Search Results - "Sadler, Kirsten C"

Zebrafish: An Important Tool for Liver Disease Research by Goessling, Wolfram, Sadler, Kirsten C

“…As the incidence of hepatobiliary diseases increases, we must improve our understanding of the molecular, cellular, and physiological factors that contribute…”
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The shifting culture of the scientific workforce - a change for women and girls in science by Sadler, Kirsten C

“…Celebrating, educating and mobilizing the global community to achieve equality for women and girls in science is recognized worldwide each February 11 on the…”
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Epigenetic machinery is functionally conserved in cephalopods by Macchi, Filippo, Edsinger, Eric, Sadler, Kirsten C

“…Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet these mechanisms are not well studied in non-model organisms. Unique features of…”
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Chromatin states shaped by an epigenetic code confer regenerative potential to the mouse liver by Zhang, Chi, Macchi, Filippo, Magnani, Elena, Sadler, Kirsten C.

“…We hypothesized that the highly controlled pattern of gene expression that is essential for liver regeneration is encoded by an epigenetic code set in…”
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White adipose tissue development in zebrafish is regulated by both developmental time and fish size by Imrie, Dru, Sadler, Kirsten C.

“…Adipocytes are heterogeneous. Whether their differences are attributed to anatomical location or to different developmental origins is unknown. We investigated…”
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Conservation and divergence of methylation patterning in plants and animals by Feng, Suhua, Cokus, Shawn J, Zhang, Xiaoyu, Chen, Pao-Yang, Bostick, Magnolia, Goll, Mary G, Hetzel, Jonathan, Jain, Jayati, Strauss, Steven H, Halpern, Marnie E, Ukomadu, Chinweike, Sadler, Kirsten C, Pradhan, Sriharsa, Pellegrini, Matteo, Jacobsen, Steven E

“…Cytosine DNA methylation is a heritable epigenetic mark present in many eukaryotic organisms. Although DNA methylation likely has a conserved role in gene…”
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DNA Methylation, Nuclear Organization, and Cancer by Madakashira, Bhavani P, Sadler, Kirsten C

“…The dramatic re-organization of the cancer cell nucleus creates telltale morphological features critical for pathological staging of tumors. In addition, the…”
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High resolution annotation of zebrafish transcriptome using long-read sequencing by Nudelman, German, Frasca, Antonio, Kent, Brandon, Sadler, Kirsten C, Sealfon, Stuart C, Walsh, Martin J, Zaslavsky, Elena

“…With the emergence of zebrafish as an important model organism, a concerted effort has been made to study its transcriptome. This effort is limited, however,…”
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Hepatic steatosis in response to acute alcohol exposure in zebrafish requires sterol regulatory element binding protein activation by Passeri, Michael J., Cinaroglu, Ayca, Gao, Chuan, Sadler, Kirsten C.

“…Steatosis is the most common consequence of acute alcohol abuse and may predispose to more severe hepatic disease. Increased lipogenesis driven by the sterol…”
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Activating transcription factor 6 plays protective and pathological roles in steatosis due to endoplasmic reticulum stress in zebrafish by Cinaroglu, Ayca, Gao, Chuan, Imrie, Dru, Sadler, Kirsten C.

“…Many etiologies of fatty liver disease (FLD) are associated with the hyperactivation of one of the three pathways composing the unfolded protein response…”
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Activating transcription factor 6 is necessary and sufficient for alcoholic fatty liver disease in zebrafish by Howarth, Deanna L, Lindtner, Claudia, Vacaru, Ana M, Sachidanandam, Ravi, Tsedensodnom, Orkhontuya, Vasilkova, Taisa, Buettner, Christoph, Sadler, Kirsten C

“…Fatty liver disease (FLD) is characterized by lipid accumulation in hepatocytes and is accompanied by secretory pathway dysfunction, resulting in induction of…”
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Casting a wide net: use of diverse model organisms to advance toxicology by Hahn, Mark E, Sadler, Kirsten C

“…Toxicology - the study of how chemicals interact with biological systems - has clear relevance to human health and disease. Persistent exposure to natural and…”
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DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos by Jacob, Vinitha, Chernyavskaya, Yelena, Chen, Xintong, Tan, Poh Seng, Kent, Brandon, Hoshida, Yujin, Sadler, Kirsten C

“…UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated DNA during replication and is essential for maintaining DNA…”
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Loss of DNA methylation in zebrafish embryos activates retrotransposons to trigger antiviral signaling by Chernyavskaya, Yelena, Mudbhary, Raksha, Zhang, Chi, Tokarz, Debra, Jacob, Vinitha, Gopinath, Smita, Sun, Xiaochen, Wang, Shuang, Magnani, Elena, Madakashira, Bhavani P, Yoder, Jeffrey A, Hoshida, Yujin, Sadler, Kirsten C

“…Complex cytoplasmic nucleotide-sensing mechanisms can recognize foreign DNA based on a lack of methylation and initiate an immune response to clear the…”
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uhrf1 and dnmt1 Loss Induces an Immune Response in Zebrafish Livers Due to Viral Mimicry by Transposable Elements by Magnani, Elena, Macchi, Filippo, Madakashira, Bhavani P, Zhang, Chi, Alaydaroos, Fatima, Sadler, Kirsten C

“…Activation of transposable elements (TEs) can cause cellular damage. Cytoplasmic nucleic acid sensing pathways evolved to detect pathogens, but can also serve…”
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Inorganic arsenic causes fatty liver and interacts with ethanol to cause alcoholic liver disease in zebrafish by Bambino, Kathryn, Zhang, Chi, Austin, Christine, Amarasiriwardena, Chitra, Arora, Manish, Chu, Jaime, Sadler, Kirsten C

“…The rapid increase in fatty liver disease (FLD) incidence is attributed largely to genetic and lifestyle factors; however, environmental toxicants are a…”
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Sustained effects of developmental exposure to inorganic arsenic on hepatic gsto2 expression and mating success in zebrafish by Koomson, Abigail Ama, Delaney, Patrice, Khan, Nouf, Sadler, Kirsten C

“…The impacts of exposure to the pervasive environmental toxicant, inorganic arsenic (iAs), on human and fish health are well characterized and several lines of…”
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Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease by Tsedensodnom, Orkhontuya, Vacaru, Ana M, Howarth, Deanna L, Yin, Chunyue, Sadler, Kirsten C

“…Secretory pathway dysfunction and lipid accumulation (steatosis) are the two most common responses of hepatocytes to ethanol exposure and are major factors in…”
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Liver growth in the embryo and during liver regeneration in zebrafish requires the cell cycle regulator, uhrf1 by Sadler, Kirsten C, Krahn, Katherine N, Gaur, Naseem A, Ukomadu, Chinweike

“…In contrast to the deregulated hepatocellular division that is a feature of many hepatic diseases and malignancies, physiologic liver growth during embryonic…”
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RAF1 mutations in childhood-onset dilated cardiomyopathy by Dhandapany, Perundurai S, Razzaque, Md Abdur, Muthusami, Uthiralingam, Kunnoth, Sreejith, Edwards, Jonathan J, Mulero-Navarro, Sonia, Riess, Ilan, Pardo, Sherly, Sheng, Jipo, Rani, Deepa Selvi, Rani, Bindu, Govindaraj, Periyasamy, Flex, Elisabetta, Yokota, Tomohiro, Furutani, Michiko, Nishizawa, Tsutomu, Nakanishi, Toshio, Robbins, Jeffrey, Limongelli, Giuseppe, Hajjar, Roger J, Lebeche, Djamel, Bahl, Ajay, Khullar, Madhu, Rathinavel, Andiappan, Sadler, Kirsten C, Tartaglia, Marco, Matsuoka, Rumiko, Thangaraj, Kumarasamy, Gelb, Bruce D

“…Bruce Gelb and colleagues identify rare RAF1 mutations in individuals with childhood-onset dilated cardiomyopathy in three cohorts from South India, North…”
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