Search Results - "Sağlık Özkan, Begüm Nurpelin"

Design, Synthesis, and Evaluation of New Pyrazolines As Small Molecule Inhibitors of Acetylcholinesterase by Altıntop, Mehlika Dilek, Sağlık Özkan, Begüm Nurpelin, Özdemir, Ahmet

“…In pursuit of identifying small molecule inhibitors of acetylcholinesterase (AChE), the synthesis of new 2-pyrazolines was performed efficiently. A modified…”
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New Benzimidazole-Triazole Derivatives as Topoisomerase I Inhibitors: Design, Synthesis, Anticancer Screening, and Molecular Modeling Studies by Çevik, Ulviye Acar, Kaya, Betül, Celik, Ismail, Rudrapal, Mithun, Rakshit, Gourav, Karayel, Arzu, Levent, Serkan, Osmaniye, Derya, Sağlık Özkan, Begüm Nurpelin, Baysal, Merve, Atlı Ekliog̈lu, Özlem, Özkay, Yusuf, Kaplancıklı, Zafer Asım

“…In this study, we designed, synthesized, and evaluated a series of 1,2,4-triazole benzimidazoles for their cytotoxic effects against the A549, C6, and NIH3T3…”
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Synthesis of Sorafenib−Ruthenium Complexes, Investigation of Biological Activities and Applications in Drug Delivery Systems as an Anticancer Agent by Zengin Kurt, Belma, Öztürk Civelek, Dilek, Çakmak, Elmas Begüm, Kolcuoğlu, Yakup, Şenol, Halil, Sağlık Özkan, Begüm Nurpelin, Dag, Aydan, Benkli, Kadriye

“…Sorafenib, a multiple kinase inhibitor, is widely used as a first-line treatment for hepatocellular carcinoma. However, there is a need for more effective…”
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Design, synthesis, and investigation of biological activities of new triazole derivatives with antifungal effect by Göktaş, Bünyamin, Osmaniye, Derya, Levent, Serkan, Sağlık Özkan, Begüm Nurpelin, Özkay, Yusuf, Kaplancıklı, Zafer Asım

“…•New triazole derivatives were synthesized as antifungal agents.•MIC50 values were observed against C. albicans strain 4c, 4f and 4 g.•Compound 4c showed the…”
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Synthesis of new piperazine‐oxadiazole derivatives and investigation of their anticancer activities by Uslu, Harun, Göktaş, Bünyamin, Osmaniye, Derya, Levent, Serkan, Göktaş, Sare Peçe, Sağlık Özkan, Begüm Nurpelin, Özkay, Yusuf, Benkli, Kadriye

“…•10 novel Piperazine-Oxadiazole hybrid derivatives were synthesized.•A good ADME profile were predicted for all the synthesized compounds.•The compound 4b…”
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Design, synthesis, biological evaluation, and molecular modeling simulations of new phthalazine‐1,4‐dione derivatives as anti‐Alzheimer's agents by Nuha, Demokrat, Evren, Asaf Evrim, Özkan, Begüm Nurpelin Sağlık, Gundogdu‐Karaburun, Nalan, Karaburun, Ahmet Çagri

“…The development of targeted phthalazine‐1,4‐dione acetylcholinesterase (AChE) inhibitors for treating Alzheimer's disease involved the synthesis of 32…”
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Synthesis of new N‐(5,6‐methylenedioxybenzothiazole‐2‐yl)‐2‐[(substituted)thio/piperazine]acetamide/propanamide derivatives and evaluation of their AChE, BChE, and BACE‐1 inhibitory activities by Tutuş, Beyzanur, Kaya, Aybüke Züleyha, Baz, Yonca, Evren, Asaf Evrim, Sağlik Özkan, Begüm Nurpelin, Yurttaş, Leyla

“…In this study, the synthesis of N‐(5,6‐methylenedioxybenzothiazole‐2‐yl)‐2‐[(substituted)thio/piperazine]acetamide/propanamide derivatives (3a‐3k) and to…”
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Pharmacophore‐Based Modeling, Synthesis, and Biological Evaluation of Novel Quinazoline/Quinoline Derivatives: Discovery of EGFR Inhibitors with Low Nanomolar Activity by Evren, Asaf Evrim, Sağlik Özkan, Begüm Nurpelin, Akalin‐Çiftçi, Gülşen, Yurttaş, Leyla

“…The main aim of this study is to obtain novel molecules that are more selective on cancer cells compared to healthy cells. For this purpose, four hit molecules…”
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New 2-hydrazinothiazole derivatives as potential MAO-A, MAO-B, AChE, and BChE inhibitors by Tutuş, Beyzanur, Evren, Asaf Evrim, Sağlik Özkan, Begüm Nurpelin, Yurttaş, Leyla

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