Endothelin-1, nitric oxide, serotonin and high blood pressure in male adolescents

Essential arterial hypertension (EAH) in adolescents represents a social burden. The endothelium is involved in the pathogenesis of EAH. Imbalance of key vasoactive factors - namely nitric oxide (NO) and endothelin-1 (ET-1) - is observed, and serotonin (5-HT) release is also impaired. The relationsh...

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Bibliographic Details
Published in:	Vascular health and risk management Vol. 14; pp. 213 - 223
Main Authors:	Aflyatumova, Gulfiia Nagimovna, Nigmatullina, Razina Ramazanovna, Sadykova, Dinara Ilgizarovna, Chibireva, Mariia Dmitrievna, Fugetto, Francesco, Serra, Raffaele
Format:	Journal Article
Language:	English
Published:	New Zealand Dove Medical Press Limited 01-01-2018 Dove Medical Press
Subjects:	Adolescent Age Factors Arterial Pressure Biological markers biomarkers Biomarkers - blood Blood pressure Case-Control Studies Endothelin Endothelin-1 Endothelin-1 - blood Endothelium Essential Hypertension - blood Essential Hypertension - diagnosis Essential Hypertension - epidemiology Essential Hypertension - physiopathology Humans Hypertension Male Nitric oxide Nitric Oxide - blood Nitrogen oxides Original Research pediatric arterial hypertension Phenols (Class of compounds) Prehypertension - blood Prehypertension - diagnosis Prehypertension - epidemiology Prehypertension - physiopathology Serotonin Serotonin - blood Sex Factors Tatarstan - epidemiology Youth nitric oxide serotonin biomarkers pediatric arterial hypertension pre-hypertension endothelin-1 endothelial dysfunction monoamines
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Summary:	Essential arterial hypertension (EAH) in adolescents represents a social burden. The endothelium is involved in the pathogenesis of EAH. Imbalance of key vasoactive factors - namely nitric oxide (NO) and endothelin-1 (ET-1) - is observed, and serotonin (5-HT) release is also impaired. The relationship between the factors and high blood pressure (BP) has been established mainly in preclinical studies and in the adult age. The aim of the present manuscript is to establish the association between plasma ET-1, serum NO and 5-HT, platelet 5-HT levels and BP in male adolescents, analyzing their concentrations in controls, prehypertensive and hypertensive children. Consequently, we want to evaluate ET-1, NO and 5-HT levels as preclinical biomarkers of EAH. Outpatient adolescents, examined at Children's Republican Clinical Hospital of the Ministry of Health of the Republic of Tatarstan, were recruited between 26th of May and 25th of September 2016. Predictor variables identified were plasma ET-1, serum NO and 5-HT levels and were evaluated in serum and platelets of case and control groups. Plasma ET-1 and serum 5-HT concentrations in prehypertensive and hypertensive children were higher than in controls, with hypertensive adolescents showing higher levels of both factors compared with prehypertensive adolescents. Platelet 5-HT levels were lower in prehypertensive and hypertensive children compared with controls, while serum NO levels were higher in prehypertensive children than in hypertensive children. Measurable ET-1, NO and 5-HT are related to BP in adolescents and may serve as diagnostic biomarkers of EAH. Furthermore, they could help to better define prehypertensive and hypertensive children.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1178-2048 1176-6344 1178-2048
DOI:	10.2147/VHRM.S170317