Search Results - "Sadhwani, Heena"

Treatment of influenza and SARS-CoV-2 infections via mRNA-encoded Cas13a in rodents by Blanchard, Emmeline L., Vanover, Daryll, Bawage, Swapnil Subhash, Tiwari, Pooja Munnilal, Rotolo, Laura, Beyersdorf, Jared, Peck, Hannah E., Bruno, Nicholas C., Hincapie, Robert, Michel, Frank, Murray, Jackelyn, Sadhwani, Heena, Vanderheyden, Bob, Finn, M. G., Brinton, Margo A., Lafontaine, Eric R., Hogan, Robert J., Zurla, Chiara, Santangelo, Philip J.

“…Cas13a has been used to target RNA viruses in cell culture, but efficacy has not been demonstrated in animal models. In this study, we used messenger RNA…”
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Insertion position as well as the inserted TRS and gene sequences differentially affect the retention of foreign gene expression by simian hemorrhagic fever virus (SHFV) by Di, Han, Morantz, Esther K., Sadhwani, Heena, Madden, Joseph C., Brinton, Margo A.

“…Recombinant SHFV infectious cDNA clones expressing a foreign gene from an additional sg mRNA were constructed. Two 3′ genomic region sites, between ORF4′ and…”
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mRNA-encoded Cas13 can be used to treat dengue infections in mice by Basu, Mausumi, Zurla, Chiara, Auroni, Tabassum T., Vanover, Daryll, Chaves, Lorena C. S., Sadhwani, Heena, Pathak, Heather, Basu, Rahul, Beyersdorf, Jared P., Amuda, Oluwatomi O., Elsharkawy, Amany, Mosur, Varun, Arthur, Robert A., Claussen, Henry, Sasser, Loren E., Wroe, Jay A., Peck, Hannah E., Kumar, Mukesh, Brinton, Margo A., Santangelo, Philip J.

“…Dengue is a major global health threat, and there are no approved antiviral agents. Prior research using Cas13 only demonstrated dengue mitigation in vitro…”
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