Search Results - "Saez, Ana"

Pore formation in regulated cell death by Flores‐Romero, Hector, Ros, Uris, Garcia‐Saez, Ana J

“…The discovery of alternative signaling pathways that regulate cell death has revealed multiple strategies for promoting cell death with diverse consequences at…”
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Mechanisms of BCL-2 family proteins in mitochondrial apoptosis by Czabotar, Peter E., Garcia-Saez, Ana J.

“…The proteins of the BCL-2 family are key regulators of mitochondrial apoptosis, acting as either promoters or inhibitors of cell death. The functional…”
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BCL‐2‐family protein tBID can act as a BAX‐like effector of apoptosis by Flores‐Romero, Hector, Hohorst, Lisa, John, Malina, Albert, Marie‐Christine, King, Louise E, Beckmann, Laura, Szabo, Tamas, Hertlein, Vanessa, Luo, Xu, Villunger, Andreas, Frenzel, Lukas P, Kashkar, Hamid, Garcia‐Saez, Ana J

“…During apoptosis, the BCL‐2‐family protein tBID promotes mitochondrial permeabilization by activating BAX and BAK and by blocking anti‐apoptotic BCL‐2 members…”
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DRP1 interacts directly with BAX to induce its activation and apoptosis by Jenner, Andreas, Peña‐Blanco, Aida, Salvador‐Gallego, Raquel, Ugarte‐Uribe, Begoña, Zollo, Cristiana, Ganief, Tariq, Bierlmeier, Jan, Mund, Markus, Lee, Jason E, Ries, Jonas, Schwarzer, Dirk, Macek, Boris, Garcia‐Saez, Ana J

“…The apoptotic executioner protein BAX and the dynamin‐like protein DRP1 co‐localize at mitochondria during apoptosis to mediate mitochondrial permeabilization…”
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Dying in self-defense: cell death signaling in animals and plants by Garcia-Saez, Ana J.

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Mitochondrial permeabilization in apoptosis: Advanced microscopy approaches by Garcia-Saez, Ana J.

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Quaternary structure of a G-protein-coupled receptor heterotetramer in complex with Gi and Gs by Navarro, Gemma, Cordomí, Arnau, Zelman-Femiak, Monika, Brugarolas, Marc, Moreno, Estefania, Aguinaga, David, Perez-Benito, Laura, Cortés, Antoni, Casadó, Vicent, Mallol, Josefa, Canela, Enric I, Lluís, Carme, Pardo, Leonardo, García-Sáez, Ana J, McCormick, Peter J, Franco, Rafael

“…G-protein-coupled receptors (GPCRs), in the form of monomers or homodimers that bind heterotrimeric G proteins, are fundamental in the transfer of…”
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The regulation of the apoptotic pore-An immunological tightrope walk by Jenner, Andreas, Garcia-Saez, Ana J

“…Apoptotic pore formation in mitochondria is the pivotal point for cell death during mitochondrial apoptosis. It is regulated by BCL-2 family proteins in…”
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The interplay between BAX and BAK tunes apoptotic pore growth to control mitochondrial-DNA-mediated inflammation by Cosentino, Katia, Hertlein, Vanessa, Jenner, Andreas, Dellmann, Timo, Gojkovic, Milos, Peña-Blanco, Aida, Dadsena, Shashank, Wajngarten, Noel, Danial, John S.H., Thevathasan, Jervis Vermal, Mund, Markus, Ries, Jonas, Garcia-Saez, Ana J.

“…BAX and BAK are key apoptosis regulators that mediate the decisive step of mitochondrial outer membrane permeabilization. However, the mechanism by which they…”
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Structural Insights into Polymer-Bounded Lipid Nanodiscs by Maier, Ralph, Cuevas Arenas, Rodrigo, Zhang, Fajun, García-Sáez, Ana, Schreiber, Frank

“…Membrane proteins are an essential part of signaling and transport processes and are targeted by multiple drugs. To isolate and investigate them in their…”
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Visualization of BOK pores independent of BAX and BAK reveals a similar mechanism with differing regulation by Shalaby, Raed, Diwan, Arzoo, Flores-Romero, Hector, Hertlein, Vanessa, Garcia-Saez, Ana J.

“…BOK is a poorly understood member of the BCL-2 family of proteins that has been proposed to function as a pro-apoptotic, BAX-like effector. However, the…”
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Super-resolution microscopy methods to study membrane pores in situ by Dellmann, Timo, Shalaby, Raed, Garcia-Saez, Ana J

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Partners in Crime: The Interplay of Proteins and Membranes in Regulated Necrosis by Ros, Uris, Pedrera, Lohans, Garcia-Saez, Ana J

“…Pyroptosis, necroptosis, and ferroptosis are well-characterized forms of regulated necrosis that have been associated with human diseases. During regulated…”
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The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID by Fernández‐Marrero, Yuniel, Bleicken, Stephanie, Das, Kushal Kumar, Bachmann, Daniel, Kaufmann, Thomas, Garcia‐Saez, Ana J.

“…The BCL‐2 family members are key regulators of the intrinsic apoptotic pathway, which is defined by permeabilization of the mitochondrial outer membrane by…”
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Quantitative analysis of super-resolved structures using ASAP by Danial, John S. H., Garcia-Saez, Ana J.

“…Super-resolution microscopy allows imaging of cellular structures with high throughput and detail. However, the efficient and quantitative analysis of images…”
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Dynein light chain binding determines complex formation and posttranslational stability of the Bcl-2 family members Bmf and Bim by Singh, Prafull Kumar, Roukounakis, Aristomenis, Weber, Arnim, Das, Kushal Kumar, Sohm, Benedicte, Villunger, Andreas, Garcia-Saez, Ana J., Häcker, Georg

“…The BH3-only class of Bcl-2 family proteins triggers mitochondrial apoptosis. Several mechanisms are used to restrain the pro-apoptotic activity of these…”
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An industrial case study on the use of UML in software maintenance and its perceived benefits and hurdles by Fernández-Sáez, Ana M., Chaudron, Michel R. V., Genero, Marcela

“…UML is a commonly-used graphical language for the modelling of software. Works regarding UML’s effectiveness have studied projects that develop software…”
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Techniques for studying membrane pores by Ros, Uris, Pedrera, Lohans, Garcia-Saez, Ana J.

“…Pore-forming proteins (PFPs) are of special interest because of the association of their activity with the disruption of the membrane impermeability barrier…”
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Mitochondrial residence of the apoptosis inducer BAX is more important than BAX oligomerization in promoting membrane permeabilization by Kuwana, Tomomi, King, Louise E., Cosentino, Katia, Suess, Julian, Garcia-Saez, Ana J., Gilmore, Andrew P., Newmeyer, Donald D.

“…Permeabilization of the mitochondrial outer membrane is a key step in the intrinsic apoptosis pathway, triggered by the release of mitochondrial intermembrane…”
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Quantitative interactome of a membrane Bcl-2 network identifies a hierarchy of complexes for apoptosis regulation by Bleicken, Stephanie, Hantusch, Annika, Das, Kushal Kumar, Frickey, Tancred, Garcia-Saez, Ana J.

“…The Bcl-2 proteins form a complex interaction network that controls mitochondrial permeabilization and apoptosis. The relative importance of different Bcl-2…”
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