Search Results - "Saez, Lino"

Drosophila TIM binds importin α1, and acts as an adapter to transport PER to the nucleus by Jang, A Reum, Moravcevic, Katarina, Saez, Lino, Young, Michael W, Sehgal, Amita

“…Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA…”
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Studying circadian rhythm and sleep using genetic screens in Drosophila by Axelrod, Sofia, Saez, Lino, Young, Michael W

“…The power of Drosophila melanogaster as a model organism lies in its ability to be used for large-scale genetic screens with the capacity to uncover the…”
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Integration of light and temperature in the regulation of circadian gene expression in Drosophila by Boothroyd, Catharine E, Wijnen, Herman, Naef, Felix, Saez, Lino, Young, Michael W

“…Circadian clocks are aligned to the environment via synchronizing signals, or Zeitgebers, such as daily light and temperature cycles, food availability, and…”
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Activating PER repressor through a DBT-directed phosphorylation switch by Kivimäe, Saul, Saez, Lino, Young, Michael W

“…Protein phosphorylation plays an essential role in the generation of circadian rhythms, regulating the stability, activity, and subcellular localization of…”
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GSK-3 and CK2 Kinases Converge on Timeless to Regulate the Master Clock by Top, Deniz, Harms, Emily, Syed, Sheyum, Adams, Eliza L., Saez, Lino

“…The molecular clock relies on a delayed negative feedback loop of transcriptional regulation to generate oscillating gene expression. Although the principal…”
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Posttranscriptional and Posttranslational Regulation of Clock Genes by Harms, Emily, Kivimäe, Saul, Young, Michael W., Saez, Lino

“…Circadian rhythms have been observed in diverse organisms, including plants, animals, bacteria, and fungi. In such organisms, the circadian clock is primarily…”
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Post-translational enzyme activation in an animal via optimized conditional protein splicing by Muir, Tom W, Schwartz, Edmund C, Saez, Lino, Young, Michael W

“…Control over the timing, location and level of protein activity in vivo is crucial to understanding biological function. Living systems are able to respond to…”
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Phosphorylation of PERIOD Is Influenced by Cycling Physical Associations of DOUBLE-TIME, PERIOD, and TIMELESS in the Drosophila Clock by Kloss, Brian, Rothenfluh, Adrian, Young, Michael W, Saez, Lino

“…The clock gene double-time ( dbt) encodes an ortholog of casein kinase Iϵ that promotes phosphorylation and turnover of the PERIOD protein. Whereas the period…”
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Regulation of Nuclear Entry of the Drosophila Clock Proteins Period and Timeless by Saez, Lino, Young, Michael W

“…Two genesperiod (per) and timeless (tim), are essential for circadian rhythmicity in Drosophila. The encoded proteins (PER and TIM) physically interact. Here,…”
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Circadian phenotypes of Drosophila fragile x mutants in alternative genetic backgrounds by Sekine, Tatsumori, Yamaguchi, Terumi, Hamano, Kunikatsu, Siomi, Haruhiko, Saez, Lino, Ishida, Norio, Shimoda, Masami

“…Drosophila FMR1 mutants are models of human fragile X syndrome. They show a loss of locomotor activity rhythm and severe degradation of eclosion timing. We…”
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Notch Responds Differently to Delta and Wingless in CulturedDrosophila Cells by Wesley, Cedric S., Saez, Lino

“…Notch, a cell surface receptor, is required for producing different types of cells during development ofDrosophila melanogaster. Notch activates expression of…”
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Kinetics of Doubletime Kinase-dependent Degradation of the Drosophila Period Protein by Syed, Sheyum, Saez, Lino, Young, Michael W.

“…Robust circadian oscillations of the proteins PERIOD (PER) and TIMELESS (TIM) are hallmarks of a functional clock in the fruit fly Drosophila melanogaster…”
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PER-TIM Interactions in Living Drosophila Cells: An Interval Timer for the Circadian Clock by Meyer, Pablo, Saez, Lino, Young, Michael W

“…In contrast to current models, fluorescence resonance energy transfer measurements using a single-cell imaging assay with fluorescent forms of PER and TIM…”
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Drosophila TIM binds importin [alpha]1, and acts as an adapter to transport PER to the nucleus by Jang, A. Reum, Moravcevic, Katarina, Saez, Lino, Young, Michael W, Sehgal, Amita

“…Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA…”
Get full text

Drosophila TIM Binds Importin [alpha]1, and Acts as an Adapter to Transport PER to the Nucleus: e1004974 by Jang, A Reum, Moravcevic, Katarina, Saez, Lino, Young, Michael W, Sehgal, Amita

“…Regulated nuclear entry of clock proteins is a conserved feature of eukaryotic circadian clocks and serves to separate the phase of mRNA activation from mRNA…”
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A key temporal delay in the circadian cycle of Drosophila is mediated by a nuclear localization signal in the timeless protein by Saez, Lino, Derasmo, Mary, Meyer, Pablo, Stieglitz, J, Young, Michael W

“…Regulated nuclear entry of the Period (PER) and Timeless (TIM) proteins, two components of the Drosophila circadian clock, is essential for the generation and…”
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The Double-Time Protein Kinase Regulates the Subcellular Localization of the Drosophila Clock Protein Period by Cyran, Shawn A, Yiannoulos, Georgia, Buchsbaum, Anna M, Saez, Lino, Young, Michael W, Blau, Justin

“…The Period (PER), Timeless (TIM), and Double-Time (DBT) proteins are essential components of one feedback loop in the Drosophila circadian molecular clock. PER…”
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The Drosophila Clock Gene double-time Encodes a Protein Closely Related to Human Casein Kinase Iε by Kloss, Brian, Price, Jeffrey L, Saez, Lino, Blau, Justin, Rothenfluh, Adrian, Wesley, Cedric S, Young, Michael W

“…The cloning of double-time ( dbt) is reported. DOUBLETIME protein (DBT) is most closely related to human casein kinase Iε. dbt S and dbt L mutations, which…”
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A TIMELESS-Independent Function for PERIOD Proteins in the Drosophila Clock by Rothenfluh, Adrian, Young, Michael W., Saez, Lino

“…The mutation timeless UL generates 33 hr rhythms, prolonged nuclear localization of PERIOD/TIMELESS UL protein complexes, and protracted derepression of period…”
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Mammalian circadian autoregulatory loop: a timeless ortholog and mPer1 interact and negatively regulate CLOCK-BMAL1-induced transcription by Sangoram, A M, Saez, L, Antoch, M P, Gekakis, N, Staknis, D, Whiteley, A, Fruechte, E M, Vitaterna, M H, Shimomura, K, King, D P, Young, M W, Weitz, C J, Takahashi, J S

“…We report the cloning and mapping of mouse (mTim) and human (hTIM) orthologs of the Drosophila timeless (dtim) gene. The mammalian Tim genes are widely…”
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