Phylogenetic relationships among the agent of bacillary angiomatosis, Bartonella bacilliformis, and other alpha-proteobacteria

Bacillary angiomatosis (BA) and chronic bartonellosis are bacterial infections of humans which result in an unusual vascular proliferative tissue response. In order to determine their phylogenetic relationships, we have determined greater than 95% of the 16S rRNA sequences for these two organisms by...

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Bibliographic Details
Published in:	Molecular microbiology Vol. 6; no. 13; p. 1801
Main Authors:	Relman, D A, Lepp, P W, Sadler, K N, Schmidt, T M
Format:	Journal Article
Language:	English
Published:	England 01-07-1992
Subjects:	Bacteria - classification Bacteria - genetics Bartonella - classification Bartonella - genetics Base Sequence Gram-Negative Bacteria - classification Gram-Negative Bacteria - genetics Molecular Sequence Data Nucleic Acid Conformation Phylogeny Rickettsiaceae - classification Rickettsiaceae - genetics RNA, Bacterial - chemistry RNA, Ribosomal, 16S - chemistry Sequence Homology, Nucleic Acid
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Summary:	Bacillary angiomatosis (BA) and chronic bartonellosis are bacterial infections of humans which result in an unusual vascular proliferative tissue response. In order to determine their phylogenetic relationships, we have determined greater than 95% of the 16S rRNA sequences for these two organisms by amplification directly from infected BA tissue and from a Bartonella bacilliformis lyophilized culture. The BA agent and B. bacilliformis are closely related alpha-proteobacteria (98.5%), although the BA agent is more closely related to Rochalimaea quintana (99.1%). Contrary to previous belief, the BA agent is distinct from, and less closely related to, the cat scratch bacillus (Afipia felis) (90.7%). We propose a novel secondary structure in a hypervariable region of the 16S rRNA which is useful for alignment of primary sequences and which may be useful for design of nucleic acid probes.
ISSN:	0950-382X
DOI:	10.1111/j.1365-2958.1992.tb01352.x