Search Results - "Sadovsky, Yoel"

The biology of extracellular vesicles: The known unknowns by Margolis, Leonid, Sadovsky, Yoel

“…For many years, double-layer phospholipid membrane vesicles, released by most cells, were not considered to be of biological significance. This stance has…”
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Microbial Vertical Transmission during Human Pregnancy by Arora, Nitin, Sadovsky, Yoel, Dermody, Terence S., Coyne, Carolyn B.

“…Congenital infections with pathogens such as Zika virus, Toxoplasma gondii, Listeria monocytogenes, Treponema pallidium, parvovirus, HIV, varicella zoster…”
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Isolation of exosomes from whole blood by integrating acoustics and microfluidics by Wu, Mengxi, Ouyang, Yingshi, Wang, Zeyu, Zhang, Rui, Huang, Po-Hsun, Chen, Chuyi, Li, Hui, Li, Peng, Quinn, David, Dao, Ming, Suresh, Subra, Sadovsky, Yoel, Huang, Tony Jun

“…Exosomes are nanoscale extracellular vesicles that play an important role in many biological processes, including intercellular communications, antigen…”
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Formation and size distribution of self-assembled vesicles by Huang, Changjin, Quinn, David, Sadovsky, Yoel, Suresh, Subra, Hsia, K. Jimmy

“…When detergents and phospholipid membranes are dispersed in aqueous solutions, they tend to self-assemble into vesicles of various shapes and sizes by virtue…”
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The function of miR-519d in cell migration, invasion, and proliferation suggests a role in early placentation by Xie, Lan, Sadovsky, Yoel

“…Abstract The processes of proliferation, migration, and invasion of extravillous trophoblasts are critical for placental implantation and early development,…”
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Unique microRNA Signals in Plasma Exosomes from Pregnancies Complicated by Preeclampsia by Li, Hui, Ouyang, Yingshi, Sadovsky, Elena, Parks, W. Tony, Chu, Tianjiao, Sadovsky, Yoel

“…Although preeclampsia is a common and serious complication of pregnancy, insight into its pathobiology and diagnosis is lacking. Circulating plasma exosomes,…”
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MicroRNAs in placental health and disease by Mouillet, Jean-François, PhD, Ouyang, Yingshi, PhD, Coyne, Carolyn B., PhD, Sadovsky, Yoel, MD

“…MicroRNAs (miRNAs) constitute a large family of small noncoding RNAs that are encoded by the genomes of most organisms. They regulate gene expression through…”
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Type III Interferons Produced by Human Placental Trophoblasts Confer Protection against Zika Virus Infection by Bayer, Avraham, Lennemann, Nicholas J., Ouyang, Yingshi, Bramley, John C., Morosky, Stefanie, Marques, Ernesto Torres De Azeved, Cherry, Sara, Sadovsky, Yoel, Coyne, Carolyn B.

“…During mammalian pregnancy, the placenta acts as a barrier between the maternal and fetal compartments. The recently observed association between Zika virus…”
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Pyroptosis is a critical inflammatory pathway in the placenta from early onset preeclampsia and in human trophoblasts exposed to hypoxia and endoplasmic reticulum stressors by Cheng, Shi-Bin, Nakashima, Akitoshi, Huber, Warren J., Davis, Sarah, Banerjee, Sayani, Huang, Zheping, Saito, Shigeru, Sadovsky, Yoel, Sharma, Surendra

“…Systemic manifestation of preeclampsia (PE) is associated with circulating factors, including inflammatory cytokines and damage-associated molecular patterns…”
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PLA2G6 guards placental trophoblasts against ferroptotic injury by Beharier, Ofer, Tyurin, Vladimir A., Goff, Julie P., Guerrero-Santoro, Jennifer, Kajiwara, Kazuhiro, Chu, Tianjiao, Tyurina, Yulia Y., St Croix, Claudette M., Wallace, Callen T., Parry, Samuel, Parks, W. Tony, Kagan, Valerian E., Sadovsky, Yoel

“…The recently identified ferroptotic cell death is characterized by excessive accumulation of hydroperoxy-arachidonoyl (C20:4)- or adrenoyl (C22:4)-…”
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Phospholipase iPLA2β averts ferroptosis by eliminating a redox lipid death signal by Sun, Wan-Yang, Tyurin, Vladimir A., Mikulska-Ruminska, Karolina, Shrivastava, Indira H., Anthonymuthu, Tamil S., Zhai, Yu-Jia, Pan, Ming-Hai, Gong, Hai-Biao, Lu, Dan-Hua, Sun, Jie, Duan, Wen-Jun, Korolev, Sergey, Abramov, Andrey Y., Angelova, Plamena R., Miller, Ian, Beharier, Ofer, Mao, Gao-Wei, Dar, Haider H., Kapralov, Alexandr A., Amoscato, Andrew A., Hastings, Teresa G., Greenamyre, Timothy J., Chu, Charleen T., Sadovsky, Yoel, Bahar, Ivet, Bayır, Hülya, Tyurina, Yulia Y., He, Rong-Rong, Kagan, Valerian E.

“…Ferroptosis, triggered by discoordination of iron, thiols and lipids, leads to the accumulation of 15-hydroperoxy (Hp)-arachidonoyl-phosphatidylethanolamine…”
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Human placental trophoblasts confer viral resistance to recipient cells by Delorme-Axford, Elizabeth, Donker, Rogier B., Mouillet, Jean-Francois, Chu, Tianjiao, Bayer, Avraham, Ouyang, Yingshi, Wang, Tianyi, Stolz, Donna B., Sarkar, Saumendra N., Morelli, Adrian E., Sadovsky, Yoel, Coyne, Carolyn B.

“…Placental trophoblasts form the interface between the fetal and maternal environments and serve to limit the maternal–fetal spread of viruses. Here we show…”
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Placental trophoblast syncytialization potentiates macropinocytosis via mTOR signaling to adapt to reduced amino acid supply by Shao, Xuan, Cao, Guangming, Chen, Dunjin, Liu, Juan, Yu, Bolan, Liu, Ming, Li, Yu-Xia, Cao, Bin, Sadovsky, Yoel, Wang, Yan-Ling

“…During pregnancy, the appropriate allocation of nutrients between the mother and the fetus is dominated by maternal–fetal interactions, which is primarily…”
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Organotypic models of type III interferon-mediated protection from Zika virus infections at the maternal–fetal interface by Corry, Jacqueline, Arora, Nitin, Good, Charles A., Sadovsky, Yoel, Coyne, Carolyn B.

“…Protecting the fetus from the hematogenous spread of viruses requires multifaceted layers of protection and relies heavily on trophoblasts, the fetal-derived…”
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Prevention of preterm birth: harnessing science to address the global epidemic by Rubens, Craig E, Sadovsky, Yoel, Muglia, Louis, Gravett, Michael G, Lackritz, Eve, Gravett, Courtney

“…Preterm birth is a leading cause of infant morbidity and mortality worldwide, but current interventions to prevent prematurity are largely ineffective. Preterm…”
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Placental response to maternal SARS-CoV-2 infection by Mourad, Mirella, Jacob, Taylor, Sadovsky, Elena, Bejerano, Shai, Simone, Glicella Salazar-De, Bagalkot, Tarique Rajasaheb, Zucker, Jason, Yin, Michael T., Chang, Jennifer Y., Liu, Lihong, Debelenko, Larisa, Shawber, Carrie J., Firestein, Morgan, Ouyang, Yingshi, Gyamfi-Bannerman, Cynthia, Penn, Anna, Sorkin, Alexander, Wapner, Ronald, Sadovsky, Yoel

“…The coronavirus disease 2019 (COVID-19) pandemic affected people at all ages. Whereas pregnant women seemed to have a worse course of disease than age-matched…”
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Comparison of syncytiotrophoblast generated from human embryonic stem cells and from term placentas by Yabe, Shinichiro, Alexenko, Andrei P., Amita, Mitsuyoshi, Yang, Ying, Schust, Danny J., Sadovsky, Yoel, Ezashi, Toshihiko, Roberts, R. Michael

“…Human embryonic stem cells (ESCs) readily commit to the trophoblast lineage after exposure to bone morphogenetic protein-4 (BMP-4) and two small compounds, an…”
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Vulnerability of primitive human placental trophoblast to Zika virus by Sheridan, Megan A., Yunusov, Dinar, Balaraman, Velmurugan, Alexenko, Andrei P., Yabe, Shinichiro, Verjovski-Almeida, Sergio, Schust, Danny J., Franz, Alexander W., Sadovsky, Yoel, Ezashi, Toshihiko, Roberts, R. Michael

“…Infection of pregnant women by Asian lineage strains of Zika virus (ZIKV) has been linked to brain abnormalities in their infants, yet it is uncertain when…”
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Placental origins of adverse pregnancy outcomes: potential molecular targets: an Executive Workshop Summary of the Eunice Kennedy Shriver National Institute of Child Health and Human Development by Ilekis, John V., PhD, Tsilou, Ekaterini, MD, Fisher, Susan, PhD, Abrahams, Vikki M., PhD, Soares, Michael J., PhD, Cross, James C., PhD, Zamudio, Stacy, PhD, Illsley, Nicholas P., DPhil, Myatt, Leslie, PhD, Colvis, Christine, PhD, Costantine, Maged M., MD, Haas, David M., MD, Sadovsky, Yoel, MD, Weiner, Carl, MD, Rytting, Erik, PhD, Bidwell, Gene, PhD

“…Although much progress is being made in understanding the molecular pathways in the placenta that are involved in the pathophysiology of pregnancy-related…”
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C19MC MicroRNAs Regulate the Migration of Human Trophoblasts by Xie, Lan, Mouillet, Jean-Francois, Chu, Tianjiao, Parks, W. Tony, Sadovsky, Elena, Knöfler, Martin, Sadovsky, Yoel

“…Early in pregnancy, trophoblast invasion into the decidua and inner myometrium is essential for establishment of proper implantation, maternal-fetal exchange,…”
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