Search Results - "Saenger, Thorsten"

Structural and functional characterization of a putative de novo gene in Drosophila by Lange, Andreas, Patel, Prajal H., Heames, Brennen, Damry, Adam M., Saenger, Thorsten, Jackson, Colin J., Findlay, Geoffrey D., Bornberg-Bauer, Erich

“…Comparative genomic studies have repeatedly shown that new protein-coding genes can emerge de novo from noncoding DNA. Still unknown is how and when the…”
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Structural Analysis of Breast-Milk α S1 -Casein: An α-Helical Conformation Is Required for TLR4-Stimulation by Saenger, Thorsten, Schulte, Marten F, Vordenbäumen, Stefan, Hermann, Fabian C, Bertelsbeck, Juliana, Meier, Kathrin, Bleck, Ellen, Schneider, Matthias, Jose, Joachim

“…Breast-milk α -casein is a Toll-like receptor 4 (TLR4) agonist, whereas phosphorylated α -casein does not bind TLR4. The objective of this study was to analyse…”
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Root Extracts From Ononis spinosa Inhibit IL-8 Release via Interactions With Toll-Like Receptor 4 and Lipopolysaccharide by Spiegler, Verena, Gierlikowska, Barbara, Saenger, Thorsten, Addotey, John N., Sendker, Jandirk, Jose, Joachim, Kiss, Anna K., Hensel, Andreas

“…Extracts from the roots of Ononis spinosa L. (restharrow roots) are traditionally used for the treatment of patients with urinary tract infections due to its…”
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Site-Specific Labeling of Protein Kinase CK2: Combining Surface Display and Click Chemistry for Drug Discovery Applications by Nienberg, Christian, Retterath, Anika, Becher, Kira-Sophie, Saenger, Thorsten, Mootz, Henning D, Jose, Joachim

“…Human CK2 is a heterotetrameric constitutively active serine/threonine protein kinase and is an emerging target in current anti-cancer drug discovery. The…”
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Autoantibodies to αS1-casein are induced by breast-feeding by Petermann, Klaudia, Vordenbäumen, Stefan, Maas, Ruth, Braukmann, Achim, Bleck, Ellen, Saenger, Thorsten, Schneider, Matthias, Jose, Joachim

“…The generation of antibodies is impaired in newborns due to an immature immune system and reduced exposure to pathogens due to maternally derived antibodies…”
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Structural Analysis of Breast-Milk α[sub.S1]-Casein: An α-Helical Conformation Is Required for TLR4-Stimulation by Saenger, Thorsten, Schulte, Marten F, Vordenbäumen, Stefan, Hermann, Fabian C, Bertelsbeck, Juliana, Meier, Kathrin, Bleck, Ellen, Schneider, Matthias, Jose, Joachim

“…Breast-milk α[sub.S1]-casein is a Toll-like receptor 4 (TLR4) agonist, whereas phosphorylated α[sub.S1]-casein does not bind TLR4. The objective of this study…”
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Human αS1-casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex by Saenger, Thorsten, Vordenbäumen, Stefan, Genich, Swetlana, Haidar, Samer, Schulte, Marten, Nienberg, Christian, Bleck, Ellen, Schneider, Matthias, Jose, Joachim

“…The milk protein αS1-casein was recently reported to induce secretion of proinflammatory cytokines via Toll-like receptor 4 (TLR4). In this study, αS1-casein…”
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State-of-the-Art Meeting on Sex and Gender in Transplantation: The Female Perspective by Sugianto, Rizky Indrameikha, Saenger, Thorsten, Ahn, Curie, Chong, Anita S., Goldberg, Aviva M., Grabitz, Carl, Mannon, Roslyn B., Marson, Lorna, Memaran, Nima, Sapir-Pichhadze, Ruth, Tullius, Stefan G., von der Born, Jeannine, West, Lori J., Foster, Bethany J., Lerminiaux, Louise, Wong, Germaine, Melk, Anette

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Human casein alpha s1 induces proinflammatory cytokine expression in monocytic cells by TLR4 signaling by Vordenbäumen, Stefan, Saenger, Thorsten, Braukmann, Achim, Tahan, Tamara, Bleck, Ellen, Jose, Joachim, Schneider, Matthias

“…Scope Human casein alpha S1 (CSN1S1) is a milk‐derived protein, which gives rise to sustained antibody formation after breast feeding in infancy and induces…”
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Ser71 of αS1‐Casein is Phosphorylated in Breast Milk—Evidence from Targeted Mass Analysis by König, Simone, Altendorfer, Irina, Saenger, Thorsten, Bleck, Ellen, Vordenbäumen, Stefan, Schneider, Matthias, Jose, Joachim

“…Scope The casein phosphoproteins in mother's milk supply calcium and phosphate ions and make them biologically available to the newborn. Human αS1‐casein is of…”
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Co-autodisplay of Z-domains and bovine caseins on the outer membrane of E. coli by Yoo, Gu, Saenger, Thorsten, Bong, Ji-Hong, Jose, Joachim, Kang, Min-Jung, Pyun, Jae-Chul

“…In this work, two proteins, Z-domains and bovine casein, were autodisplayed on the outer membrane of the same Escherichia coli cells by co-transformation of…”
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Quantification of αS1-casein in breast milk using a targeted mass spectrometry-based approach by Altendorfer, Irina, König, Simone, Braukmann, Achim, Saenger, Thorsten, Bleck, Ellen, Vordenbäumen, Stefan, Kubiak, Anna, Schneider, Matthias, Jose, Joachim

“…•A MS based method was developed to directly measure the αS1-casein (CSN1S1) content in breast milk.•Tryptic CSN1S1 digestion was coupled with liquid…”
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Development of a surface display ELISA to detect anti-IgG antibodies against bovine αS1-casein in human sera by Saenger, Thorsten, Braukmann, Achim, Vordenbäumen, Stefan, Altendorfer, Irina, Bleck, Ellen, Hochwallner, Heidrun, Valenta, Rudolf, Schneider, Matthias, Jose, Joachim

“…•A whole cell SD-ELISA to detect IgG antibodies against bovine CSN1S1 in human sera was developed.•SD-ELISA is quick and simple, but as sensitive as standard…”
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Development of a Countergradient Parking System for Gradient Liquid Chromatography with Online Biochemical Detection of Serine Protease Inhibitors by Schebb, Nils Helge, Heus, Ferry, Saenger, Thorsten, Karst, Uwe, Irth, Hubertus, Kool, Jeroen

“…A gradient HPLC approach in combination with a countergradient system for online biochemical detection (BCD) to screen for inhibitors of serine proteases is…”
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Autoantibodies to [alpha]S1-Casein Are Induced by Breast-Feeding by Petermann, Klaudia, Vordenbäumen, Stefan, Maas, Ruth, Braukmann, Achim, Bleck, Ellen, Saenger, Thorsten, Schneider, Matthias, Jose, Joachim

“…Background The generation of antibodies is impaired in newborns due to an immature immune system and reduced exposure to pathogens due to maternally derived…”
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Human α S1 -casein induces IL-8 secretion by binding to the ecto-domain of the TLR4/MD2 receptor complex by Saenger, Thorsten, Vordenbäumen, Stefan, Genich, Swetlana, Haidar, Samer, Schulte, Marten, Nienberg, Christian, Bleck, Ellen, Schneider, Matthias, Jose, Joachim

“…The milk protein α -casein was recently reported to induce secretion of proinflammatory cytokines via Toll-like receptor 4 (TLR4). In this study, α -casein was…”
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