Search Results - "Sadik Shaik, Jafar"

Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke by Shaik, Jafar Sadik B, Ahmad, Muzamil, Li, Wenjin, Rose, Marie E, Foley, Lesley M, Hitchens, T Kevin, Graham, Steven H, Hwang, Sung Hee, Hammock, Bruce D, Poloyac, Samuel M

“…Soluble epoxide hydrolase (sEH) diminishes vasodilatory and neuroprotective effects of epoxyeicosatrienoic acids by hydrolyzing them to inactive dihydroxy…”
Get more information

20-Hydroxyeicosatetraenoic Acid Inhibition by HET0016 Offers Neuroprotection, Decreases Edema, and Increases Cortical Cerebral Blood Flow in a Pediatric Asphyxial Cardiac Arrest Model in Rats by Shaik, Jafar Sadik B, Poloyac, Samuel M, Kochanek, Patrick M, Alexander, Henry, Tudorascu, Dana L, Clark, Robert SB, Manole, Mioara D

“…Vasoconstrictive and vasodilatory eicosanoids generated after cardiac arrest (CA) may contribute to cerebral vasomotor disturbances and neurodegeneration. We…”
Get full text

A Phase 1 Study to Evaluate the Pharmacokinetics and Safety of Cabotegravir in Patients With Hepatic Impairment and Healthy Matched Controls by Shaik, Jafar Sadik B., Ford, Susan L., Lou, Yu, Zhang, Zhiping, Bakshi, Kalpana K., Tenorio, Allan R., Trezza, Christine, Spreen, William R., Patel, Parul

“…Cabotegravir is an investigational integrase inhibitor in development for the treatment and pre‐exposure prophylaxis of HIV‐1 infection. Liver disease is a…”
Get full text

Nipocalimab, an anti-FcRn monoclonal antibody, in participants with moderate to severe active rheumatoid arthritis and inadequate response or intolerance to anti-TNF therapy: results from the phase 2a IRIS-RA study by Taylor, Peter C, Schett, Georg, Huizinga, Tom WJ, Wang, Qingmin, Ibrahim, Fowzia, Zhou, Bei, Liva, Sophia G, Shaik, Jafar Sadik B, Xiong, Yuan, Leu, Jocelyn H, Panchakshari, Rohit A, Loza, Matthew J, Ma, Keying, Dhatt, Harman, Rojo Cella, Ricardo, Karyekar, Chetan S, Cuff, Carolyn A, Gao, Sheng, Fei, Kaiyin

“…ObjectivesTo investigate the efficacy, safety, pharmacokinetics and pharmacodynamics of nipocalimab in participants with moderate to severe active rheumatoid…”
Get full text

Concurrent determination of ezetimibe and its phase-I and II metabolites by HPLC with UV detection: Quantitative application to various in vitro metabolic stability studies and for qualitative estimation in bile by Basha, Shaik Jafar Sadik, Naveed, Shaik Abdul, Tiwari, Nirbhay Kumar, Shashikumar, Dhanya, Muzeeb, Syed, Kumar, Thammera Ranjith, Kumar, Nyavanandi Vijay, Rao, Nadipalli Prabhakar, Srinivas, Nanduri, Mullangi, Ramesh, Srinivas, Nuggehally R.

“…Simultaneous separation and quantification of ezetimibe (EZM) and its phase-I metabolite i.e., ezetimibe ketone (EZM-K) and phase-II metabolite i.e., ezetimibe…”
Get full text

Pharmacokinetics and tolerability of cabotegravir and rilpivirine long-acting intramuscular injections to the vastus lateralis (lateral thigh) muscles of healthy adult participants by Han, Kelong, Gevorkyan, Hakop, Sadik Shaik, Jafar, Crauwels, Herta, Leemereise, Claudia, Bontempo, Gilda, Win, Beta, Chounta, Vasiliki, Seal, Ciara, DeMoor, Rebecca, D'Amico, Ronald, Spreen, William R, Ford, Susan L

“…Cabotegravir + rilpivirine administered via intramuscular gluteal injections is the first complete long-acting (LA) regimen approved for maintaining HIV-1…”
Get full text

Rapid and simultaneous quantitation of prostanoids by UPLC–MS/MS in rat brain by Shaik, Jafar Sadik B., Miller, Tricia M., Graham, Steven H., Manole, Mioara D., Poloyac, Samuel M.

“…•Reports a UPLC–MS/MS method for detection of prostanoids in rat brain.•The processing conditions of this method were applied to eicosanoids…”
Get full text

Vascular characterization of mice with endothelial expression of cytochrome P450 4F2 by Cheng, Jennifer, Edin, Matthew L., Hoopes, Samantha L., Li, Hong, Bradbury, J. Alyce, Graves, Joan P., DeGraff, Laura M., Lih, Fred B., Garcia, Victor, Shaik, Jafar Sadik B., Tomer, Kenneth B., Flake, Gordon P., Falck, John R., Lee, Craig R., Poloyac, Samuel M., Schwartzman, Michal L., Zeldin, Darryl C.

“…ABSTRACT Cytochrome P450 (CYP) 4A and 4F enzymes metabolize arachidonic acid to 20‐hydroxyeico‐satetraenoic acid (20‐HETE). Although CYP4A‐derived 20‐HETE is…”
Get full text

Analysis of five HMG-CoA reductase inhibitors- atorvastatin, lovastatin, pravastatin, rosuvastatin and simvastatin: pharmacological, pharmacokinetic and analytical overview and development of a new method for use in pharmaceutical formulations analysis and in vitro metabolism studies by Pasha, Md. Khalid, Muzeeb, Syed, Basha, Shaik Jafar Sadik, Shashikumar, Dhanya, Mullangi, Ramesh, Srinivas, Nuggehally R.

“…A specific, accurate, precise and reproducible high‐performance liquid chromatographic (HPLC) method was developed and validated for the simultaneous…”
Get full text

Glucuronidation of DRF-6574, hydroxy metabolite of DRF-4367 (a novel COX-2 inhibitor) by pooled human liver, intestinal microsomes and recombinant human UDP-glucuronosyltransferases (UGT) : Role of UGT1A1,1A3 and 1A8 by MUZEEB, Syed, SHAIK JAFAR SADIK BASHA, SHASHIKUMAR, Dhanya, MULLANGI, Ramesh, SRINIVAS, Nuggehally R

“…DRF-4367 is a novel COX-2 inhibitor, which showed good efficacy in several animal models of inflammation. In a comparative in vitro metabolism in various liver…”
Get full text

Comparison between physiologically based pharmacokinetic and population pharmacokinetic modelling to select paediatric doses of gepotidacin in plague by Nguyen, Dung, Shaik, Jafar Sadik, Tai, Guoying, Tiffany, Courtney, Perry, Caroline, Dumont, Etienne, Gardiner, David, Barth, Aline, Singh, Rajendra, Hossain, Mohammad

“…Aims To develop physiologically based pharmacokinetic (PBPK) and population pharmacokinetic (PopPK) models to predict effective doses of gepotidacin in…”
Get full text

Pharmacokinetics and antiviral activity of cabotegravir and rilpivirine in cerebrospinal fluid following long-acting injectable administration in HIV-infected adults by Letendre, Scott L, Mills, Anthony, Hagins, Debbie, Swindells, Susan, Felizarta, Franco, Devente, Jerome, Bettacchi, Christopher, Lou, Yu, Ford, Susan, Sutton, Kenneth, Shaik, Jafar Sadik, Crauwels, Herta, D’Amico, Ronald, Patel, Parul

“…Abstract Background Long-acting (LA) formulations of cabotegravir, an HIV integrase inhibitor, and rilpivirine, an NNRTI, are in development as monthly or 2…”
Get full text

Multicompartmental pharmacokinetic evaluation of long‐acting cabotegravir in healthy adults for HIV preexposure prophylaxis by Shaik, Jafar Sadik, Weld, Ethel D., Edick, Stacey, Fuchs, Edward, Riddler, Sharon, Marzinke, Mark A., D'Amico, Ronald, Bakshi, Kalpana, Lou, Yu, Hendrix, Craig, Han, Kelong, Ford, Susan L., Margolis, David, Spreen, William, Patel, Parul

“…Aims Cabotegravir is an integrase strand transfer inhibitor in clinical development as long‐acting (LA) injectable HIV preexposure prophylaxis. Methods This…”
Get full text

Multiparametric magnetic resonance imaging to characterize cabotegravir long‐acting formulation depot kinetics in healthy adult volunteers by Jucker, Beat M., Fuchs, Edward J., Lee, Sarah, Damian, Valeriu, Galette, Paul, Janiczek, Robert, Macura, Katarzyna J., Jacobs, Michael A., Weld, Ethel D., Solaiyappan, Meiyappan, D'Amico, Ronald, Shaik, Jafar Sadik, Bakshi, Kalpana, Han, Kelong, Ford, Susan, Margolis, David, Spreen, William, Gupta, Manish K., Hendrix, Craig W., Patel, Parul

“…Aim Cabotegravir long‐acting (LA) intramuscular (IM) injection is being investigated for HIV preexposure prophylaxis due to its potent antiretroviral activity…”
Get full text

Activating Inducible T-cell Costimulator Yields Antitumor Activity Alone and in Combination with Anti-PD-1 Checkpoint Blockade by Yadavilli, Sapna, Waight, Jeremy D., Brett, Sara, Bi, Meixia, Zhang, Tianqian, Liu, Yao-Bin, Ellis, Catherine, Turner, David C., Hahn, Ashleigh, Shi, Hong, Seestaller-Wehr, Laura, Jing, Junping, Xie, Qing, Shaik, Jafar Sadik, Ji, Xiao, Gagnon, Robert, Fieles, William, Hook, Laura, Grant, Steven, Hopley, Stephanie, DeYoung, M. Phillip, Blackwell, Christina, Chisamore, Michael, Biddlecombe, Robert, Figueroa, David J., Hopson, Christopher B., Srinivasan, Roopa, Smothers, James, Maio, Michele, Rischin, Danny, Olive, Daniel, Paul, Elaine, Mayes, Patrick A., Hoos, Axel, Ballas, Marc

“…In recent years, there has been considerable interest in mAb-based induction of costimulatory receptor signaling as an approach to combat cancer. However,…”
Get full text

Pharmacokinetics of Cabotegravir in Subjects with Moderate Hepatic Impairment by Shaik, Jafar Sadik, Ford, Susan, Lou, Yu, Zhang, Zhiping, Bakshi, Kalpana, Tenorio, Allan, Trezza, Christine, Spreen, William, Patel, Parul

“…Abstract Background Cabotegravir (CAB) is an integrase inhibitor in phase 3 clinical trials for the treatment and prevention of HIV. CAB undergoes hepatic…”
Get full text

Evaluation of effects of CYP450 derived eicosanoids in cerebral ischemia by Bhasha Shaik, Jafar Sadik

“…Stroke and cardiac arrest (CA) both are characterized by severe fall in the cerebral blood flow (CBF) locally or globally at the onset of the event with…”
Get full text

Evaluation of effects of CYP450 derived eicosanoids in cerebral ischemia by Bhasha Shaik, Jafar Sadik

“…Stroke and cardiac arrest (CA) both are characterized by severe fall in the cerebral blood flow (CBF) locally or globally at the onset of the event with…”
Get full text