Search Results - "Saeland, Eirikur"

Adenoviral vector type 26 encoding Zika virus (ZIKV) M-Env antigen induces humoral and cellular immune responses and protects mice and nonhuman primates against ZIKV challenge by Cox, Freek, van der Fits, Leslie, Abbink, Peter, Larocca, Rafael A, van Huizen, Ella, Saeland, Eirikur, Verhagen, Janneke, Peterson, Rebecca, Tolboom, Jeroen, Kaufmann, Baerbel, Schuitemaker, Hanneke, Barouch, Dan H, Zahn, Roland

“…In 2015, there was a large outbreak of Zika virus (ZIKV) in Brazil. Despite its relatively mild impact on healthy adults, ZIKV infection during pregnancy has…”
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Sweet preferences of MGL: carbohydrate specificity and function by van Vliet, Sandra J, Saeland, Eirikur, van Kooyk, Yvette

“…C-type lectins play important roles in both innate and adaptive immune responses. In contrast to the mannose- or fucose-specific C-type lectins DC-SIGN and…”
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Protection against H5N1 Influenza Virus Induced by Matrix-M Adjuvanted Seasonal Virosomal Vaccine in Mice Requires Both Antibodies and T Cells by Cox, Freek, Baart, Matthijs, Huizingh, Jeroen, Tolboom, Jeroen, Dekking, Liesbeth, Goudsmit, Jaap, Saeland, Eirikur, Radošević, Katarina

“…It remains important to develop the next generation of influenza vaccines that can provide protection against vaccine mismatched strains and to be prepared for…”
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The C-type lectin MGL expressed by dendritic cells detects glycan changes on MUC1 in colon carcinoma by Saeland, Eirikur, van Vliet, Sandra J, Bäckström, Malin, van den Berg, Venice C M, Geijtenbeek, Teunis B H, Meijer, Gerrit A, van Kooyk, Yvette

“…The epithelial mucin MUC1 is a high molecular weight membrane glycoprotein frequently overexpressed and aberrantly glycosylated in adenocarcinoma. Mucins…”
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Glycan modification of antigen alters its intracellular routing in dendritic cells, promoting priming of T cells by Streng-Ouwehand, Ingeborg, Ho, Nataschja I, Litjens, Manja, Kalay, Hakan, Boks, Martine Annemarie, Cornelissen, Lenneke A M, Kaur Singh, Satwinder, Saeland, Eirikur, Garcia-Vallejo, Juan J, Ossendorp, Ferry A, Unger, Wendy W J, van Kooyk, Yvette

“…Antigen uptake by dendritic cells and intracellular routing of antigens to specific compartments is regulated by C-type lectin receptors that recognize glycan…”
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Targeting glycan modified OVA to murine DC-SIGN transgenic dendritic cells enhances MHC class I and II presentation by Singh, Satwinder Kaur, Stephani, Johannes, Schaefer, Martin, Kalay, Hakan, García-Vallejo, Juan J., den Haan, Joke, Saeland, Eirikur, Sparwasser, Tim, van Kooyk, Yvette

“…Dendritic cells have gained much interest in the field of anti-cancer vaccine development because of their central function in immune regulation. One of the…”
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Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells by van Vliet, Sandra J., van Liempt, Ellis, Saeland, Eirikur, Aarnoudse, Corlien A., Appelmelk, Ben, Irimura, Tatsuro, Geijtenbeek, Teunis B. H., Blixt, Ola, Alvarez, Richard, van Die, Irma, van Kooyk, Yvette

“…Dendritic cells (DCs) are key to the maintenance of peripheral tolerance to self-antigens and the orchestration of an immune reaction to foreign antigens…”
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RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models by Cox, Freek, Saeland, Eirikur, Thoma, Anne, van den Hoogen, Ward, Tettero, Lisanne, Drijver, Joke, Vaneman, Cornelis, van Polanen, Yolinda, Ritschel, Tina, Bastian, Arangassery Rosemary, Callendret, Benoit, Zahn, Roland, van der Fits, Leslie

“…RSV is divided into two antigenic subtypes, RSV A and RSV B, which is largely based on the variation in the G protein, while the fusion protein F is more…”
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Adenovector 26 encoded prefusion conformation stabilized RSV-F protein induces long-lasting Th1-biased immunity in neonatal mice by van der Fits, Leslie, Bolder, Renske, Heemskerk-van der Meer, Marjolein, Drijver, Joke, van Polanen, Yolinda, Serroyen, Jan, Langedijk, Johannes P. M., Schuitemaker, Hanneke, Saeland, Eirikur, Zahn, Roland

“…While RSV is a major cause of respiratory morbidity in infants, vaccine development is hindered by the immaturity and Th2-bias of the infant immune system and…”
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The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription by Fabits, Markus, Gonçalves Magalhães, Vladimir, Chan, Baca, Girault, Virginie, Elbasani, Endrit, Rossetti, Elisa, Saeland, Eirikur, Messerle, Martin, Pichlmair, Andreas, Lisnić, Vanda Juranić, Brinkmann, Melanie M

“…The rapid activation of pattern recognition receptor (PRR)-mediated type I interferon (IFN) signaling is crucial for the host response to infection. In turn,…”
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Matrix-M Adjuvated Seasonal Virosomal Influenza Vaccine Induces Partial Protection in Mice and Ferrets against Avian H5 and H7 Challenge by Cox, Freek, Roos, Anna, Hafkemeijer, Nicole, Baart, Matthijs, Tolboom, Jeroen, Dekking, Liesbeth, Stittelaar, Koert, Goudsmit, Jaap, Radošević, Katarina, Saeland, Eirikur

“…There is a constant threat of zoonotic influenza viruses causing a pandemic outbreak in humans. It is virtually impossible to predict which virus strain will…”
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Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models by Saeland, Eirikur, van der Fits, Leslie, Bolder, Renske, Heemskerk-van der Meer, Marjolein, Drijver, Joke, van Polanen, Yolinda, Vaneman, Cornelis, Tettero, Lisanne, Cox, Freek, Serroyen, Jan, Jorgensen, Matthew J., Langedijk, Johannes P. M., Schuitemaker, Hanneke, Callendret, Benoit, Zahn, Roland C.

“…Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously shown that a…”
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Characterization of murine MGL1 and MGL2 C-type lectins: Distinct glycan specificities and tumor binding properties by Singh, Satwinder Kaur, Streng-Ouwehand, Ingeborg, Litjens, Manja, Weelij, Danny R., García-Vallejo, Juan Jesús, van Vliet, Sandra J., Saeland, Eirikur, van Kooyk, Yvette

“…Antigen presenting cells (APC) express a variety of pattern recognition receptors, including the C-type lectin receptors (CLR) that specifically recognize…”
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Glycosylation of fibroblast growth factor receptor 4 is a key regulator of fibroblast growth factor 19–mediated down‐regulation of cytochrome P450 7A1 by Triantis, Vassilis, Saeland, Eirikur, Bijl, Nora, Oude‐Elferink, Ronald P., Jansen, Peter L. M.

“…De novo bile acid synthesis in the liver needs to be tightly regulated in order to maintain optimal bile flow and prevent cholestasis. In the liver, fibroblast…”
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Central Role of Complement in Passive Protection by Human IgG1 and IgG2 Anti-pneumococcal Antibodies in Mice by Saeland, Eirikur, Vidarsson, Gestur, Leusen, Jeanette H. W, van Garderen, Evert, Nahm, Moon H, Vile-Weekhout, Henriette, Walraven, Vanessa, Stemerding, Annette M, Verbeek, J. Sjef, Rijkers, Ger T, Kuis, Wietse, Sanders, Elisabeth A. M, van de Winkel, Jan G. J

“…Streptococcus pneumoniae is an important cause of morbitity and mortality worldwide. Capsule-specific IgG1 and IgG2 Abs are induced upon vaccination with…”
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DC-SIGN specifically recognizes Streptococcus pneumoniae serotypes 3 and 14 by Koppel, Estella A., Saeland, Eirikur, de Cooker, Désirée J.M., van Kooyk, Yvette, Geijtenbeek, Teunis B.H.

“…The Gram-positive bacterium Streptococcus pneumoniae is the leading causative pathogen in community-acquired pneumonia. The ever-increasing frequency of…”
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Recognition of tumor glycans by antigen-presenting cells by Aarnoudse, Corlien A, Vallejo, Juan J García, Saeland, Eiríkur, van Kooyk, Yvette

“…C-type lectin receptors on antigen-presenting cells are potent antigen-uptake receptors with specificity for glycan structures. Glycosylation changes during…”
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Are the opsonophagocytic activities of antibodies in infant sera measured by different pneumococcal phagocytosis assays comparable? by Väkeväinen, M, Jansen, W, Saeland, E, Jonsdottir, I, Snippe, H, Verheul, A, Käyhty, H

“…Host protection against Streptococcus pneumoniae is mainly mediated by opsonin-dependent phagocytosis. Several techniques for measuring opsonophagocytic…”
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Immunogenicity and protective efficacy of adenoviral and subunit RSV vaccines based on stabilized prefusion F protein in pre-clinical models by Saeland, Eirikur, van der Fits, Leslie, Bolder, Renske, Heemskerk-van der Meer, Marjolein, Drijver, Joke, van Polanen, Yolinda, Vaneman, Cornelis, Tettero, Lisanne, Serroyen, Jan, Schuitemaker, Hanneke, Callendret, Benoit, Langedijk, Johannes P.M., Zahn, Roland C.

“…Respiratory Syncytial Virus (RSV) remains a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously…”
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Differential glycosylation of MUC1 and CEACAM5 between normal mucosa and tumour tissue of colon cancer patients by Saeland, Eirikur, Belo, Ana I., Mongera, Sandra, van Die, Irma, Meijer, Gerrit A., van Kooyk, Yvette

“…Altered glycosylation in epithelial cancers may play an important role in tumour progression, as it may affect tumour cell migration and antigen presentation…”
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