Search Results - "Saffi, Golam T."

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition by Saffi, Golam T, Tang, Evan, Mamand, Sami, Inpanathan, Subothan, Fountain, Aaron, Salmena, Leonardo, Botelho, Roberto J

“…Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and…”
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Characterization of a PIP Binding Site in the N-Terminal Domain of V-ATPase a4 and Its Role in Plasma Membrane Association by Chu, Anh, Yao, Yeqi, Saffi, Golam T, Chung, Ji Hyun, Botelho, Roberto J, Glibowicka, Miroslawa, Deber, Charles M, Manolson, Morris F

“…Vacuolar ATPases (V-ATPases) are multi-subunit ATP-dependent proton pumps necessary for cellular functions, including pH regulation and membrane fusion. The…”
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Lysosome Fission: Planning for an Exit by Saffi, Golam T., Botelho, Roberto J.

“…Lysosomes are acidic and degradative organelles that receive and digest a plethora of molecular and particulate cargo delivered by endocytosis, autophagy, and…”
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Inhibition of lipid kinase PIKfyve reveals a role for phosphatase Inpp4b in the regulation of PI(3)P-mediated lysosome dynamics through VPS34 activity by Saffi, Golam T., Wang, Cheng An, Mangialardi, Emily M., Vacher, Jean, Botelho, Roberto J., Salmena, Leonardo

“…Lysosome membranes contain diverse phosphoinositide (PtdIns) lipids that coordinate lysosome function and dynamics. The PtdIns repertoire on lysosomes is…”
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INPP4B promotes PDAC aggressiveness via PIKfyve and TRPML-1-mediated lysosomal exocytosis by Saffi, Golam T, To, Lydia, Kleine, Nicholas, Melo, Ché M P, Chen, Keyue, Genc, Gizem, Lee, K C Daniel, Chow, Jonathan Tak-Sum, Jang, Gun Ho, Gallinger, Steven, Botelho, Roberto J, Salmena, Leonardo

“…Aggressive solid malignancies, including pancreatic ductal adenocarcinoma (PDAC), can exploit lysosomal exocytosis to modify the tumor microenvironment,…”
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Amyloid-β Inhibits PDGFβ Receptor Activation and Prevents PDGF-BBInduced Neuroprotection by Liu, Hui, Saffi, Golam T, Vasefi, Maryam S, Choi, Youngjik, Kruk, Jeff S, Ahmed, Nawaz, Gondora, Nyasha, Mielke, John, Leonenko, Zoya, Beazely, Michael A

“…PDGFβ receptors and their ligand, PDGF-BB, are upregulated in vivo after neuronal insults such as ischemia. When applied exogenously, PDGF-BB is…”
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