Search Results - "Sadruddin, Ahmad"

Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides by Desai, Tanvi J., Habulihaz, Bahanu, Cannon, Joe R., Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Johannes, Charles, Thean, Dawn, Brown, Chris J., Lane, David P., Partridge, Anthony W., Evers, Raymond, Sawyer, Tomi K., Hochman, Jerome

“…Purpose To develop a novel, target agnostic liposome click membrane permeability assay (LCMPA) using liposome encapsulating copper free click reagent dibenzo…”
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Macrocyclization of an all- d linear α-helical peptide imparts cellular permeability by Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.

“…Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Indeed, the vast diversity of…”
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Incorporation of Putative Helix-Breaking Amino Acids in the Design of Novel Stapled Peptides: Exploring Biophysical and Cellular Permeability Properties by Partridge, Anthony W, Kaan, Hung Yi Kristal, Juang, Yu-Chi, Sadruddin, Ahmad, Lim, Shuhui, Brown, Christopher J, Ng, Simon, Thean, Dawn, Ferrer, Fernando, Johannes, Charles, Yuen, Tsz Ying, Kannan, Srinivasaraghavan, Aronica, Pietro, Tan, Yaw Sing, Pradhan, Mohan R, Verma, Chandra S, Hochman, Jerome, Chen, Shiying, Wan, Hui, Ha, Sookhee, Sherborne, Brad, Lane, David P, Sawyer, Tomi K

“…Stapled α-helical peptides represent an emerging superclass of macrocyclic molecules with drug-like properties, including high-affinity target binding,…”
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Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling by Lim, Shuhui, Boyer, Nicolas, Boo, Nicole, Huang, Chunhui, Venkatachalam, Gireedhar, Angela Juang, Yu-Chi, Garrigou, Michael, Kaan, Hung Yi Kristal, Duggal, Ruchia, Peh, Khong Ming, Sadruddin, Ahmad, Gopal, Pooja, Yuen, Tsz Ying, Ng, Simon, Kannan, Srinivasaraghavan, Brown, Christopher J, Verma, Chandra S, Orth, Peter, Peier, Andrea, Ge, Lan, Yu, Xiang, Bhatt, Bhavana, Chen, Feifei, Wang, Erjia, Li, Nianyu Jason, Gonzales, Raymond J, Stoeck, Alexander, Henry, Brian, Sawyer, Tomi K, Lane, David P, Johannes, Charles W, Biswas, Kaustav, Partridge, Anthony W

“…Macrocyclic peptides have the potential to address intracellular protein-protein interactions (PPIs) of high value therapeutic targets that have proven largely…”
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Correction to: Liposome Click Membrane Permeability Assay for Identifying Permeable Peptides by Desai, Tanvi J., Habulihaz, Bahanu, Cannon, Joseph R., Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Johannes, Charles, Thean, Dawn, Brown, Chris J., Lane, David P., Partridge, Anthony W., Evers, Raymond, Sawyer, Tomi K., Hochman, Jerome

“…A Correction to this paper has been published: https://doi.org/10.1007/s11095-021-03033-9…”
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De-risking Drug Discovery of Intracellular Targeting Peptides: Screening Strategies to Eliminate False-Positive Hits by Ng, Simon, Juang, Yu-Chi, Chandramohan, Arun, Kaan, Hung Yi Kristal, Sadruddin, Ahmad, Yuen, Tsz Ying, Ferrer-Gago, Fernando J, Lee, Xue’Er Cheryl, Liew, Xi, Johannes, Charles W, Brown, Christopher J, Kannan, Srinivasaraghavan, Aronica, Pietro G, Berglund, Nils A, Verma, Chandra S, Liu, Lijuan, Stoeck, Alexander, Sawyer, Tomi K, Partridge, Anthony W, Lane, David P

“…Nonspecific promiscuous compounds can mislead researchers and waste significant resources. This phenomenon, though well-documented for small molecules, has not…”
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Discovery and Structure-Based Design of Macrocyclic Peptides Targeting STUB1 by Ng, Simon, Brueckner, Alexander C., Bahmanjah, Soheila, Deng, Qiaolin, Johnston, Jennifer M., Ge, Lan, Duggal, Ruchia, Habulihaz, Bahanu, Barlock, Benjamin, Ha, Sookhee, Sadruddin, Ahmad, Yeo, Constance, Strickland, Corey, Peier, Andrea, Henry, Brian, Sherer, Edward C., Partridge, Anthony W.

“…Recent evidence suggests that deletion of STUB1a pivotal negative regulator of interferon-γ sensingmay potentially clear malignant cells. However, current…”
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NanoClick: A High Throughput, Target-Agnostic Peptide Cell Permeability Assay by Peier, Andrea, Ge, Lan, Boyer, Nicolas, Frost, John, Duggal, Ruchia, Biswas, Kaustav, Edmondson, Scott, Hermes, Jeffrey D, Yan, Lin, Zimprich, Chad, Sadruddin, Ahmad, Kristal Kaan, Hung Yi, Chandramohan, Arun, Brown, Christopher J, Thean, Dawn, Lee, Xue Er, Yuen, Tsz Ying, Ferrer-Gago, Fernando J, Johannes, Charles W, Lane, David P, Sherborne, Brad, Corona, Cesear, Robers, Matthew B, Sawyer, Tomi K, Partridge, Anthony W

“…Macrocyclic peptides open new opportunities to target intracellular protein–protein interactions (PPIs) that are often considered nondruggable by traditional…”
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Macrocyclization of an all-d linear α-helical peptide imparts cellular permeability† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c9sc06383h by Kannan, Srinivasaraghavan, Aronica, Pietro G. A., Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J., Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J., Johannes, Charles W., Henry, Brian, Lane, David P., Sawyer, Tomi K., Verma, Chandra S., Partridge, Anthony W.

“…Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein–protein interactions (PPIs). Peptide-based molecules hold great…”
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Macrocyclization of an all- linear α-helical peptide imparts cellular permeability by Kannan, Srinivasaraghavan, Aronica, Pietro G. A, Ng, Simon, Gek Lian, Dawn Thean, Frosi, Yuri, Chee, Sharon, Shimin, Jiang, Yuen, Tsz Ying, Sadruddin, Ahmad, Kaan, Hung Yi Kristal, Chandramohan, Arun, Wong, Jin Huei, Tan, Yaw Sing, Chang, Zi Wei, Ferrer-Gago, Fernando J, Arumugam, Prakash, Han, Yi, Chen, Shiying, Rénia, Laurent, Brown, Christopher J, Johannes, Charles W, Henry, Brian, Lane, David P, Sawyer, Tomi K, Verma, Chandra S, Partridge, Anthony W

“…Peptide-based molecules hold great potential as targeted inhibitors of intracellular protein-protein interactions (PPIs). Indeed, the vast diversity of…”
Get full text