Search Results - "Sadofsky, Laura R."

Modulation of transient receptor potential (TRP) channels by plant derived substances used in over-the-counter cough and cold remedies by Stinson, Rebecca J, Morice, Alyn H, Sadofsky, Laura R

“…Upper respiratory tract infections (URTIs) impact all age groups and have a significant economic and social burden on society, worldwide. Most URTIs are mild…”
Get full text

The pathogenesis of bleomycin-induced lung injury in animals and its applicability to human idiopathic pulmonary fibrosis by Williamson, James D., Sadofsky, Laura R., Hart, Simon P.

“…ABSTRACTIdiopathic pulmonary fibrosis (IPF) is a devastating disease of unknown etiology, for which there is no curative pharmacological therapy. Bleomycin, an…”
Get full text

Outdoor Atmospheric Microplastics within the Humber Region (United Kingdom): Quantification and Chemical Characterisation of Deposited Particles Present by Jenner, Lauren C., Sadofsky, Laura R., Danopoulos, Evangelos, Chapman, Emma, White, David, Jenkins, Rebecca L., Rotchell, Jeanette M.

“…Atmospheric microplastics (MPs) have been consistently captured within air samples on a global scale. Locations with high human activity are reported to have…”
Get full text

Ingredients of Vicks VapoRub inhibit rhinovirus-induced ATP release by Stinson, Rebecca J, Morice, Alyn H, Ahmad, Basir, Sadofsky, Laura R

“…BackgroundOver-the-counter therapies, such as Vicks VapoRub, are frequently used in the management of upper respiratory tract infection symptoms. Of these,…”
Get full text

Outdoor Microplastic Analysis Using Inlet Filters from an NOx Regulatory Air Quality Monitoring Device by Jenner, Lauren C., Kureshi, Rameez Raja, White, David, Chapman, Emma, Sadofsky, Laura R., Rotchell, Jeanette M.

“…Atmospheric microplastics (MPs) are a ubiquitous environmental contaminant of emerging concern. Sampling methods provide information relating to surface area…”
Get full text

Detection of microplastics in human lung tissue using μFTIR spectroscopy by Jenner, Lauren C., Rotchell, Jeanette M., Bennett, Robert T., Cowen, Michael, Tentzeris, Vasileios, Sadofsky, Laura R.

“…Airborne microplastics (MPs) have been sampled globally, and their concentration is known to increase in areas of high human population and activity,…”
Get full text

Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor by Morgan, Kevin, Sadofsky, Laura R, Crow, Christopher, Morice, Alyn H

“…TRPM8 (transient receptor potential M8) and TRPA1 (transient receptor potential A1) are cold-temperature-sensitive nociceptors expressed in sensory neurons but…”
Get full text

Rhinovirus-16 increases ATP release in A549 cells without concomitant increase in production by Atkinson, Samantha K., Morice, Alyn H., Sadofsky, Laura R.

“…Human rhinovirus (RV) is the most common cause of upper respiratory tract infection (URTI) and chronic airway disease exacerbation. Cough is present in 50–80%…”
Get full text

Lipid Laden Macrophages in Respiratory Disease by Sadofsky, Laura R, Hayman, Yvette A, Hart, Simon P, Morice, Alyn H

“…KCI Citation Count: 0…”
Get full text

TRPV1 polymorphisms influence capsaicin cough sensitivity in men by Sadofsky, Laura R, Cantero-Recasens, Gerard, Wright, Caroline, Valverde, Miguel A, Morice, Alyn H

Get full text

TRPA1 is activated by direct addition of cysteine residues to the N-hydroxysuccinyl esters of acrylic and cinnamic acids by Sadofsky, Laura R., Boa, Andrew N., Maher, Sarah A., Birrell, Mark A., Belvisi, Maria G., Morice, Alyn H.

“…The nociceptor TRPA1 is thought to be activated through covalent modification of specific cysteine residues on the N terminal of the channel. The precise…”
Get full text

Palmitoylation of human proteinase-activated receptor-2 differentially regulates receptor-triggered ERK1/2 activation, calcium signalling and endocytosis by Botham, Andrew, Guo, Xiaodan, Xiao, Yu Pei, Morice, Alyn H, Compton, Steven J, Sadofsky, Laura R

“…hPAR(2) (human proteinase-activated receptor-2) is a member of the novel family of proteolytically activated GPCRs (G-protein-coupled receptors) termed PARs…”
Get more information

The effects of exogenous lipid on THP-1 cells: an in vitro model of airway aspiration? by Hayman, Yvette A, Sadofsky, Laura R, Williamson, James D, Hart, Simon P, Morice, Alyn H

“…Chronic inflammatory diseases of the airways are associated with gastro-oesophageal reflux (GOR) and aspiration events. The observation of lipid-laden…”
Get full text

Microplastics in the surgical environment by Field, Daniel T., Green, Jordan L., Bennett, Robert, Jenner, Lauren C., Sadofsky, Laura.R., Chapman, Emma, Loubani, Mahmoud, Rotchell, Jeanette M.

“…[Display omitted] •Microplastics are present in surgical environments at 1,924 ± 3,105 m−2 day−1.•The abundance of microplastics were greatest during working…”
Get full text

Unique Responses are Observed in Transient Receptor Potential Ankyrin 1 and Vanilloid 1 (TRPA1 and TRPV1) Co-Expressing Cells by Sadofsky, Laura R, Sreekrishna, Koti T, Lin, Yakang, Schinaman, Renee, Gorka, Kate, Mantri, Yogita, Haught, John Christian, Huggins, Thomas G, Isfort, Robert J, Bascom, Charles C, Morice, Alyn H

“…Transient receptor potential (TRP) ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) receptors are implicated in modulation of cough and nociception. In vivo, TRPA1…”
Get full text

Inflammatory mediators modulate thrombin and cathepsin-G signaling in human bronchial fibroblasts by inducing expression of proteinase-activated receptor-4 by Ramachandran, Rithwik, Sadofsky, Laura R, Xiao, Yupei, Botham, Andrew, Cowen, Michael, Morice, Alyn H, Compton, Steven J

“…Human lung fibroblasts express proteinase-activated receptor-1 (PAR1), PAR2 and PAR3, but not PAR4. Because PAR2 has inflammatory effects on human primary…”
Get more information

Chronic cough-the limitation and advances in assessment techniques by Zhang, Mengru, Sykes, Dominic L, Brindle, Kayleigh, Sadofsky, Laura R, Morice, Alyn H

“…Accurate and consistent assessments of cough are essential to advance the understanding of the mechanisms of cough and individualised the management of…”
Get full text

ATP, an attractive target for the treatment of refractory chronic cough by Zhang, Mengru, Sykes, Dominic L., Sadofsky, Laura R., Morice, Alyn H.

“…Chronic cough is the most common complaint in respiratory clinics. Most of them have identifiable causes and some may respond to common disease-modifying…”
Get full text

Reduced expression of monocyte CD200R is associated with enhanced proinflammatory cytokine production in sarcoidosis by Fraser, Simon D., Sadofsky, Laura R., Kaye, Paul M., Hart, Simon P.

“…In sarcoidosis, the proinflammatory cytokines interferon gamma, tumour necrosis factor and interleukin-6 are released by monocyte-derived macrophages and…”
Get full text

Activation of mutated TRPA1 ion channel by resveratrol in human prostate cancer associated fibroblasts (CAF) by Vancauwenberghe, Eric, Noyer, Lucile, Derouiche, Sandra, Lemonnier, Loïc, Gosset, Pierre, Sadofsky, Laura R., Mariot, Pascal, Warnier, Marine, Bokhobza, Alexandre, Slomianny, Christian, Mauroy, Brigitte, Bonnal, Jean‐Louis, Dewailly, Etienne, Delcourt, Philippe, Allart, Laurent, Desruelles, Emilie, Prevarskaya, Natalia, Roudbaraki, Morad

“…Previous studies showed the effects of resveratrol (RES) on several cancer cells, including prostate cancer (PCa) cell apoptosis without taking into…”
Get full text