894, a Squaramide-Based Antagonist of C–C Chemokine Receptor Type 6 (CCR6) by Chinigo, Gary M., McInturff, Emma L., Bagley, Scott W., Barnhart, Richard W., Blakemore, David C., Han, Lu, Lee, Taegyo, Magano, Javier, McWilliams, J. Christopher, Monfette, Sebastien, Mousseau, James J., Pan, Senliang, Pedro, Dylan, Perfect, Hahdi H., Raggon, Jeffrey W., Rose, Peter R., Sagal, John, Trujillo, John I., Van Haitsma, Jared, Vetelino, Michael G., Yang, Xiaojing Helen

“…The original synthesis of a CCR6 antagonist and subsequent enablement for kilogram manufacture is presented. Highlighted improvements made in the preparation…”
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Process Development of a Second Generation β‑Amyloid-Cleaving Enzyme InhibitorImproving the Robustness of a Halogen-Metal Exchange Using Continuous Stirred-Tank Reactors by Li, Bryan, Barnhart, Richard W, Dion, Amelie, Guinness, Steven, Happe, Alan, Hayward, Cheryl M, Kohrt, Jeffrey, Makowski, Teresa, Maloney, Mark, Nelson, Jade D, Nematalla, Asaad, McWilliams, J. Christopher, Peng, Zhihui, Raggon, Jeffrey, Sagal, John, Weisenburger, Gerald A, Bao, Denghui, Gonzalez, Miguel, Lu, Jiangping, McLaws, Mark D, Tao, Jian, Wu, Baolin

“…Process development for the synthesis of a second generation β-amyloid-cleaving enzyme (BACE1) inhibitor (1) is described. The lithiothiazole addition to the…”
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THE CONDENSATION OF AMINOANTIPYRINE. VII. HYDROLYSIS IN THE PRESENCE OF NITROUS ACID (1)1 by EMERSON, EDGAR, SAGAL, JOHN

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Fluorinated Aminoanthraquinone Dyes by Dickey, J. B., Towne, E. B., Bloom, M. S., Taylor, G. J., Wallace, D. J., Sagal, John, McCall, M. A., Hedberg, D. G.

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