Search Results - "Saffery, R."

The ever growing complexity of placental epigenetics – Role in adverse pregnancy outcomes and fetal programming by Novakovic, B, Saffery, R

“…Abstract As the primary interface between maternal and fetal circulations, the placenta is subject to a myriad of environmental exposures with the capacity to…”
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BDNF promoter methylation and genetic variation in late-life depression by Januar, V, Ancelin, M-L, Ritchie, K, Saffery, R, Ryan, J

“…The regulation of the brain-derived neurotrophic factor (BDNF) is important for depression pathophysiology and epigenetic regulation of the BDNF gene may be…”
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Vitamin D insufficiency in the first 6 months of infancy and challenge‐proven IgE‐mediated food allergy at 1 year of age: a case‐cohort study by Molloy, J., Koplin, J. J., Allen, K. J., Tang, M. L. K., Collier, F., Carlin, J. B., Saffery, R., Burgner, D., Ranganathan, S., Dwyer, T., Ward, A. C., Moreno‐Betancur, M., Clarke, M., Ponsonby, A. L., Vuillermin, P.

“…Background Ecological evidence suggests vitamin D insufficiency (VDI) due to lower ambient ultraviolet radiation (UVR) exposure may be a risk factor for…”
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Accelerated Epigenetic Aging in Peripheral Blood does not Predict Dementia Risk by Fransquet, P D, Lacaze, P, Saffery, R, Shah, R C, Vryer, R, Murray, A, Woods, R L, Ryan, J

“…There is strong evidence that epigenetic age acceleration is associated with increased risk of later-life diseases and all-cause mortality. However, there is…”
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The metabolic health of young men conceived using intracytoplasmic sperm injection by Catford, S R, Halliday, J, Lewis, S, O'Bryan, M K, Handelsman, D J, Hart, R J, McBain, J, Rombauts, L, Amor, D J, Saffery, R, McLachlan, R I

“…Is the metabolic health of men conceived using ICSI different to that of IVF and spontaneously conceived (SC) men? ICSI-conceived men aged 18-24 years,…”
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The skin barrier function gene SPINK5 is associated with challenge‐proven IgE‐mediated food allergy in infants by Ashley, S. E., Tan, H.‐T. T., Vuillermin, P., Dharmage, S. C., Tang, M. L. K., Koplin, J., Gurrin, L. C., Lowe, A., Lodge, C., Ponsonby, A.‐L., Molloy, J., Martin, P., Matheson, M. C., Saffery, R., Allen, K. J., Ellis, J. A., Martino, D.

“…Background A defective skin barrier is hypothesized to be an important route of sensitization to dietary antigens and may lead to food allergy in some…”
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The effects of maternal anxiety during pregnancy on IGF2/H19 methylation in cord blood by Mansell, T, Novakovic, B, Meyer, B, Rzehak, P, Vuillermin, P, Ponsonby, A-L, Collier, F, Burgner, D, Saffery, R, Ryan, J

“…Compelling evidence suggests that maternal mental health in pregnancy can influence fetal development. The imprinted genes, insulin-like growth factor 2 ( IGF2…”
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Functionally distinct roles for different miR-155 expression levels through contrasting effects on gene expression, in acute myeloid leukaemia by Narayan, N, Morenos, L, Phipson, B, Willis, S N, Brumatti, G, Eggers, S, Lalaoui, N, Brown, L M, Kosasih, H J, Bartolo, R C, Zhou, L, Catchpoole, D, Saffery, R, Oshlack, A, Goodall, G J, Ekert, P G

“…Enforced expression of microRNA-155 (miR-155) in myeloid cells has been shown to have both oncogenic or tumour-suppressor functions in acute myeloid leukaemia…”
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The role of genetics and environment in the rise of childhood food allergy by Tan, T. H.-T., Ellis, J. A., Saffery, R., Allen, K. J.

“…Summary Food allergy is a growing clinical and public health problem world‐wide. The rising incidence is occurring more rapidly than changes to the genome…”
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DNA methylation in childhood dental caries and hypomineralization by MJ, Silva, N, Mohandas, JM, Craig, DJ, Manton, R, Saffery, MC, Southey, DP, Burgner, J, Lucas, NM, Kilpatrick, JL, Hopper, KJ, Scurrah, S, Li

“…Objectives: Epigenetic modulation of gene expression may be important in dental conditions, including dental caries and enamel hypomineralisation. The aims of…”
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The association between higher maternal pre‐pregnancy body mass index and increased birth weight, adiposity and inflammation in the newborn by McCloskey, K., Ponsonby, A.‐L., Collier, F., Allen, K., Tang, M. L.K., Carlin, J. B., Saffery, R., Skilton, M. R., Cheung, M., Ranganathan, S., Dwyer, T., Burgner, D., Vuillermin, P.

“…Summary Background Excess adiposity and adiposity‐related inflammation are known risk factors for cardiovascular disease in adults; however, little is known…”
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Wheel running and environmental enrichment differentially modify exon-specific BDNF expression in the hippocampus of wild-type and pre-motor symptomatic male and female Huntington's disease mice by Zajac, M.S., Pang, T.Y.C., Wong, N., Weinrich, B., Leang, L.S.K., Craig, J.M., Saffery, R., Hannan, A.J.

“…Brain‐derived neurotrophic factor (BDNF) is an essential neurotrophin and regulation of its expression is complex due to multiple 5′ untranslated exons which…”
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The potential for epigenetic analysis of paediatric CNS tumours to improve diagnosis, treatment and prognosis by Sexton-Oates, A., MacGregor, D., Dodgshun, A., Saffery, R.

“…Tumours of central nervous system (CNS) origin are the second most prevalent group of cancers in children, yet account for the majority of childhood…”
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Assessment of an AI-based tool for population-wide collection of placental morphological data by Camm, E.J., Wong, G., Pan, Y., Wang, J.Z., Goldstein, J.A., Arcot, A., Murphy, C.N., Hansji, H., Mangwiro, Y.T., Saffery, R., Wlodek, M.E., Wyrwoll, C.S., Gernand, A.D., Kaitu’u-Lino, T.J.

“…•A novel AI tool for automated placental assessment using photos was examined.•Modest effects of time and user on measures of placental size were…”
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A twin study of body mass index and dental caries in childhood by Silva, M. J., Kilpatrick, N. M., Craig, J. M., Manton, D. J., Leong, P., Ho, H., Saffery, R., Burgner, D. P., Scurrah, K. J.

“…Sub-optimal nutrition and dental caries are both common with significant short and long-term implications for child health and development. We applied twin…”
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Genomewide association study of peanut allergy reproduces association with amino acid polymorphisms in HLA‐DRB1 by Martino, D. J., Ashley, S., Koplin, J., Ellis, J., Saffery, R., Dharmage, S. C., Gurrin, L., Matheson, M. C., Kalb, B., Marenholz, I., Beyer, K., Lee, Y.‐A., Hong, X., Wang, X., Vukcevic, D., Motyer, A., Leslie, S., Allen, K. J., Ferreira, M. A. R.

“…Summary Background Genetic variants for IgE‐mediated peanut allergy are yet to be fully characterized and to date only one genomewide association study (GWAS)…”
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Genetic variation at the Th2 immune gene IL13 is associated with IgE‐mediated paediatric food allergy by Ashley, S. E., Tan, H.‐T. T., Peters, R., Allen, K. J., Vuillermin, P., Dharmage, S. C., Tang, M. L. K., Koplin, J., Lowe, A., Ponsonby, A.‐L., Molloy, J., Matheson, M. C., Saffery, R., Ellis, J. A., Martino, D.

“…Summary Background Food allergies pose a considerable world‐wide public health burden with incidence as high as one in ten in 12‐month‐old infants. Few food…”
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Prospects for epigenetic research within cohort studies of psychological disorder: A pilot investigation of a peripheral cell marker of epigenetic risk for depression by Olsson, C.A., Foley, D.L., Parkinson-Bates, M., Byrnes, G., McKenzie, M., Patton, G.C., Morley, R., Anney, R.J.L., Craig, J.M., Saffery, R.

“…Cohort studies have considerable prima facie value for investigating epigenetic processes in psychological disorder; however, the future prospects for such…”
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Maternal low glycemic index dietary intervention and DNA methylation in 5 year old offspring: results from the ROLO Kids Study by Geraghty, A.A., Sexton-Oates, A., O'Brien, E.C., Saffery, R., McAuliffe, F.M.

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DNA methylation of amino acid transporter genes in the human placenta by Simner, C., Novakovic, B., Lillycrop, K.A., Bell, C.G., Harvey, N.C., Cooper, C., Saffery, R., Lewis, R.M., Cleal, J.K.

“…Placental transfer of amino acids via amino acid transporters is essential for fetal growth. Little is known about the epigenetic regulation of amino acid…”
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