Search Results - "Saeki, Junjiro"

Oxidative stress is a triggering factor for LPS-induced Mrp2 internalization in the cryopreserved rat and human liver slices by Sekine, Shuichi, Yano, Kentaro, Saeki, Junjiro, Hashimoto, Nozomi, Fuwa, Toru, Horie, Toshiharu

“…Cholestasis develops during inflammation and is characterized as occurring under oxidative stress. We have described the internalization of multidrug…”
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LPS-induced dissociation of multidrug resistance-associated protein 2 (Mrp2) and radixin is associated with Mrp2 selective internalization in rats by Saeki, Junjiro, Sekine, Shuichi, Horie, Toshiharu

“…Multidrug resistance-associated protein 2 (Mrp2) is an ATP-dependent export pump that mediates the formation of bile-salt-independent bile flow. Disruption of…”
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Interaction of Mrp2 with radixin causes reversible canalicular Mrp2 localization induced by intracellular redox status by Sekine, Shuichi, Ito, Kousei, Saeki, Junjiro, Horie, Toshiharu

“…Oxidative stress is a feature of cholestatic syndrome and induces multidrug resistance-associated protein 2 (Mrp2) internalization from the canalicular…”
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Phase 1/2 Study Evaluating the Safety, Pharmacokinetics, and Preliminary Efficacy of Venetoclax in Japanese Subjects with Chronic Lymphocytic Leukemia by Hatake, Kiyohiko, Yamamoto, Kazuhito, Fukuhara, Noriko, Kusumoto, Shigeru, Izutsu, Koji, Choi, Ilseung, Nagai, Hirokazu, Honda, Hideyuki, Saeki, Junjiro, Roberts, Andrew W., Maciag, Paulo, Agarwal, Suresh, Salem, Ahmed Hamed, Freise, Kevin J., Kiriyama, Tsukasa, Tobinai, Kensei

“…Background: Venetoclax (VEN) is an orally bioavailable, small molecule inhibitor of BCL-2, an important anti-apoptosis regulator that is commonly overexpressed…”
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