Search Results - "Saenz, Dyana T."

RUNX1-targeted therapy for AML expressing somatic or germline mutation in RUNX1 by Mill, Christopher P., Fiskus, Warren, DiNardo, Courtney D., Qian, Yimin, Raina, Kanak, Rajapakshe, Kimal, Perera, Dimuthu, Coarfa, Cristian, Kadia, Tapan M., Khoury, Joseph D., Saenz, Dyana T., Saenz, David N., Illendula, Anuradha, Takahashi, Koichi, Kornblau, Steven M., Green, Michael R., Futreal, Andrew P., Bushweller, John H., Crews, Craig M., Bhalla, Kapil N.

“…RUNX1 transcription factor regulates normal and malignant hematopoiesis. Somatic or germline mutant RUNX1 (mtRUNX1) is associated with poorer outcome in acute…”
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Synergistic activity of BET protein antagonist-based combinations in mantle cell lymphoma cells sensitive or resistant to ibrutinib by Sun, Baohua, Shah, Bhavin, Fiskus, Warren, Qi, Jun, Rajapakshe, Kimal, Coarfa, Cristian, Li, Li, Devaraj, Santhana G.T., Sharma, Sunil, Zhang, Liang, Wang, Michael L., Saenz, Dyana T., Krieger, Stephanie, Bradner, James E., Bhalla, Kapil N.

“…Mantle cell lymphoma (MCL) cells exhibit increased B-cell receptor and nuclear factor (NF)-κB activities. The bromodomain and extra-terminal (BET) protein…”
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Essential Role for LEDGF/p75 in HIV Integration by Llano, Manuel, Saenz, Dyana T, Meehan, Anne, Wongthida, Phonphimon, Peretz, Mary, Walker, William H, Teo, Wulin, Poeschla, Eric M

“…Chromosomal integration enables human immunodeficiency virus (HIV) to establish a permanent reservoir that can be therapeutically suppressed but not…”
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A cyclophilin homology domain-independent role for Nup358 in HIV-1 infection by Meehan, Anne M, Saenz, Dyana T, Guevera, Rebekah, Morrison, James H, Peretz, Mary, Fadel, Hind J, Hamada, Masakazu, van Deursen, Jan, Poeschla, Eric M

“…The large nucleoporin Nup358/RanBP2 forms eight filaments that project from the nuclear pore into the cytoplasm where they function as docking platforms for…”
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Feline Immunodeficiency Virus Envelope Glycoproteins Antagonize Tetherin through a Distinctive Mechanism That Requires Virion Incorporation by Morrison, James H, Guevara, Rebekah B, Marcano, Adriana C, Saenz, Dyana T, Fadel, Hind J, Rogstad, Daniel K, Poeschla, Eric M

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Improving awareness of several combination therapies for acute myeloid leukemia among oncology and hematology team members in Colorado, USA by Ismailov, Rovshan M, Saenz, Dyana T, Gascon, Pere, Nucci, Marcio, Khasanova, Zaytuna D

“…Although several combination therapies for acute myeloid leukemia (AML) have emerged recently, there has been a lack of published surveys and educational…”
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The HIV-1 Central Polypurine Tract Functions as a Second Line of Defense against APOBEC3G/F by Hu, Chunling, Saenz, Dyana T, Fadel, Hind J, Walker, William, Peretz, Mary, Poeschla, Eric M

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LEDGF Dominant Interference Proteins Demonstrate Prenuclear Exposure of HIV-1 Integrase and Synergize with LEDGF Depletion To Destroy Viral Infectivity by MEEHAN, Anne M, SAENZ, Dyana T, MORRISON, James, CHUNLING HU, PERETZ, Mary, POESCHLA, Eric M

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LEDGF/p75 proteins with alternative chromatin tethers are functional HIV-1 cofactors by Meehan, Anne M, Saenz, Dyana T, Morrison, James H, Garcia-Rivera, Jose A, Peretz, Mary, Llano, Manuel, Poeschla, Eric M

“…LEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this underlies its integration cofactor role for these retroviruses is…”
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The HIV-1-Specific Protein Casp8p41 Induces Death of Infected Cells through Bax/Bak by SAINSKI, Amy M, NATESAMPILLAI, Sekar, CUMMINS, Nathan W, BREN, Gary D, TAYLOR, Julie, SAENZ, Dyana T, POESCHLA, Eric M, BADLEY, Andrew D

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Productive Replication of vif-Chimeric HIV-1 in Feline Cells by Stern, Melissa A, Hu, Chunling, Saenz, Dyana T, Fadel, Hind J, Sims, Olivia, Peretz, Mary, Poeschla, Eric M

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High-throughput screening for growth inhibitors using a yeast model of familial paraganglioma by Bancos, Irina, Bida, John Paul, Tian, Defeng, Bundrick, Mary, John, Kristen, Holte, Molly Nelson, Her, Yeng F, Evans, Debra, Saenz, Dyana T, Poeschla, Eric M, Hook, Derek, Georg, Gunda, Maher, 3rd, L James

“…Classical tumor suppressor genes block neoplasia by regulating cell growth and death. A remarkable puzzle is therefore presented by familial paraganglioma…”
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Restriction of Feline Immunodeficiency Virus by Ref1, Lv1, and Primate TRIM5α Proteins by SAENZ, Dyana T, TEO, Wulin, OLSEN, John C, POESCHLA, Eric M

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Productive Replication and Evolution of HIV-1 in Ferret Cells by FADEL, Hind J, SAENZ, Dyana T, GUEVARA, Rebekah, VON MESSLING, Veronika, PERETZ, Mary, POESCHLA, Eric M

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Unintegrated Lentivirus DNA Persistence and Accessibility to Expression in Nondividing Cells: Analysis with Class I Integrase Mutants by SAENZ, Dyana T, LOEWEN, Nils, PERETZ, Mary, WHITWAM, Todd, BARRAZA, Roman, HOWELL, Kyle G, HOLMES, Jonathan M, GOOD, Margaret, POESCHLA, Eric M

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TALEN knockout of the PSIP1 gene in human cells: analyses of HIV-1 replication and allosteric integrase inhibitor mechanism by Fadel, Hind J, Morrison, James H, Saenz, Dyana T, Fuchs, James R, Kvaratskhelia, Mamuka, Ekker, Stephen C, Poeschla, Eric M

“…HIV-1 utilizes the cellular protein LEDGF/p75 as a chromosome docking and integration cofactor. The LEDGF/p75 gene, PSIP1, is a potential therapeutic target…”
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SIRT2 Deacetylates and Inhibits the Peroxidase Activity of Peroxiredoxin-1 to Sensitize Breast Cancer Cells to Oxidant Stress-Inducing Agents by Fiskus, Warren, Coothankandaswamy, Veena, Chen, Jianguang, Ma, Hongwei, Ha, Kyungsoo, Saenz, Dyana T, Krieger, Stephanie S, Mill, Christopher P, Sun, Baohua, Huang, Peng, Mumm, Jeffrey S, Melnick, Ari M, Bhalla, Kapil N

“…SIRT2 is a protein deacetylase with tumor suppressor activity in breast and liver tumors where it is mutated; however, the critical substrates mediating its…”
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BET protein bromodomain inhibitor-based combinations are highly active against post-myeloproliferative neoplasm secondary AML cells by Saenz, D T, Fiskus, W, Manshouri, T, Rajapakshe, K, Krieger, S, Sun, B, Mill, C P, DiNardo, C, Pemmaraju, N, Kadia, T, Parmar, S, Sharma, S, Coarfa, C, Qiu, P, Verstovsek, S, Bhalla, K N

“…Myeloproliferative neoplasms with myelofibrosis (MPN-MF) demonstrate constitutive activation of Janus kinase/signal transducer and activator of transcription…”
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BET proteolysis targeted chimera-based therapy of novel models of Richter Transformation-diffuse large B-cell lymphoma by Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Birdwell, Christine, Deng, Qing, Yang, Haopeng, Lara, Bernardo H., Jain, Nitin, Burger, Jan, Ferrajoli, Alessandra, Davis, John A., Saenz, Dyana T., Jin, Wendy, Coarfa, Cristian, Crews, Craig M., Green, Michael R., Khoury, Joseph D., Bhalla, Kapil N.

“…Richter Transformation (RT) develops in CLL as an aggressive, therapy-resistant, diffuse large B cell lymphoma (RT-DLBCL), commonly clonally-related (CLR) to…”
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Mechanistic basis and efficacy of targeting the β-catenin–TCF7L2–JMJD6–c-Myc axis to overcome resistance to BET inhibitors by Saenz, Dyana T., Fiskus, Warren, Mill, Christopher P., Perera, Dimuthu, Manshouri, Taghi, Lara, Bernardo H., Karkhanis, Vrajesh, Sharma, Sunil, Horrigan, Stephen K., Bose, Prithviraj, Kadia, Tapan M., Masarova, Lucia, DiNardo, Courtney D., Borthakur, Gautam, Khoury, Joseph D., Takahashi, Koichi, Bhaskara, Srividya, Lin, Charles Y., Green, Michael R., Coarfa, Cristian, Crews, Craig M., Verstovsek, Srdan, Bhalla, Kapil N.

“…The promising activity of BET protein inhibitors (BETi's) is compromised by adaptive or innate resistance in acute myeloid leukemia (AML). Here, modeling of…”
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