Search Results - "Sadofsky, Moshe J."

PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain Required for Gene Silencing by Ivanov, Alexey V., Peng, Hongzhuang, Yurchenko, Vyacheslav, Yap, Kyoko L., Negorev, Dmitri G., Schultz, David C., Psulkowski, Elyse, Fredericks, William J., White, David E., Maul, Gerd G., Sadofsky, Moshe J., Zhou, Ming-Ming, Rauscher, Frank J.

“…Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind…”
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Medical Education From a Theory–Practice–Philosophy Perspective by Kirch, Susan A., Sadofsky, Moshe J.

“…Medical schooling, at least as structured in the United States and Canada, is commonly assembled intuitively or empirically to meet concrete goals. Despite a…”
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SUMO Modification of Human XRCC4 Regulates Its Localization and Function in DNA Double-Strand Break Repair by Yurchenko, Vyacheslav, Xue, Zhu, Sadofsky, Moshe J.

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Ku70 is stabilized by increased cellular SUMO by Yurchenko, Vyacheslav, Xue, Zhu, Gama, Vivian, Matsuyama, Shigemi, Sadofsky, Moshe J.

“…Ku70 is a protein that finds itself at the heart of several important cellular processes. It is essential to the non-homologous end joining pathway as a part…”
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Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice by Dudley, Darryll D, Sekiguchi, JoAnn, Zhu, Chengming, Sadofsky, Moshe J, Whitlow, Scott, DeVido, Jeffrey, Monroe, Robert J, Bassing, Craig H, Alt, Frederick W

“…RAG1 and RAG2 are the lymphocyte-specific components of the V(D)J recombinase. In vitro analyses of RAG function have relied on soluble, highly truncated…”
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WW-like module in the RAG1 N-terminal domain contributes to previously unidentified protein-protein interactions by Maitra, Radhashree, Sadofsky, Moshe J

“…More than one-third of the RAG1 protein can be truncated from the N-terminus with only subtle effects on the products of V(D)J recombination in vitro or in a…”
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The RAG proteins in V(D)J recombination: more than just a nuclease by Sadofsky, M J

“…V(D)J recombination is the process that generates the diversity among T cell receptors and is one of three mechanisms that contribute to the diversity of…”
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Recombination-activating gene proteins: more regulation, please by Sadofsky, Moshe J.

“…Developing B and T cells assemble gene segments in order to create the variable regions of immunoglobulin and T‐cell receptors required by our adaptive immune…”
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Initiation of V(D)J recombination in a cell-free system by van Gent, Dik C, Fraser McBlane, J, Ramsden, Dale A, Sadofsky, Moshe J, Hesse, Joanne E, Gellert, Martin

“…Cells performing V(D)J recombination make specific cuts in DNA at recombination signal sequences. Here, we show that nuclear extracts of pre-B cell lines carry…”
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A RAG1 and RAG2 Tetramer Complex Is Active in Cleavage in V(D)J Recombination by Bailin, Tu, Mo, Xianming, Sadofsky, Moshe J.

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A C-Terminal Region of RAG1 Contacts the Coding DNA during V(D)J Recombination by Mo, Xianming, Bailin, Tu, Sadofsky, Moshe J.

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RAG1 and RAG2 Cooperate in Specific Binding to the Recombination Signal Sequence in Vitro by Mo, Xianming, Bailin, Tu, Sadofsky, Moshe J.

“…An essential step in the development of the vertebrate immune system is the DNA level rearrangement of the antigen receptor genes. This process, termed “V(D)J…”
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A highly ordered structure in V(D)J recombination cleavage complexes is facilitated by HMG1 by Mo, X, Bailin, T, Noggle, S, Sadofsky, M J

“…Central to understanding the process of V(D)J recombination is appreciation of the protein-DNA complex which assembles on the recombination signal sequences…”
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Recombination-activating gene proteins: more regulation, please: V(D)J Recombination by SADOFSKY, Moshe J

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PHD Domain-Mediated E3 Ligase Activity Directs Intramolecular Sumoylation of an Adjacent Bromodomain which is Required for Gene Silencing by Ivanov, Alexey V., Peng, Hongzhuang, Yurchenko, Vyacheslav, Yap, Kyoko L., Negorev, Dmitri G., Schultz, David C., Psulkowski, Elyse, Fredericks, William J., White, David E., Maul, Gerd G., Sadofsky, Moshe J., Zhou, Ming-Ming, Rauscher, Frank J.

“…Tandem PHD and bromodomains are often found in chromatin-associated proteins and have been shown to cooperate in gene silencing. Each domain can bind…”
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Definition of a core region of RAG-2 that is functional in V(D)J recombination by Sadofsky, Moshe J., Hesse, Joanne E., Gellert, Martin

“…The products of the RAG-1 and RAG-2 genes cooperate to allow V(D)J recombination in lymphoid and nonlymphoid cells. As one step toward understanding the role…”
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Expression and V(D)J recombination activity of mutated RAG-1 proteins by Sadofsky, Moshe J., Hessw, Joanne E., McBlane, J.Fraser, Gellert, Martin

“…The products of the RAG-1 and RAG-2 genes ([1], [2]) are essential for the recombination of the DNA encoding the antigen receptors of the developing immune…”
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RAG-1 mutations that affect the target specificity of V(D)j recombination: a possible direct role of RAG-1 in site recognition by Sadofsky, M J, Hesse, J E, van Gent, D C, Gellert, M

“…The RAG-1 protein plays an essential role in V(D)j recombination, but its exact function has not yet been defined. Here we report that a particular mutation in…”
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Definition of a large region of RAG1 that is important for coimmunoprecipitation of RAG2 by McMahan, CJ, Sadofsky, MJ, Schatz, DG

“…Interaction between the RAG1 and RAG2 proteins is probably critical for V(D)J recombination. Using a coimmunoprecipitation assay, we define a large region of…”
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