MSCT enterography score for prediction of disease severity in patients with active ulcerative colitis

Background Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease (IBD). It is characterized by diffuse inflammatory process of the bowel mucosa with a relapsing course. The precise evaluation of UC severity is pivotal in the therapeutic decision-making. Modified Mayo score is...

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Bibliographic Details
Published in:	Egyptian journal of radiology and nuclear medicine Vol. 55; no. 1; pp. 190 - 12
Main Authors:	Ali, Rasha Mostafa Mohamed, Soliman, Mirna Sami, Shehab, Hany, Hashem, Mohamed Bassam, Al-Sharif, Aya M, Safwat, Merit, Elnafrawy, Marwa Shaker Abd Elfattah
Format:	Journal Article
Language:	English
Published:	Cairo Springer 01-12-2024 Springer Nature B.V SpringerOpen
Subjects:	Care and treatment CTE score Development and progression Disease severity Endoscopy Erythema Females Health aspects Inflammatory bowel disease Medical imaging Modified Mayo score Patients Scanners Ulcerative colitis Variance analysis Taiwan
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Summary:	Background Ulcerative colitis (UC) is a chronic non-specific inflammatory bowel disease (IBD). It is characterized by diffuse inflammatory process of the bowel mucosa with a relapsing course. The precise evaluation of UC severity is pivotal in the therapeutic decision-making. Modified Mayo score is consistently used for the evaluation of the disease activity which depends on the patient's symptoms as well as the colonoscopic findings. The aim of this study is to assess the role of the CT enterography (CTE) scoring system in the evaluation of the disease severity in ulcerative colitis. From October 2022 to July 2023, 66 patients with known ulcerative colitis patients at time of disease activity were referred from the inflammatory bowel disease unit for radiological assessment by CTE. CT images were analyzed to determine the anatomical location of the affected bowel segments, mucosal thickening and hyperenhancement as well as the extra-enteric involvement. Correlation with the modified Mayo score was established. Results Our results showed a statistical significant correlation between modified Mayo score and CTE with a P value of 0.000. The correlation coefficient is r = 0.964. The cut-off value of the optimal CTE score to predict mild and moderate UC was 7.5 with 0.996 area under the ROC curve, 92%sensitivity and 100% specificity. The cut-off value of the optimal CTE score to predict moderate and severe UC was 10.5 with 0.983 area under the ROC curve, 90.6% sensitivity and 100% specificity. Conclusions CTE is a reliable diagnostic method in the systematic assessment of the disease severity of active ulcerative colitis. CTE score shows a strong proportionate correlation with modified Mayo score. The aggravation of the course of the disease increased the CTE score. CTE scoring system can help plan the therapeutic strategy and predict prognosis.
ISSN:	0378-603X 2090-4762
DOI:	10.1186/s43055-024-01344-6