Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity

Pre/postnatal taurine supplementation improves neurodevelopment and brain function in mice offspring: A persistent developmental study from puberty to maturity

Taurine (TAU) is a sulfur-containing amino acid abundantly found in the human body. Endogenously, TAU is synthesized from cysteine in the liver. However, newborns rely entirely on TAU's dietary supply (milk). There is no investigation on the effect of long-term TAU administration on next-genera...

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Bibliographic Details
Published in:Life sciences (1973) Vol. 336; p. 122284
Main Authors: Ommati, Mohammad Mehdi, Rezaei, Heresh, Socorro, Retana-Márquez, Tian, Weishun, Zhao, Jing, Rouhani, Ayeh, Sabouri, Samira, Ghaderi, Fatemeh, Niknahad, Amir Mohammad, Najibi, Asma, Mazloomi, Sahra, Safipour, Moslem, Honarpishefard, Zahra, Wang, Hong-Wei, Niknahad, Hossein, Heidari, Reza
Format: Journal Article
Language:English
Published: Netherlands 01-01-2024
Subjects:
Neurodevelopment
Mitochondria
Amino acid
Nutrition
Functional food
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Summary:Taurine (TAU) is a sulfur-containing amino acid abundantly found in the human body. Endogenously, TAU is synthesized from cysteine in the liver. However, newborns rely entirely on TAU's dietary supply (milk). There is no investigation on the effect of long-term TAU administration on next-generation neurological development. The current study evaluated the effect of long-term TAU supplementation during the maternal gestational and litter weaning time on several neurological parameters in mice offspring. Moreover, the effects of TAU on mitochondrial function and oxidative stress biomarkers as plausible mechanisms of its action in the whole brain and hippocampus have been evaluated. TAU (0.5 % and 1 % w/v) was dissolved in the drinking water of pregnant mice (Day one of pregnancy), and amino acid supplementation was continued during the weaning time (post-natal day; PND = 21) until litters maturity (PND = 65). It was found that TAU significantly improved cognitive function, memory performance, reflexive motor activity, and emotional behaviors in F1-mice generation. TAU measurement in the brain and hippocampus revealed higher levels of this amino acid. TAU and ATP levels were also significantly higher in the mitochondria isolated from the whole brain and hippocampus. Based on these data, TAU could be suggested as a supplement during pregnancy or in pediatric formula. The effects of TAU on cellular mitochondrial function and energy metabolism might play a fundamental role in the positive effects of this amino acid observed in this investigation.
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ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2023.122284