Search Results - "Sadik, H."

Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia by Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph

“…Tolerance to self-antigens prevents the elimination of cancer by the immune system 1 , 2 . We used synthetic chimeric antigen receptors (CARs) to overcome…”
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Chemotherapy-refractory diffuse large B-cell lymphoma and indolent B-cell malignancies can be effectively treated with autologous T cells expressing an anti-CD19 chimeric antigen receptor by Kochenderfer, James N, Dudley, Mark E, Kassim, Sadik H, Somerville, Robert P T, Carpenter, Robert O, Stetler-Stevenson, Maryalice, Yang, James C, Phan, Giao Q, Hughes, Marybeth S, Sherry, Richard M, Raffeld, Mark, Feldman, Steven, Lu, Lily, Li, Yong F, Ngo, Lien T, Goy, Andre, Feldman, Tatyana, Spaner, David E, Wang, Michael L, Chen, Clara C, Kranick, Sarah M, Nath, Avindra, Nathan, Debbie-Ann N, Morton, Kathleen E, Toomey, Mary Ann, Rosenberg, Steven A

“…T cells can be genetically modified to express an anti-CD19 chimeric antigen receptor (CAR). We assessed the safety and efficacy of administering autologous…”
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A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with response by Robbins, Paul F, Kassim, Sadik H, Tran, Thai L N, Crystal, Jessica S, Morgan, Richard A, Feldman, Steven A, Yang, James C, Dudley, Mark E, Wunderlich, John R, Sherry, Richard M, Kammula, Udai S, Hughes, Marybeth S, Restifo, Nicholas P, Raffeld, Mark, Lee, Chyi-Chia R, Li, Yong F, El-Gamil, Mona, Rosenberg, Steven A

“…Although adoptive cell therapy can be highly effective for the treatment of patients with melanoma, the application of this approach to the treatment of other…”
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Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanoma by Zhang, Ling, Morgan, Richard A, Beane, Joal D, Zheng, Zhili, Dudley, Mark E, Kassim, Sadik H, Nahvi, Azam V, Ngo, Lien T, Sherry, Richard M, Phan, Giao Q, Hughes, Marybeth S, Kammula, Udai S, Feldman, Steven A, Toomey, Mary Ann, Kerkar, Sid P, Restifo, Nicholas P, Yang, James C, Rosenberg, Steven A

“…Infusion of interleukin-12 (IL12) can mediate antitumor immunity in animal models, yet its systemic administration to patients with cancer results in minimal…”
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Donor-derived CD19-targeted T cells cause regression of malignancy persisting after allogeneic hematopoietic stem cell transplantation by Kochenderfer, James N., Dudley, Mark E., Carpenter, Robert O., Kassim, Sadik H., Rose, Jeremy J., Telford, William G., Hakim, Frances T., Halverson, David C., Fowler, Daniel H., Hardy, Nancy M., Mato, Anthony R., Hickstein, Dennis D., Gea-Banacloche, Juan C., Pavletic, Steven Z., Sportes, Claude, Maric, Irina, Feldman, Steven A., Hansen, Brenna G., Wilder, Jennifer S., Blacklock-Schuver, Bazetta, Jena, Bipulendu, Bishop, Michael R., Gress, Ronald E., Rosenberg, Steven A.

“…New treatments are needed for B-cell malignancies persisting after allogeneic hematopoietic stem cell transplantation (alloHSCT). We conducted a clinical trial…”
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Single-cell multiplexed cytokine profiling of CD19 CAR-T cells reveals a diverse landscape of polyfunctional antigen-specific response by Xue, Qiong, Bettini, Emily, Paczkowski, Patrick, Ng, Colin, Kaiser, Alaina, McConnell, Timothy, Kodrasi, Olja, Quigley, Máire F, Heath, James, Fan, Rong, Mackay, Sean, Dudley, Mark E, Kassim, Sadik H, Zhou, Jing

“…It remains challenging to characterize the functional attributes of chimeric antigen receptor (CAR)-engineered T cell product targeting CD19 related to potency…”
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The comparability tales: A phase-appropriate roadmap for CGT drug product development by Clément, Nathalie, Kassim, Sadik H., Leblanc, Daniel, Spink, Katy, Tomtishen, John

“…Cell and gene therapies (CGTs) have revolutionized patient outcomes and provided care options for previously untreatable conditions. The clinical and…”
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The Bespoke Gene Therapy Consortium: facilitating development of AAV gene therapies for rare diseases by Brooks, P. J., Miller, Timothy M., Revah, Frédéric, Suh, Junghae, Garrison, Bradley R., Starke, Lawrence C., MacLachlan, Timothy K., Neilan, Edward G., Raychaudhuri, Gopa, Kassim, Sadik H., Dehdashti, Jean, Rutter, Joni L.

“…A public–private partnership managed by the FNIH aims to address biological, manufacturing and regulatory challenges to the development of gene therapies for…”
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Adeno-associated virus serotype 8 gene therapy leads to significant lowering of plasma cholesterol levels in humanized mouse models of homozygous and heterozygous familial hypercholesterolemia by Kassim, Sadik H, Li, Hui, Bell, Peter, Somanathan, Suryanarayan, Lagor, William, Jacobs, Frank, Billheimer, Jeffrey, Wilson, James M, Rader, Daniel J

“…Familial hypercholesterolemia (FH) is a life-threatening genetic disease caused by mutations in the gene encoding low-density lipoprotein receptor (LDLR). As a…”
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Gene therapy in a humanized mouse model of familial hypercholesterolemia leads to marked regression of atherosclerosis by Kassim, Sadik H, Li, Hui, Vandenberghe, Luk H, Hinderer, Christian, Bell, Peter, Marchadier, Dawn, Wilson, Aisha, Cromley, Debra, Redon, Valeska, Yu, Hongwei, Wilson, James M, Rader, Daniel J

“…Familial hypercholesterolemia (FH) is an autosomal codominant disorder caused by mutations in the low-density lipoprotein receptor (LDLR) gene. Homozygous FH…”
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Characterization of age-related changes in natural killer cells during primary influenza infection in mice by Nogusa, Shoko, Ritz, Barry W., Kassim, Sadik H., Jennings, Stephen R., Gardner, Elizabeth M.

“…The current investigation examined the importance of natural killer (NK) cells during the innate immune response to primary influenza infection in young and…”
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The Therapeutic Effects of Bone Marrow-Derived Mesenchymal Stem Cells and Simvastatin in a Rat Model of Liver Fibrosis by Motawi, Tarek M. K., Atta, Hazem M., Sadik, Nermin A. H., Azzam, May

“…Liver fibrosis is the excessive accumulation of extracellular matrix (ECM) proteins including collagen that occurs in most types of chronic liver diseases…”
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Stereotactic cyst aspiration directly followed by Gamma Knife radiosurgery for large cystic brain metastases by Sadik, Zjiwar H. A., Hanssens, Patrick E. J., Verheul, Jeroen B., Ardon, Hilko, Lie, Suan Te, van der Pol, Bram, Beute, Guus N., Fleischeuer, Ruth E. M., Leenstra, Sieger

“…Background Gamma Knife radiosurgery (GKRS) has been proven to be a successful primary treatment for metastatic brain tumors (BM). BM can come in cystic lesions…”
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In Vivo Ablation of CD11c-Positive Dendritic Cells Increases Susceptibility to Herpes Simplex Virus Type 1 Infection and Diminishes NK and T-Cell Responses by Kassim, Sadik H, Rajasagi, Naveen K, Zhao, Xiangyi, Chervenak, Robert, Jennings, Stephen R

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Author Correction: Determinants of response and resistance to CD19 chimeric antigen receptor (CAR) T cell therapy of chronic lymphocytic leukemia by Fraietta, Joseph A., Lacey, Simon F., Orlando, Elena J., Pruteanu-Malinici, Iulian, Gohil, Mercy, Lundh, Stefan, Boesteanu, Alina C., Wang, Yan, O’Connor, Roddy S., Hwang, Wei-Ting, Pequignot, Edward, Ambrose, David E., Zhang, Changfeng, Wilcox, Nicholas, Bedoya, Felipe, Dorfmeier, Corin, Chen, Fang, Tian, Lifeng, Parakandi, Harit, Gupta, Minnal, Young, Regina M., Johnson, F. Brad, Kulikovskaya, Irina, Liu, Li, Xu, Jun, Kassim, Sadik H., Davis, Megan M., Levine, Bruce L., Frey, Noelle V., Siegel, Donald L., Huang, Alexander C., Wherry, E. John, Bitter, Hans, Brogdon, Jennifer L., Porter, David L., June, Carl H., Melenhorst, J. Joseph

“…A Correction to this paper has been published: https://doi.org/10.1038/s41591-021-01248-2…”
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Cytoprotective effects of DL-alpha-lipoic acid or squalene on cyclophosphamide-induced oxidative injury: An experimental study on rat myocardium, testicles and urinary bladder by Motawi, Tarek M.K., Sadik, Nermin A.H., Refaat, Ayat

“…The present study aimed to evaluate the role of DL-alpha-lipoic acid (LA) and squalene (SQ) on oxidative cardiac, testicular and urotoxic damage induced by…”
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CD4+ T Cells Are Required for the Priming of CD8+ T Cells following Infection with Herpes Simplex Virus Type 1 by Rajasagi, Naveen K, Kassim, Sadik H, Kollias, Christina M, Zhao, Xiangyi, Chervenak, Robert, Jennings, Stephen R

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From lipoproteins to chondrocytes: a brief summary of the European Medicines Agency's regulatory guidelines for advanced therapy medicinal products by Kassim, Sadik H, Somerville, Robert P T

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Dendritic Cells Are Required for Optimal Activation of Natural Killer Functions following Primary Infection with Herpes Simplex Virus Type 1 by KASSIM, Sadik H, RAJASAGI, Naveen K, RITZ, Barry W, PRUETT, Stephen B, GARDNER, Elizabeth M, CHERVENAK, Robert, JENNINGS, Stephen R

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The association of receptor of advanced glycated end products and inflammatory mediators contributes to endothelial dysfunction in a prospective study of acute kidney injury patients with sepsis by Sadik, Nermin A. H., Mohamed, Waleed A., Ahmed, Mohamed I.

“…The pathogenesis of acute kidney injury (AKI) occurring due to sepsis is incompletely understood. Endothelial activation, defined as up-regulation of adhesion…”
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