Search Results - "Safont, Maria José"

Analysis of c-kit expression in small cell lung cancer: Prevalence and prognostic implications by Camps, Carlos, Sirera, Rafael, Bremnes, Roy M., Garde, Javier, Safont, María José, Blasco, Ana, Berrocal, Alfonso, Sánchez, José Javier, Calabuig, Consuelo, Martorell, Miguel

“…c-kit, a growth factor receptor with tyrosine kinase activity, plays an important role in the biology of cancer. Its expression has been documented in several…”
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Retrospective study of efficacy and toxicity on patients older than 70 years within a randomized clinical trial of two cisplatin-based combinations in patients with small-cell lung cancer by Safont, María José, Artal-Cortes, Ángel, Sirera, Rafael, Gómez-Codina, José, González-Larriba, José Luis, Barneto, Isidoro, Carrato, Alfredo, Isla, Dolores, Rosell, Rafael, Camps, Carlos

“…Summary A retrospective analysis based on the Spanish Lung Cancer Group (SLCG) clinical trial of high-dose epirubicin/cisplatin in patients with small-cell…”
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ETV6::NTRK3 Fusion-Positive Wild-Type Gastrointestinal Stromal Tumor (GIST) with Abundant Lymphoid Infiltration (TILs and Tertiary Lymphoid Structures): A Report on a New Case with Therapeutic Implications and a Literature Review by Machado, Isidro, Claramunt-Alonso, Reyes, Lavernia, Javier, Romero, Ignacio, Barrios, María, Safont, María José, Santonja, Nuria, Navarro, Lara, López-Guerrero, José Antonio, Llombart-Bosch, Antonio

“…Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the gastrointestinal tract, with proto-oncogene, receptor tyrosine kinase (…”
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SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021) by Capdevila, Jaume, Gómez, Ma Auxiliadora, Guillot, Mónica, Páez, David, Pericay, Carles, Safont, Maria José, Tarazona, Noelia, Vera, Ruth, Vidal, Joana, Sastre, Javier

“…The management of localized rectal cancer requires a multidisciplinary approach to optimize outcomes, reduce morbidity and prevent under or overtreatments…”
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Addition of Bevacizumab to XELOX Induction Therapy Plus Concomitant Capecitabine‐Based Chemoradiotherapy in Magnetic Resonance Imaging–Defined Poor‐Prognosis Locally Advanced Rectal Cancer: The AVACROSS Study by Nogué, Miguel, Salud, Antonieta, Vicente, Pilar, Arriví, Antonio, Roca, José María, Losa, Ferran, Ponce, José, Safont, María José, Guasch, Inmaculada, Moreno, Isabel, Ruiz, Ana, Pericay, Carles

“…Background. Concomitant chemoradiotherapy followed by total mesorectal excision is standard treatment for locally advanced rectal cancer. This approach,…”
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Quantification in the Serum of the Catalytic Fraction of Reverse Telomerase: A Useful Prognostic Factor in Advanced Non-small Cell Lung Cancer by CAMPS, Carlos, SIRERA, Rafael, TARON, Miquel, ROSELL, Rafael, BREMNES, Roy M, RODENAS, Vanessa, BLASCO, Ana, SAFONT, Maria José, GARDE, Javier, JUAREZ, Asuncion, CABALLERO, Cristina, SANCHEZ, José Javier

“…The purpose of this analysis was to study the association between the quantity of free circulating DNA and clinical variables in 99 advanced non-small cell…”
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Phase II randomized trial of capecitabine with bevacizumab and external beam radiation therapy as preoperative treatment for patients with resectable locally advanced rectal adenocarcinoma: long term results by Salazar, Ramón, Capdevila, Jaume, Manzano, Jose Luis, Pericay, Carles, Martínez-Villacampa, Mercedes, López, Carlos, Losa, Ferrán, Safont, María José, Gómez-España, Auxiliadora, Alonso-Orduña, Vicente, Escudero, Pilar, Gallego, Javier, García-Paredes, Beatriz, Palacios, Amalia, Biondo, Sebastiano, Grávalos, Cristina, Aranda, Enrique

“…Preoperative chemoradiotherapy with capecitabine is considered as a standard of care for locally advanced rectal cancer. The "Tratamiento de Tumores…”
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Relationship between oral microbiota and colorectal cancer: A systematic review by Camañes-Gonzalvo, Sara, Montiel-Company, José María, Lobo-de-Mena, Miriam, Safont-Aguilera, María José, Fernández-Diaz, Amaya, López-Roldán, Andrés, Paredes-Gallardo, Vanessa, Bellot-Arcís, Carlos

“…This systematic review aims to investigate the microbial basis underlying the association between oral microbiota and colorectal cancer. A comprehensive search…”
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Management of adverse events during treatment of gastrointestinal cancers with epidermal growth factor inhibitors by Hofheinz, Ralf-Dieter, Segaert, Siegfried, Safont, María José, Demonty, Gaston, Prenen, Hans

“…Highlights • EGFR inhibitors are better tolerated than chemotherapy but have specific toxicities. • Healthcare professionals must be aware of these…”
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First-line panitumumab plus FOLFOX4 or FOLFIRI in colorectal cancer with multiple or unresectable liver metastases: A randomised, phase II trial (PLANET-TTD) by Carrato, Alfredo, Abad, Albert, Massuti, Bartomeu, Grávalos, Cristina, Escudero, Pilar, Longo-Muñoz, Federico, Manzano, José-Luis, Gómez, Auxiliadora, Safont, María José, Gallego, Javier, García-Paredes, Beatriz, Pericay, Carles, Dueñas, Rosario, Rivera, Fernando, Losa, Ferrán, Valladares-Ayerbes, Manuel, González, Encarnación, Aranda, Enrique

“…Abstract Background In first-line wild-type (WT)-Kirsten rat sarcoma viral oncogene homologue ( KRAS ) metastatic colorectal cancer (mCRC), panitumumab (Pmab)…”
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Retrospective analysis of the prognostic role of p16 protein inactivation in plasma in patients with locally advanced non-small cell lung cancer by Sirera, Rafael, Gil, Mireia, Blasco, Ana, Cabrera, Andrea, Safont, María José, Iranzo, Vega, Cayuela, Diego, Rosell, Rafael, Camps, Carlos

“…Summary It has been analyzed the frequency of p16 inactivation in 67 blood samples of patients diagnosed with advanced non-small cell lung cancer (NSCLC), to…”
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Preoperative Chemotherapy in Patients With Intermediate‐Risk Rectal Adenocarcinoma Selected by High‐Resolution Magnetic Resonance Imaging: The GEMCAD 0801 Phase II Multicenter Trial by Fernandez‐Martos, Carlos, Brown, Gina, Estevan, Rafael, Salud, Antonieta, Montagut, Clara, Maurel, Joan, Safont, Maria Jose, Aparicio, Jorge, Feliu, Jaime, Vera, Ruth, Alonso, Vicente, Gallego, Javier, Martin, Marta, Pera, Miguel, Sierra, Enrique, Serra, Javier, Delgado, Salvadora, Roig, Jose V., Santos, Jesus, Pericay, Carles

“…Background. The need for preoperative chemoradiation or short‐course radiation in all T3 rectal tumors is a controversial issue. A multicenter phase II trial…”
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Effect of aflibercept plus FOLFIRI and potential efficacy biomarkers in patients with metastatic colorectal cancer: the POLAF trial by Élez, Elena, Gómez-España, María Auxiliadora, Grávalos, Cristina, García-Alfonso, Pilar, Ortiz-Morales, María José, Losa, Ferrán, Díaz, Inmaculada Alés, Graña, Begoña, Toledano-Fonseca, Marta, Valladares-Ayerbes, Manuel, Polo, Eduardo, Salgado, Mercedes, Martínez de Castro, Eva, Safont, María José, Salud, Antonieta, Ruiz-Casado, Ana, Tabernero, Josep, Riesco, María del Carmen, Rodriguez-Ariza, Antonio, Aranda, Enrique

“…Background Aflibercept is an antiangiogenic drug against metastatic colorectal cancer (mCRC) combined with 5-fluorouracil/leucovorin/irinotecan (FOLFIRI);…”
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Upfront primary tumour resection and survival in synchronous metastatic colorectal cancer according to primary tumour location and RAS status: Pooled analysis of the Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) by Benavides, Manuel, Gómez-España, Auxiliadora, García-Alfonso, Pilar, González, Cristina García, Viéitez, Jose María, Rivera, Fernando, Safont, María José, Abad, Albert, Sastre, Javier, Valladares-Ayerbes, Manuel, Carrato, Alfredo, González-Flores, Encarnación, Robles, Luis, Salud, Antonieta, Alonso-Orduña, Vicente, Montagut, Clara, Asensio, Elena, Díaz-Rubio, Eduardo, Aranda, Enrique

“…Retrospective studies and meta-analyses suggest that upfront primary tumour resection (UPTR) confers a survival benefit in patients with asymptomatic…”
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CpG Island Hypermethylation of the DNA Repair Enzyme Methyltransferase Predicts Response to Temozolomide in Primary Gliomas by PAZ, Maria F, YAYA-TUR, Ricard, SANCHEZ-CESPEDES, Montserrat, GARCIA-VILLANUEVA, Mercedes, ARRIBAS, Leoncio, ESTELLER, Manel, ROJAS-MARCOS, Inigo, REYNES, Gaspar, POLLAN, Marina, AGUIRRE-CRUZ, Lucinda, GARCIA-LOPEZ, Jose Luis, PIQUER, Jose, SAFONT, Maria-Jose, BALANA, Carmen

“…Purpose: The DNA repair enzyme O 6 -methylguanine DNA methyltransferase (MGMT) inhibits the killing of tumor cells by alkylating agents, and its loss in cancer…”
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Clinicopathological and Molecular Characterization of Metastatic Gastrointestinal Stromal Tumors with Prolonged Benefit to Frontline Imatinib by Serrano, César, García‐del‐Muro, Xavier, Valverde, Claudia, Sebio, Ana, Durán, José, Manzano, Aránzazu, Pajares, Isabel, Hindi, Nadia, Landolfi, Stefania, Jiménez, Laura, Rubió‐Casadevall, Jordi, Estival, Anna, Lavernia, Javier, Safont, María José, Pericay, Carles, Díaz‐Beveridge, Roberto, Martínez‐Marín, Virginia, Vicente‐Baz, David, Vivancos, Ana, Hernández‐Losa, Javier, Arribas, Joaquín, Carles, Joan

“…Background Oncogenic KIT/PDGFRA signaling inhibition with imatinib achieves disease control in most patients with advanced/metastatic gastrointestinal stromal…”
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Sequential RAS mutations evaluation in cell-free DNA of patients with tissue RAS wild-type metastatic colorectal cancer: the PERSEIDA (Cohort 2) study by Valladares-Ayerbes, Manuel, Safont, Maria José, González Flores, Encarnación, García-Alfonso, Pilar, Aranda, Enrique, Muñoz, Ana-Maria López, Falcó Ferrer, Esther, Cirera Nogueras, Luís, Rodríguez-Salas, Nuria, Aparicio, Jorge, Llanos Muñoz, Marta, Pimentel Cáceres, Paola Patricia, Castillo Trujillo, Oscar Alfredo, Vidal Tocino, Rosario, Salgado Fernández, Mercedes, Salud-Salvia, Antonieta, Massuti Sureda, Bartomeu, Garcia-Carbonero, Rocio, Vicente Conesa, Maria Ángeles, Lloansí Vila, Ariadna

“…Purpose RAS ( KRAS / NRAS ) mutational status on a tumor biopsy is mandatory to guide the best treatment in metastatic colorectal cancer (mCRC). Determining…”
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Diversity of oncopharmacogenetic profile within Spanish population by Ferrer Bolufer, Irene, Galiana Vallés, Ximo, Izquierdo Álvarez, Silvia, Serrano Mira, Ana, Guzmán Luján, Carola, Safont Aguilera, María José, González Tarancón, Ricardo, Bolaños Naranjo, Matilde, Carrasco Salas, Pilar, Santamaría González, María, Rodríguez-López, Raquel

“…Consensus guidelines for genotype-guided fluoropyrimidine dosing based on variation in the dihydropyrimidine dehydrogenase (DPYD) gene before treatment have…”
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FOLFOXIRI plus bevacizumab versus FOLFOX plus bevacizumab for patients with metastatic colorectal cancer and ≥3 circulating tumour cells: the randomised phase III VISNÚ-1 trial by Aranda, Enrique, Viéitez, Jose Maria, Gómez-España, Auxiliadora, Gil Calle, Silvia, Salud-Salvia, Antonieta, Graña, Begoña, Garcia-Alfonso, Pilar, Rivera, Fernando, Quintero-Aldana, Guillermo Alfonso, Reina-Zoilo, Juan José, González-Flores, Encarnación, Salgado Fernández, Mercedes, Guillén‑Ponce, Carmen, Garcia-Carbonero, Rocio, Safont, María José, La Casta Munoa, Adelaida, García-Paredes, Beatriz, López López, Rafael, Sastre, Javier, Díaz-Rubio, Eduardo

“…Purpose5-Fluorouracil/leucovorin, oxaliplatin, irinotecan (FOLFOXIRI) plus bevacizumab is more effective than doublets plus bevacizumab as first-line therapy…”
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Correlation of RECIST, Computed Tomography Morphological Response, and Pathological Regression in Hepatic Metastasis Secondary to Colorectal Cancer: The AVAMET Study by Vera, Ruth, Gómez, María Luisa, Ayuso, Juan Ramón, Figueras, Joan, García-Alfonso, Pilar, Martínez, Virginia, Lacasta, Adelaida, Ruiz-Casado, Ana, Safont, María José, Aparicio, Jorge, Campos, Juan Manuel, Cámara, Juan Carlos, Martín-Richard, Marta, Montagut, Clara, Pericay, Carles, Vieitez, Jose María, Falcó, Esther, Jorge, Mónica, Marín, Miguel, Salgado, Mercedes, Viúdez, Antonio

“…Background: The prospective phase IV AVAMET study was undertaken to correlate response evaluation criteria in solid tumors (RECIST)-defined response rates with…”
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