Search Results - "Saed, Ghassan M."

The Impact of Myeloperoxidase and Activated Macrophages on Metaphase II Mouse Oocyte Quality by Shaeib, Faten, Khan, Sana N, Thakur, Mili, Kohan-Ghadr, Hamid-Reza, Drewlo, Sascha, Saed, Ghassan M, Pennathur, Subramaniam, Abu-Soud, Husam M

“…Myeloperoxidase (MPO), an abundant heme-containing enzyme present in neutrophils, monocytes, and macrophages, is produced in high levels during inflammation,…”
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Oxidative stress: a key regulator of leiomyoma cell survival by Fletcher, Nicole M., Ph.D, Abusamaan, Mohammed S., M.D, Memaj, Ira, B.S, Saed, Mohammed G., B.A, Al-Hendy, Ayman, M.D., Ph.D, Diamond, Michael P., M.D, Saed, Ghassan M., Ph.D

“…Objective To determine the effects of attenuating oxidative stress with the use of dichloroacetate (DCA) on the expression of key redox enzymes myeloperoxidase…”
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Potent antioxidative activity of lycopene: A potential role in scavenging hypochlorous acid by Pennathur, Subramaniam, Maitra, Dhiman, Byun, Jaeman, Sliskovic, Inga, Abdulhamid, Ibrahim, Saed, Ghassan M., Diamond, Michael P., Abu-Soud, Husam M.

“…Lycopene, a carotenoid found in tomatoes, is a proven antioxidant that may lower the risk of certain disorders including heart disease and cancer. Hypochlorous…”
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Diffused Intra-Oocyte Hydrogen Peroxide Activates Myeloperoxidase and Deteriorates Oocyte Quality by Khan, Sana N, Shaeib, Faten, Najafi, Tohid, Kavdia, Mahendra, Gonik, Bernard, Saed, Ghassan M, Goud, Pravin T, Abu-Soud, Husam M

“…Hydrogen peroxide (H2O2) is a relatively long-lived signaling molecule that plays an essential role in oocyte maturation, implantation, as well as early…”
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Adhesion phenotype manifests an altered metabolic profile favoring glycolysis by Fletcher, Nicole M., Ph.D, Awonuga, Awoniyi O., M.D, Abusamaan, Mohammed S., M.D, Saed, Mohammed G., B.A, Diamond, Michael P., M.D, Saed, Ghassan M., Ph.D

“…Objective To determine whether metabolic markers are differentially expressed in normal and adhesion fibroblasts with and without hypoxia exposure. Design…”
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A Single Nucleotide Polymorphism in Catalase Is Strongly Associated with Ovarian Cancer Survival by Belotte, Jimmy, Fletcher, Nicole M, Saed, Mohammed G, Abusamaan, Mohammed S, Dyson, Gregory, Diamond, Michael P, Saed, Ghassan M

“…Ovarian cancer is the deadliest of all gynecologic cancers. Recent evidence demonstrates an association between enzymatic activity altering single nucleotide…”
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Is there a link between talcum powder, oxidative stress, and ovarian cancer risk? by Saed, Ghassan M.

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Peroxynitrite affects the cumulus cell defense of metaphase II mouse oocytes leading to disruption of the spindle structure in vitro by Banerjee, Jashoman, M.D, Shaeib, Faten, M.D, Maitra, Dhiman, Ph.D, Saed, Ghassan M., Ph.D, Dai, Jing, Ph.D, Diamond, Michael P., M.D, Abu-Soud, Husam M., Ph.D

“…Objective To demonstrate the effects of peroxynitrite (ONOO− ) on metaphase II mouse oocyte spindle structure and chromosomal alignment in presence and absence…”
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Melatonin prevents myeloperoxidase heme destruction and the generation of free iron mediated by self-generated hypochlorous acid by Shaeib, Faten, Khan, Sana N, Ali, Iyad, Najafi, Tohid, Maitra, Dhiman, Abdulhamid, Ibrahim, Saed, Ghassan M, Pennathur, Subramaniam, Abu-Soud, Husam M

“…Myeloperoxidase (MPO) generated hypochlorous acid (HOCl) formed during catalysis is able to destroy the MPO heme moiety through a feedback mechanism, resulting…”
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Kinetic studies on the reaction between dicyanocobinamide and hypochlorous acid by Maitra, Dhiman, Ali, Iyad, Abdulridha, Rasha M, Shaeib, Faten, Khan, Sana N, Saed, Ghassan M, Pennathur, Subramaniam, Abu-Soud, Husam M

“…Hypochlorous acid (HOCl) is a potent oxidant generated by myeloperoxidase (MPO), which is an abundant enzyme used for defense against microbes. We examined the…”
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Shifting anaerobic to aerobic metabolism stimulates apoptosis through modulation of redox balance: potential intervention in the pathogenesis of postoperative adhesions by Fletcher, Nicole M., Ph.D, Awonuga, Awoniyi O., M.D, Neubauer, Bailey R., B.S, Abusamaan, Mohammed S., M.D, Saed, Mohammed G., B.A, Diamond, Michael P., M.D, Saed, Ghassan M., Ph.D

“…Objective To compare the effect of shifting anaerobic to aerobic metabolism on key regulators of oxidative stress, including extracellular superoxide dismutase…”
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Direct real-time measurement of intra-oocyte nitric oxide concentration in vivo by Goud, Pravin T, Goud, Anuradha P, Najafi, Tohid, Gonik, Bernard, Diamond, Michael P, Saed, Ghassan M, Zhang, Xueji, Abu-Soud, Husam M

“…Nitric oxide (NO) is reported to play significant a role in oocyte activation and maturation, implantation, and early embryonic development. Previously we have…”
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Modulation of redox signaling promotes apoptosis in epithelial ovarian cancer cells by Jiang, Zhongliang, Fletcher, Nicole M, Ali-Fehmi, Rouba, Diamond, Michael P, Abu-Soud, Husam M, Munkarah, Adnan R, Saed, Ghassan M

“…Abstract Objective Epithelial ovarian cancer (EOC) cells are known to be resistant to apoptosis through a mechanism that may involve alteration in their redox…”
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Hypochlorous acid-induced heme degradation from lactoperoxidase as a novel mechanism of free iron release and tissue injury in inflammatory diseases by Souza, Carlos Eduardo A, Maitra, Dhiman, Saed, Ghassan M, Diamond, Michael P, Moura, Arlindo A, Pennathur, Subramaniam, Abu-Soud, Husam M

“…Lactoperoxidase (LPO) is the major consumer of hydrogen peroxide (H(2)O(2)) in the airways through its ability to oxidize thiocyanate (SCN(-)) to produce…”
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Endometrial signaling pathways during ovarian stimulation for assisted reproduction technology by Detti, Laura, M.D, Uhlmann, Rebecca A., M.S, Fletcher, Nicole M., B.S, Diamond, Michael P., M.D, Saed, Ghassan M., Ph.D

“…Objective To determine the effects of different hormonal levels on endometrial biochemical development during ovulation induction for assisted reproduction…”
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Goserelin fosters bone elongation but does not prevent ovarian damage in cyclophosphamide-treated prepubertal mice by Detti, Laura, M.D, Uhlmann, Rebecca A., M.S, Zhang, Jie, M.D, Diamond, Michael P., M.D, Saed, Ghassan M., Ph.D, Fletcher, Nicole M., Ph.D, Lu, Meifen, B.S, Williams, Lucy J., E.L.D

“…Objective To evaluate whether administration of goserelin, a gonadotropin-releasing hormone (GnRH) agonist, could prevent acute or chronic ovarian…”
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Updates of the role of oxidative stress in the pathogenesis of ovarian cancer by Saed, Ghassan M, Diamond, Michael P, Fletcher, Nicole M

“…Abstract Clinical and epidemiological investigations have provided evidence supporting the role of reactive oxygen species (ROS) and reactive nitrogen species…”
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Dichloroacetate induces apoptosis of epithelial ovarian cancer cells through a mechanism involving modulation of oxidative stress by Saed, Ghassan M, Fletcher, Nicole M, Jiang, Zhong L, Abu-Soud, Husam M, Diamond, Michael P

“…Epithelial ovarian cancer (EOC) cells are under intrinsic oxidative stress, which alters metabolic activity and reduces apoptosis. Key oxidative stress…”
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Macrophages induce the adhesion phenotype in normal peritoneal fibroblasts by White, Jennell C., M.S, Jiang, Zhong L., M.D, Diamond, Michael P., M.D, Saed, Ghassan M., Ph.D

“…Objective To determine whether macrophages, exposed to hypoxia, stimulate primary cultures of fibroblasts to acquire the adhesion phenotype. The adhesion…”
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Endometrial morphology and modulation of hormone receptors during ovarian stimulation for assisted reproductive technology cycles by Detti, Laura, M.D, Saed, Ghassan M., Ph.D, Fletcher, Nicole M., Ph.D, Kruger, Michael L., M.A, Brossoit, Michelle, B.S, Diamond, Michael P., M.D

“…Objective To study the biochemical and morphologic implications of different hormonal levels on endometrial development during assisted reproductive technology…”
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