Search Results - "Sadick, Michael D"

Molecular Mimics of Insulin-like Growth Factor 1 (IGF-1) for Inhibiting IGF-1:  IGF-Binding Protein Interactions by Lowman, Henry B, Chen, Yvonne M, Skelton, Nicholas J, Mortensen, Deborah L, Tomlinson, Elizabeth E, Sadick, Michael D, Robinson, Iain C. A. F, Clark, Ross G

“…IGF-1 (insulin-like growth factor 1) is a 70-residue protein hormone which has both metabolic and mitogenic activities mediated through IGF-1 binding to cell…”
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Reevaluation of the roles of protein S and gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3 by Godowski, Paul J, Mark, Melanie R, Chen, Jian, Sadick, Michael D, Raab, Helga, Hammonds, R.Glenn

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Kinase receptor activation (KIRA): a rapid and accurate alternative to end-point bioassays by Sadick, Michael D, Intintoli, Anthony, Quarmby, Valerie, McCoy, April, Canova-Davis, Eleanor, Ling, Victor

“…We have developed a novel strategy for a rapid bioassay that is accurate, precise, sensitive, and high capacity. It is capable of quantifying ligand…”
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Binding Protein-3-Selective Insulin-Like Growth Factor I Variants: Engineering, Biodistributions, and Clearance by Dubaquié, Yves, Mortensen, Deborah L, Intintoli, Anthony, Hogue, Deborah A, Nakamura, Gerald, Rancatore, Patricia, Lester, Philip, Sadick, Michael D, Filvaroff, Ellen, Fielder, Paul J, Lowman, Henry B

“…Insulin-like growth factor I (IGF-I) is a potent anabolic peptide that mediates most of its pleiotropic effects through association with the IGF type I…”
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Tissue Disposition and Pharmacokinetics of Recombinant Human Nerve Growth Factor after Acute and Chronic Subcutaneous Administration in Monkeys by Nguyen, C B, Harris, L, Szönyi, E, Baughman, S A, Hale, V G, Dybdal, N O, Sadick, M D, Escandón, E

“…In this study, we have characterized the metabolism, tissue disposition, excretion routes, and plasma pharmacokinetics of recombinant human nerve growth factor…”
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Stability and Interactions of Recombinant Human Nerve Growth Factor in Different Biological Matrices: In Vitro and In Vivo Studies by Cindy B. Nguyen, Éva Szönyi, Michael D. Sadick, Timothy E. Hotaling, Jose-Luis Mendoza-Ramirez, Enrique Escandón

“…The purpose of this investigation was to characterize the stability, activity, and interactions of recombinant human nerve growth factor (rhNGF) in various…”
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Production of Interferon γ, Interleukin 2, Interleukin 4, and Interleukin 10 by CD4+Lymphocytes In vivo During Healing and Progressive Murine Leishmaniasis by Heinzel, Frederick P., Sadick, Michael D., Mutha, Sandesh S., Locksley, Richard M.

“…The expression of interleukin (IL) 2, IL-4, IL-10, and interferon γ (IFN-γ) by lymphocyte subsets was examined during infection of resistant C57BL/6 and…”
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Cure of murine leishmaniasis with anti-interleukin 4 monoclonal antibody: evidence for a T cell-dependent, interferon γ-independent mechanism by SADICK, M. D, HEINZEL, F. P, HOLADAY, B. J, PU, R. T, DAWKINS, R. S, LOCKSLEY, R. M

“…BALB/c mice infected with Leishmania major develop fatal, progressive disease, despite an immune response characterized by expansion of CD4+ T cells in the…”
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Reconstitution of Leishmania immunity in severe combined immunodeficient mice using Th1- and Th2-like cell lines by Holaday, BJ, Sadick, MD, Wang, ZE, Reiner, SL, Heinzel, FP, Parslow, TG, Locksley, RM

“…Leishmania major disseminates in genetically susceptible BALB/c mice to cause fatal disease. Progressive infection has been linked to the failure of…”
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Analysis of Neurotrophin/Receptor Interactions with a gD-Flag-Modified Quantitative Kinase Receptor Activation (gD.KIRA) Enzyme-Linked Immunosorbent Assay by Sadick, Michael D., Galloway, Amy, Shelton, David, Hale, Victoria, Weck, Suzanne, Anicetti, Vince, Wong, Wai Lee T.

“…A rapid, sensitive, and high-capacity assay has been developed to quantify ligand-induced receptor tyrosine kinase activation in terms of receptor…”
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Analysis of Heregulin-Induced ErbB2 Phosphorylation with a High-Throughput Kinase Receptor Activation Enzyme-Linked Immunosorbant Assay by Sadick, Michael D., Sliwkowski, Mark X., Nuijens, Andrew, Bald, Laura, Chiang, Nancy, Lofgren, Julie A., Wong, Wai Lee T.

“…A rapid, sensitive, and high-throughput assay has been developed to quantify ligand-induced receptor tyrosine kinase activation in terms of receptor…”
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Correlates of Leishmania-Specific Immunity in the Clinical Spectrum of Infection with Leishmania chagasi by Holaday, Bettie J., de Lima Pompeu, Margarida Maria, Evans, Thomas, de Melo Braga, Deborah Nunes, Texeira, Maria Jania, de Queiroz Sousa, Anastacio, Sadick, Michael D., Vasconcelos, Antonio Wilson, Abrams, John S., Pearson, Richard D., Locksley, Richard M.

“…Patients from across the spectrum of clinical manifestations of Leishmania chagasi infection were evaluated for in vitro correlates of immunity. Peripheral…”
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Leishmania major: analysis of lymphocyte and macrophage cellular phenotypes during infection of susceptible and resistant mice by Heinzel, F P, Sadick, M D, Locksley, R M

“…Genetically susceptible BALB/c and resistant C57BL/6 mice were infected with Leishmania major and the phenotypes of the responding cells in the draining lymph…”
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Leishmania tropica: differences in the antigenicity of promastigotes and amastigotes by Sadick, M D, Raff, H V

“…In vitro bioassays were used to compare T-cell responses induced by the intramacrophage amastigote stage and the sandfly-borne promastigote stage of Leishmania…”
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Development of cellular immunity in cutaneous leishmaniasis due to Leishmania tropica by Sadick, M.D, Locksley, R.M, Raff, H.V

“…A laboratory worker was inadvertently inoculated with infectious material while passaging amastigotes of Leishmania tropica. The subsequent development of a…”
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