The correlation between severe complications and blood group types in COVID-19 patients; with possible role of T polyagglutination in promoting thrombotic tendencies

Introduction Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still posing detrimental effects on people. An association between contracting COVID-19 and the ABO blood group type has been determined. However, factors that determine the sev...

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Bibliographic Details
Published in:	AIMS medical science Vol. 10; no. 1; pp. 1 - 13
Main Authors:	Dobie, Gasim, Abutalib, Sarah, Sadifi, Wafa, Jahfali, Mada, Alghamdi, Bayan, Khormi, Asmaa, Alharbi, Taibah, Zaqan, Munyah, Baalous, Zahra M, Hakami, Abdulrahim R, Nahari, Mohammed H, Mobarki, Abdullah A, Saboor, Muhammad, Akhter, Mohammad S, Hamadi, Abdullah, Jackson, Denise E, Hamali, Hassan A
Format:	Journal Article
Language:	English
Published:	01-03-2023
Online Access:	Get full text
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Summary:	Introduction Coronavirus disease-19 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is still posing detrimental effects on people. An association between contracting COVID-19 and the ABO blood group type has been determined. However, factors that determine the severity of COVID-19 are not yet fully understood. Thus, the current study aimed to investigate whether the ABO blood group type has a role in the severity of complications due to COVID-19. Materials and methods Eighty-Six ICU-admitted COVID-19 patients and 80 matched-healthy controls were recruited in the study from Baish general hospital, Saudi Arabia. ABO blood grouping, complete blood count (CBC), CBC-derived inflammatory markers, coagulation profile, D-Dimer and anti-T antigen were reported. Results Our data showed that patients with blood groups O and B are more protective against severe complications from COVID-19, as compared to patients with blood groups A and AB. This could be partially attributed to the presence of anti-T in blood group A individuals, compared to non-blood group A. Conclusion The current study reports an association between the ABO blood group and the susceptibility to severe complications from COVID-19, with a possible role of anti-T in driving the mechanism of the thrombotic tendency, as it was also correlated with an elevation in D-dimer levels.
ISSN:	2375-1576
DOI:	10.3934/medsci.2023001