Search Results - "Saffrey, M Jill"

Postmitotic neurons develop a p21‐dependent senescence‐like phenotype driven by a DNA damage response by Jurk, Diana, Wang, Chunfang, Miwa, Satomi, Maddick, Mandy, Korolchuk, Viktor, Tsolou, Avgi, Gonos, Efstathios S., Thrasivoulou, Christopher, Jill Saffrey, M., Cameron, Kerry, von Zglinicki, Thomas

“…Summary In senescent cells, a DNA damage response drives not only irreversible loss of replicative capacity but also production and secretion of reactive…”
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Aging of the mammalian gastrointestinal tract: a complex organ system by Saffrey, M. Jill

“…Gastrointestinal disorders are a major cause of morbidity in the elderly population. The gastrointestinal tract is the most complex organ system; its diverse…”
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Gastrointestinal capacity, gut hormones and appetite change during rat pregnancy and lactation by Johnson, Michelle L, Saffrey, M Jill, Taylor, Victoria J

“…Pregnancy and lactation increase maternal appetite and adiposity, which in humans can lead to long-term body mass retention. Previous rat reproduction studies…”
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Age-Associated mRNA and miRNA Expression Changes in the Blood-Brain Barrier by Goodall, Emily F, Leach, Vicki, Wang, Chunfang, Cooper-Knock, Johnathan, Heath, Paul R, Baker, David, Drew, David R, Saffrey, M Jill, Simpson, Julie E, Romero, Ignacio A, Wharton, Stephen B

“…Functional and structural age-associated changes in the blood-brain barrier (BBB) may affect the neurovascular unit and contribute to the onset and progression…”
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Plasma Ghrelin Concentrations Were Altered with Oestrous Cycle Stage and Increasing Age in Reproductively Competent Wistar Females by Johnson, Michelle L, Saffrey, M Jill, Taylor, Victoria J

“…Changes in appetite occur during the ovarian cycle in female mammals. Research on appetite-regulatory gastrointestinal peptides in females is limited, because…”
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Cellular changes in the enteric nervous system during ageing by Saffrey, M. Jill

“…The intrinsic neurons of the gut, enteric neurons, have an essential role in gastrointestinal functions. The enteric nervous system is plastic and continues to…”
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Loss of UCHL1 promotes age-related degenerative changes in the enteric nervous system by Coulombe, Josée, Gamage, Prasanna, Gray, Madison T, Zhang, Mei, Tang, Matthew Y, Woulfe, John, Saffrey, M Jill, Gray, Douglas A

“…UCHL1 (ubiquitin carboxyterminal hydrolase 1) is a deubiquitinating enzyme that is particularly abundant in neurons. From studies of a spontaneous mutation…”
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Decreases in mucosally‐evoked tachykinin signaling pathways can explain age‐related reductions in murine colonic motility patterns by Yeoman, Mark S., Fidalgo, Sara, Hobby, India, Hafeez, Ali, Ranson, Rachel N., Saffrey, M. Jill, Patel, Bhavik Anil

“…Background Increasing age increases the incidence of chronic constipation and fecal impaction. The contribution of the natural aging process to this phenotype…”
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Changes in neuromuscular structure and functions of human colon during ageing are region-dependent by Broad, John, Kung, Victor W S, Palmer, Alexandra, Elahi, Shezan, Karami, Azadeh, Darreh-Shori, Taher, Ahmed, Shafi, Thaha, Mohamed Adhnan, Carroll, Rebecca, Chin-Aleong, Joanne, Martin, Joanne E, Saffrey, M Jill, Knowles, Charles H, Sanger, Gareth John

“…To determine if human colonic neuromuscular functions decline with increasing age. Looking for non-specific changes in neuromuscular function, a standard burst…”
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Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats by Johnson, Michelle L., Saffrey, M. Jill, Taylor, Victoria J.

“…•Increased GLP-1 levels were found in plasma and colon tissue during proestrus.•Reduced stomach contents were recorded on the morning of estrus.•High GLP-1 at…”
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The TNF-α antagonist etanercept reverses age-related decreases in colonic SERT expression and faecal output in mice by Patel, Bhavik Anil, Fidalgo, Sara, Wang, Chunfang, Parmar, Leena, Mandona, Kasonde, Panossian, Annabelle, Flint, Melanie S., Ranson, Richard N., Saffrey, M. Jill, Yeoman, Mark S.

“…Treatment for chronic constipation in older people is challenging and the condition has a major impact on quality of life. A lack of understanding about the…”
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Neurogenic mechanisms in bladder and bowel ageing by Ranson, Richard N., Saffrey, M. Jill

“…The prevalence of both urinary and faecal incontinence, and also chronic constipation, increases with ageing and these conditions have a major impact on the…”
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Impaired colonic motility and reduction in tachykinin signalling in the aged mouse by Patel, Bhavik Anil, Patel, Nikkita, Fidalgo, Sara, Wang, Chunfang, Ranson, Richard N., Saffrey, M. Jill, Yeoman, Mark S.

“…Ageing is associated with an increased incidence of constipation in humans. The contribution that the ageing process makes to this condition is unclear. The…”
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Interstitial cell network volume is reduced in the terminal bowel of ageing mice by Gamage, Prasanna P. K. M., Patel, Bhavik A., Yeoman, Mark S., Ranson, Rachel N., Saffrey, M. Jill

“…Ageing is associated with impaired neuromuscular function of the terminal gastrointestinal (GI) tract, which can result in chronic constipation, faecal…”
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Differing effects of NT-3 and GDNF on dissociated enteric ganglion cells exposed to hydrogen peroxide in vitro by Korsak, Kris, Silva, Ayona T., Saffrey, M. Jill

“…► Oxidative stress has been implicated in ageing and disease-related damage of enteric neurons. ► Neurotrophic factors have been reported to have protective…”
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Ageing of the enteric nervous system by Saffrey, M. Jill

“…The intrinsic neurones of the enteric nervous system (ENS) play a fundamental role in the regulation of gastrointestinal functions. Although much remains to be…”
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Ageing of enteric neurons: oxidative stress, neurotrophic factors and antioxidant enzymes by Korsak, Kris, Dolatshad, Nazanin F, Silva, Ayona T, Saffrey, M Jill

“…Background Ageing is associated with gastrointestinal dysfunction, which can have a major impact on quality of life of the elderly. A number of changes in the…”
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Colostrinin alleviates amyloid-beta induced toxicity in rat primary hippocampal cultures by Froud, Kristina E, Wardhaugh, Tina, Banks, Duncan, Saffrey, M Jill, Stewart, Michael G

“…Colostrinin (CLN), a complex mixture of proline-rich polypeptides derived from colostrums, can alleviate cognitive decline in early Alzheimer's disease…”
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Differential expression of glial cell line-derived neurotrophic factor family receptor alpha-2 isoforms in rat urinary bladder and intestine by Dolatshad, Nazanin F., Saffrey, M. Jill

“…Neurturin (NTN) is a member of the glial cell line-derived (GDNF) family of neurotrophic factors, which act via a receptor complex composed of a signal…”
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Identification of GFR α-2 isoforms in myenteric plexus of postnatal and adult rat intestine by Dolatshad, Nazanin F, Silva, Ayona T, Jill Saffrey, M

“…Glial cell line-derived neurotrophic factor family receptor α-2 (GFR α-2) is a GPI-linked receptor that preferentially binds neurturin (NTN), a member of the…”
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