Search Results - "Safirstein, Robert L"

APOBEC-1 deletion enhances cisplatin-induced acute kidney injury by Guo, Xiaojia, Blanc, Valerie, Davidson, Nicholas O., Velazquez, Heino, Chen, Tian-min, Moledina, Dennis G., Moeckel, Gilbert W., Safirstein, Robert L., Desir, Gary V.

“…Cisplatin (CP) induces acute kidney injury (AKI) whereby proximal tubules undergo regulated necrosis. Repair is almost complete after a single dose. We now…”
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Cisplatin-induced cell death is EGFR/src/ERK signaling dependent in mouse proximal tubule cells by Arany, Istvan, Megyesi, Judit K, Kaneto, Hideaki, Price, Peter M, Safirstein, Robert L

“…Cisplatin treatment induces extensive death of the proximal tubules in mice. We also demonstrated that treatment of immortalized mouse proximal tubule cells…”
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Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo by Yu, Fang, Megyesi, Judit, Safirstein, Robert L, Price, Peter M

“…E2F1 is a key regulator that links cell cycle progression and cell death. E2F1 activity is controlled by Cdk2-cyclin complexes via several mechanisms, such as…”
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Protection of renal cells from cisplatin toxicity by cell cycle inhibitors by Price, Peter M, Safirstein, Robert L, Megyesi, Judit

“…The optimal use of cisplatin as a chemotherapeutic drug has been limited by its nephrotoxicity. Murine models have been used to study cisplatin-induced acute…”
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AMP-activated protein kinase contributes to cisplatin-induced renal epithelial cell apoptosis and acute kidney injury by Jin, Xiaogao, An, Changlong, Jiao, Baihai, Safirstein, Robert L, Wang, Yanlin

“…Cisplatin, a commonly used anticancer drug, has been shown to induce acute kidney injury, which limits its clinical use in cancer treatment. Emerging evidence…”
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Deletion of LOX-1 attenuates renal injury following angiotensin II infusion by Hu, Changping, Kang, Bum-Yong, Megyesi, Judit, Kaushal, Gur P., Safirstein, Robert L., Mehta, Jawahar L.

“…Angiotensin II upregulates the expression of LOX-1, a recently identified oxidized low-density lipoprotein receptor controlled by redox state which in turn…”
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The cell cycle and acute kidney injury by Price, Peter M., Safirstein, Robert L., Megyesi, Judit

“…Acute kidney injury (AKI) activates pathways of cell death and cell proliferation. Although seemingly discrete and unrelated mechanisms, these pathways can now…”
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TAK1 deficiency attenuates cisplatin-induced acute kidney injury by Zhou, Jun, An, Changlong, Jin, Xiaogao, Hu, Zhaoyong, Safirstein, Robert L, Wang, Yanlin

“…Cisplatin can cause acute kidney injury (AKI), but the molecular mechanisms are not well understood. The objective of the present study was to examine the role…”
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Activation of ERK or inhibition of JNK ameliorates H2O2 cytotoxicity in mouse renal proximal tubule cells by Arany, Istvan, Megyesi, Judit K., Kaneto, Hideaki, Tanaka, Sakae, Safirstein, Robert L.

“…Activation of ERK or inhibition of JNK ameliorates H2O2 cytotoxicity in mouse renal proximal tubule cells. Our previous studies suggest that the balance…”
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MAPK activation determines renal epithelial cell survival during oxidative injury by di Mari, J F, Davis, R, Safirstein, R L

“…Ischemia/reperfusion (I/R) injury induces both functional and morphological changes in the kidney. Necrosis, predominantly of the proximal tubule (PT), is the…”
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Cisplatin nephrotoxicity by Arany, Istvan, Safirstein, Robert L

“…Cisplatin remains a major antineoplastic drug for the treatment of solid tumors. Its chief dose-limiting side effect is nephrotoxicity, which evolves slowly…”
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Coordination of the cell cycle is an important determinant of the syndrome of acute renal failure by Megyesi, Judit, Andrade, Lucia, Vieira, Jr, Jose M, Safirstein, Robert L, Price, Peter M

“…Recovery from injury is usually accompanied by cell replication, in which new cells replace those irreparably damaged. After acute renal failure, normally…”
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p66shc Inhibits Pro-survival Epidermal Growth Factor Receptor/ERK Signaling during Severe Oxidative Stress in Mouse Renal Proximal Tubule Cells by Arany, Istvan, Faisal, Amir, Nagamine, Yoshikuni, Safirstein, Robert L.

“…The fully executed epidermal growth factor receptor (EGFR)/Ras/MEK/ERK pathway serves a pro-survival role in renal epithelia under moderate oxidative stress…”
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Am I my brother's keeper?: fratricide in the kidney by Safirstein, Robert L.

“…Experimental acute kidney injury (AKI) is accompanied by the death of renal tubule epithelial cells, necrosis and apoptosis of the terminal portion of the…”
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p66 Inhibits Pro-survival Epidermal Growth Factor Receptor/ERK Signaling during Severe Oxidative Stress in Mouse Renal Proximal Tubule Cells by Arany, Istvan, Faisal, Amir, Nagamine, Yoshikuni, Safirstein, Robert L.

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Restoration of CREB function ameliorates cisplatin cytotoxicity in renal tubular cells by Arany, Istvan, Herbert, Johann, Herbert, Zsolt, Safirstein, Robert L

“…We have shown that mouse proximal tubule cells (TKPTS) survive H(2)O(2) stress by activating the cAMP-responsive element binding protein (CREB)-mediated…”
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Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity by Hodeify, Rawad, Tarcsafalvi, Adel, Megyesi, Judit, Safirstein, Robert L, Price, Peter M

“…Cisplatin cytotoxicity is dependent on cyclin-dependent kinase 2 (Cdk2) activity in vivo and in vitro. We found that an 18-kDa protein identified by mass…”
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Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2 by PRICE, Peter M, FANG YU, KALDIS, Philipp, ALEEM, Eiman, NOWAK, Grazyna, SAFIRSTEIN, Robert L, MEGYESI, Judit

“…Cisplatin is one of the most effective chemotherapeutics, but its usefulness is limited by its toxicity to normal tissues, including cells of the kidney…”
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Thomas E. Andreoli: a personal memorial by Safirstein, Robert L.

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Acute renal failure: From renal physiology to the renal transcriptome by Safirstein, Robert L.

“…Acute renal failure: From renal physiology to the renal transcriptome. Acute renal failure (ARF) is defined as an abrupt fall in glomerular filtration rate…”
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