The effect of black barberry hydroalcoholic extract on immune mediators in patients with active rheumatoid arthritis: A randomized, double–blind, controlled clinical trial

The effect of black barberry hydroalcoholic extract on immune mediators in patients with active rheumatoid arthritis: A randomized, double–blind, controlled clinical trial

Rheumatoid arthritis (RA) is an autoimmune disease associated with inflammation. In this trial, we aimed to investigate the Immunomodulatory effect of hydroalcoholic extract of black barberry on immune mediators in patients with active rheumatoid arthritis. In this randomized, double–blind, placebo‐...

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Bibliographic Details
Published in:Phytotherapy research Vol. 35; no. 2; pp. 1062 - 1068
Main Authors: Aryaeian, Naheed, Hadidi, Mahsa, Mahmoudi, Mahdi, Asgari, Marziyeh, Hezaveh, Zohreh Sajadi, Sadehi, Sara Khorshidi
Format: Journal Article
Language:English
Published: Chichester, UK John Wiley & Sons, Ltd 01-02-2021
Wiley Subscription Services, Inc
Subjects:
active rheumatoid arthritis
Acute Disease
Arthritis
Arthritis, Rheumatoid - drug therapy
Autoimmune diseases
Berberis - chemistry
black barberry
Clinical trials
Cytokines
Demographics
Diet
Dietary intake
Dietary supplements
Double-Blind Method
Double-blind studies
Female
Food intake
Humans
Immune response
Immune system
Immunomodulation
Inflammation
Lymphocytes T
Male
Maltodextrin
Middle Aged
Peripheral blood mononuclear cells
Physical activity
Placebos
Plant Extracts - chemistry
Rheumatoid arthritis
Statistical analysis
active rheumatoid arthritis
cytokines
immune response
inflammation
black barberry
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Summary:Rheumatoid arthritis (RA) is an autoimmune disease associated with inflammation. In this trial, we aimed to investigate the Immunomodulatory effect of hydroalcoholic extract of black barberry on immune mediators in patients with active rheumatoid arthritis. In this randomized, double–blind, placebo‐controlled clinical trial, 80 women with active RA were randomly assigned into two groups of two capsules, each containing 1,000 mg black barberry extract (n = 40) or maltodextrin placebo (n = 40) daily for 12 weeks. Demographic indices, physical activity, dietary intake, and disease activity were investigated using suitable questionnaires. Concentration of cytokines IL‐2, IL‐4, IL‐10, and IL‐17 in blood sample were measured using PBMC method. Statistical analysis was performed using SPSS (version 22). At baseline, there were no differences between the two groups in terms of demographic indices, physical activity, and dietary intake (p > .05). Black barberry supplementation reduced the severity of RA. It showed no significant effect on IL‐2 and IL‐4 cytokines (p > .05). IL‐17 levels decreased significantly after the intervention within the black barberry group, while IL‐10 had a significant increase in this group (p < .05). Barberry extract may reduce inflammatory and increase anti‐inflammatory cytokines in RA, and stimulates the immune response by increasing Th2 production.
Bibliography:Funding information
Iran University of Medical Sciences, Grant/Award Number: 5822
ObjectType-Article-2
SourceType-Scholarly Journals-1
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content type line 23
ISSN:0951-418X
1099-1573
DOI:10.1002/ptr.6874