Search Results - "Saez, Borja"

Selective hematopoietic stem cell ablation using CD117-antibody-drug-conjugates enables safe and effective transplantation with immunity preservation by Czechowicz, Agnieszka, Palchaudhuri, Rahul, Scheck, Amelia, Hu, Yu, Hoggatt, Jonathan, Saez, Borja, Pang, Wendy W., Mansour, Michael K., Tate, Tiffany A., Chan, Yan Yi, Walck, Emily, Wernig, Gerlinde, Shizuru, Judith A., Winau, Florian, Scadden, David T., Rossi, Derrick J.

“…Hematopoietic stem cell transplantation (HSCT) is a curative therapy for blood and immune diseases with potential for many settings beyond current…”
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Functions of Replication Protein A as a Sensor of R Loops and a Regulator of RNaseH1 by Nguyen, Hai Dang, Yadav, Tribhuwan, Giri, Sumanprava, Saez, Borja, Graubert, Timothy A., Zou, Lee

“…R loop, a transcription intermediate containing RNA:DNA hybrids and displaced single-stranded DNA (ssDNA), has emerged as a major source of genomic…”
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Splicing factor gene mutations in hematologic malignancies by Saez, Borja, Walter, Matthew J., Graubert, Timothy A.

“…Alternative splicing generates a diversity of messenger RNA (mRNA) transcripts from a single mRNA precursor and contributes to the complexity of our proteome…”
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The Lkb1 metabolic sensor maintains haematopoietic stem cell survival by Scadden, David T, Bardeesy, Nabeel, Gurumurthy, Sushma, Xie, Stephanie Z, Alagesan, Brinda, Kim, Judith, Yusuf, Rushdia Z, Saez, Borja, Tzatsos, Alexandros, Ozsolak, Fatih, Milos, Patrice, Ferrari, Francesco, Park, Peter J, Shirihai, Orian S

“…Haematopoietic stem cells (HSCs) can convert between growth states that have marked differences in bioenergetic needs. Although often quiescent in adults,…”
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Injury Induces Direct Lineage Segregation of Functionally Distinct Airway Basal Stem/Progenitor Cell Subpopulations by Pardo-Saganta, Ana, Law, Brandon M., Tata, Purushothama Rao, Villoria, Jorge, Saez, Borja, Mou, Hongmei, Zhao, Rui, Rajagopal, Jayaraj

“…Following injury, stem cells restore normal tissue architecture by producing the proper number and proportions of differentiated cells. Current models of…”
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Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin by Palchaudhuri, Rahul, Saez, Borja, Hoggatt, Jonathan, Schajnovitz, Amir, Sykes, David B, Tate, Tiffany A, Czechowicz, Agnieszka, Kfoury, Youmna, Ruchika, FNU, Rossi, Derrick J, Verdine, Gregory L, Mansour, Michael K, Scadden, David T

“…An antibody-based conditioning agent enables hematopoietic stem cell transplantation in immunocompetent mice with less toxicity than irradiation. Hematopoietic…”
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SIRT1 regulates differentiation of mesenchymal stem cells by deacetylating β‐catenin by Simic, Petra, Zainabadi, Kayvan, Bell, Eric, Sykes, David B., Saez, Borja, Lotinun, Sutada, Baron, Roland, Scadden, David, Schipani, Ernestina, Guarente, Leonard

“…Mesenchymal stem cells (MSCs) are multi‐potent cells that can differentiate into osteoblasts, adipocytes, chondrocytes and myocytes. This potential declines…”
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Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow by Yu, Vionnie W C, Saez, Borja, Cook, Colleen, Lotinun, Sutada, Pardo-Saganta, Ana, Wang, Ying-Hua, Lymperi, Stefania, Ferraro, Francesca, Raaijmakers, Marc H G P, Wu, Joy Y, Zhou, Lan, Rajagopal, Jayaraj, Kronenberg, Henry M, Baron, Roland, Scadden, David T

“…Production of the cells that ultimately populate the thymus to generate α/β T cells has been controversial, and their molecular drivers remain undefined. Here,…”
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Mutant U2AF1-expressing cells are sensitive to pharmacological modulation of the spliceosome by Shirai, Cara Lunn, White, Brian S., Tripathi, Manorama, Tapia, Roberto, Ley, James N., Ndonwi, Matthew, Kim, Sanghyun, Shao, Jin, Carver, Alexa, Saez, Borja, Fulton, Robert S., Fronick, Catrina, O’Laughlin, Michelle, Lagisetti, Chandraiah, Webb, Thomas R., Graubert, Timothy A., Walter, Matthew J.

“…Somatic mutations in spliceosome genes are detectable in ∼50% of patients with myelodysplastic syndromes (MDS). We hypothesize that cells harbouring…”
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Diabetes impairs hematopoietic stem cell mobilization by altering niche function by Ferraro, Francesca, Lymperi, Stefania, Méndez-Ferrer, Simón, Saez, Borja, Spencer, Joel A, Yeap, Beow Y, Masselli, Elena, Graiani, Gallia, Prezioso, Lucia, Rizzini, Elisa Lodi, Mangoni, Marcellina, Rizzoli, Vittorio, Sykes, Stephen M, Lin, Charles P, Frenette, Paul S, Quaini, Federico, Scadden, David T

“…Success with transplantation of autologous hematopoietic stem and progenitor cells (HSPCs) in patients depends on adequate collection of these cells after…”
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Promises and Challenges of Cell-Based Therapies to Promote Lung Regeneration in Idiopathic Pulmonary Fibrosis by Egea-Zorrilla, Alejandro, Vera, Laura, Saez, Borja, Pardo-Saganta, Ana

“…The lung epithelium is constantly exposed to harmful agents present in the air that we breathe making it highly susceptible to damage. However, in instances of…”
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Tle1 tumor suppressor negatively regulates inflammation in vivo and modulates NF-κB inflammatory pathway by Ramasamy, Selvi, Saez, Borja, Mukhopadhyay, Subhankar, Ding, Daching, Ahmed, Alwiya M., Chen, Xi, Pucci, Ferdinando, Yamin, Rae’e, Wang, Jianfeng, Pittet, Mikael J., Kelleher, Cassandra M., Scadden, David T., Sweetser, David A.

“…Tle1 (transducin-like enhancer of split 1) is a corepressor that interacts with a variety of DNA-binding transcription factors and has been implicated in many…”
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Characterization of freshly isolated bone marrow mesenchymal stromal cells from healthy donors and patients with multiple myeloma: transcriptional modulation of the microenvironment by Alameda, Daniel, Saez, Borja, Lara-Astiaso, David, Sarvide, Sarai, Lasa, Marta, Alignani, Diego, Rodriguez, Idoia, Garate, Sonia, Vilas, Amaia, Paiva, Bruno, Alfonso-Olmos, Matias, De Espinosa, Jose Maria Lamo, Prosper, Felipe, Miguel, Jesus F San, Maiso, Patricia

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Gesture Recognition With Ultrasounds and Edge Computing by Saez, Borja, Mendez, Javier, Molina, Miguel, Castillo, Encarnacion, Pegalajar, Manuel, Morales, Diego P.

“…The aim of this work is to prove that it is possible to develop a system able to detect gestures based only on ultrasonic signals and Edge devices. A set of 7…”
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Down-Regulation of hsa-miR-10a in Chronic Myeloid Leukemia CD34+ Cells Increases USF2-Mediated Cell Growth by Agirre, Xabier, Jiménez-Velasco, Antonio, San José-Enériz, Edurne, Garate, Leire, Bandrés, Eva, Cordeu, Lucia, Aparicio, Oscar, Saez, Borja, Navarro, Germán, Vilas-Zornoza, Amaia, Pérez-Roger, Ignacio, García-Foncillas, Jesús, Torres, Antonio, Heiniger, Anabel, Calasanz, María José, Fortes, Puri, Román-Gómez, José, Prósper, Felipe

“…MicroRNAs (miRNA) are small noncoding, single-stranded RNAs that inhibit gene expression at a posttranscriptional level, whose abnormal expression has been…”
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Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning by Saez, Borja, Ferraro, Francesca, Yusuf, Rushdia Z., Cook, Colleen M., Yu, Vionnie W.C., Pardo-Saganta, Ana, Sykes, Stephen M., Palchaudhuri, Rahul, Schajnovitz, Amir, Lotinun, Sutada, Lymperi, Stefania, Mendez-Ferrer, Simon, Toro, Raquel del, Day, Robyn, Vasic, Radovan, Acharya, Sanket S., Baron, Roland, Lin, Charles P., Yamaguchi, Yu, Wagers, Amy J., Scadden, David T.

“…The glycosyltransferase gene, Ext1, is essential for heparan sulfate production. Induced deletion of Ext1 selectively in Mx1-expressing bone marrow (BM)…”
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Air-Writing Character Recognition with Ultrasonic Transceivers by Saez-Mingorance, Borja, Mendez-Gomez, Javier, Mauro, Gianfranco, Castillo-Morales, Encarnacion, Pegalajar-Cuellar, Manuel, Morales-Santos, Diego P.

“…The interfaces between users and systems are evolving into a more natural communication, including user gestures as part of the interaction, where air-writing…”
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Epigenetic Memory Underlies Cell-Autonomous Heterogeneous Behavior of Hematopoietic Stem Cells by Yu, Vionnie W.C., Yusuf, Rushdia Z., Oki, Toshihiko, Wu, Juwell, Saez, Borja, Wang, Xin, Cook, Colleen, Baryawno, Ninib, Ziller, Michael J., Lee, Eunjung, Gu, Hongcang, Meissner, Alexander, Lin, Charles P., Kharchenko, Peter V., Scadden, David T.

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Object Positioning Algorithm Based on Multidimensional Scaling and Optimization for Synthetic Gesture Data Generation by Saez-Mingorance, Borja, Escobar-Molero, Antonio, Mendez-Gomez, Javier, Castillo-Morales, Encarnacion, Morales-Santos, Diego P.

“…This work studies the feasibility of a novel two-step algorithm for infrastructure and object positioning, using pairwise distances. The proposal is based on…”
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Deconvolution of the hematopoietic stem cell microenvironment reveals a high degree of specialization and conservation by Ye, Jin, Calvo, Isabel A., Cenzano, Itziar, Vilas, Amaia, Martinez-de-Morentin, Xabier, Lasaga, Miren, Alignani, Diego, Paiva, Bruno, Viñado, Ana C., San Martin-Uriz, Patxi, Romero, Juan P., Quilez Agreda, Delia, Miñana Barrios, Marta, Sancho-González, Ignacio, Todisco, Gabriele, Malcovati, Luca, Planell, Nuria, Saez, Borja, Tegner, Jesper N., Prosper, Felipe, Gomez-Cabrero, David

“…Understanding the regulation of normal and malignant human hematopoiesis requires comprehensive cell atlas of the hematopoietic stem cell (HSC) regulatory…”
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